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    Lsr lipolysis stimulated lipoprotein receptor [ Mus musculus (house mouse) ]

    Gene ID: 54135, updated on 21-Apr-2024

    Summary

    Official Symbol
    Lsrprovided by MGI
    Official Full Name
    lipolysis stimulated lipoprotein receptorprovided by MGI
    Primary source
    MGI:MGI:1927471
    See related
    Ensembl:ENSMUSG00000001247 AllianceGenome:MGI:1927471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ILDR3; Lisch7
    Summary
    Predicted to enable lipoprotein particle receptor activity and low-density lipoprotein particle binding activity. Involved in several processes, including establishment of blood-brain barrier; establishment of skin barrier; and tricellular tight junction assembly. Acts upstream of or within protein localization to tricellular tight junction. Located in plasma membrane and tricellular tight junction. Is expressed in several structures, including alimentary system; genitourinary system; limb; liver; and respiratory system. Orthologous to human LSR (lipolysis stimulated lipoprotein receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 232.1), small intestine adult (RPKM 213.3) and 13 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    7 B1; 7 19.27 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30657195..30672894, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30957770..30973469, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene hepcidin antimicrobial peptide Neighboring gene upstream transcription factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E10435 Neighboring gene family with sequence similarity 187, member B Neighboring gene olfactory receptor 1359 pseudogene Neighboring gene predicted gene, 42377 Neighboring gene STARR-positive B cell enhancer ABC_E3713

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipoprotein particle receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables low-density lipoprotein particle binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chylomicron IEA
    Inferred from Electronic Annotation
    more info
     
    part_of low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in tricellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in tricellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of very-low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lipolysis-stimulated lipoprotein receptor
    Names
    angulin-3
    lipolysis stimulated receptor
    liver-specific bHLH-Zip transcription factor
    liver-specific gene on mouse chromosome 7 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164184.1NP_001157656.1  lipolysis-stimulated lipoprotein receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001157656.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC149055, AK146807, BY028179
      Consensus CDS
      CCDS52186.1
      UniProtKB/Swiss-Prot
      Q99KG5
      Related
      ENSMUSP00000103751.4, ENSMUST00000108116.10
      Conserved Domains (2) summary
      pfam08648
      Location:451510
      DUF1777; Protein of unknown function (DUF1777)
      pfam12871
      Location:451512
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    2. NM_001164185.1NP_001157657.1  lipolysis-stimulated lipoprotein receptor isoform 3 precursor

      See identical proteins and their annotated locations for NP_001157657.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons in the central coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC149055, AK146807, AK167463, BY028179
      Consensus CDS
      CCDS52185.1
      UniProtKB/Swiss-Prot
      Q99KG5
      Related
      ENSMUSP00000096153.5, ENSMUST00000098553.11
      Conserved Domains (1) summary
      pfam08648
      Location:402461
      DUF1777; Protein of unknown function (DUF1777)
    3. NM_017405.2NP_059101.1  lipolysis-stimulated lipoprotein receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_059101.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC149055
      Consensus CDS
      CCDS21119.1
      UniProtKB/Swiss-Prot
      Q3TJE7, Q3UIQ9, Q61148, Q61149, Q6U816, Q99KG5
      Related
      ENSMUSP00000001279.8, ENSMUST00000001279.15
      Conserved Domains (2) summary
      pfam08648
      Location:470529
      DUF1777; Protein of unknown function (DUF1777)
      pfam12871
      Location:470531
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30657195..30672894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)