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    Cdkl2 cyclin dependent kinase like 2 [ Mus musculus (house mouse) ]

    Gene ID: 53886, updated on 2-May-2024

    Summary

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    Official Symbol
    Cdkl2provided by MGI
    Official Full Name
    cyclin dependent kinase like 2provided by MGI
    Primary source
    MGI:MGI:1858227
    See related
    Ensembl:ENSMUSG00000029403 AllianceGenome:MGI:1858227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kkm; KKIAMRE; 5330436L21Rik
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; genitourinary system; and parathyroid gland. Orthologous to human CDKL2 (cyclin dependent kinase like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 6.7), CNS E18 (RPKM 3.6) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 E2; 5 45.73 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92153933..92198479, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92006074..92043042, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13622 Neighboring gene ring finger and CHY zinc finger domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_13623 Neighboring gene THAP domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_13624 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene predicted gene, 46915 Neighboring gene STARR-positive B cell enhancer mm9_chr5:92471665-92471966 Neighboring gene predicted gene, 22728 Neighboring gene G3BP stress granule assembly factor 2 Neighboring gene predicted gene, 42111

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Involvement of cyclin-dependent kinase-like 2 in cognitive function required for contextual and spatial learning in mice. Gomi H, et al. Front Behav Neurosci, 2010. PMID 20428496, Free PMC Article
    2. Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus. Sassa T, et al. Cell Tissue Res, 2004 Feb. PMID 14605869
    3. Identification of variants and dual promoters of murine serine/threonine kinase KKIAMRE. Sassa T, et al. J Neurochem, 2000 May. PMID 10800923
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144031, MGC144032

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase-like 2
    Names
    cyclin dependent kinase like 2 (CDC2 related kinase)
    NP_001263244.1
    NP_058608.1
    NP_796244.2
    XP_011247839.1
    XP_011247840.1
    XP_011247841.1
    XP_017176476.1
    XP_017176477.1
    XP_017176479.1
    XP_036021189.1
    XP_036021190.1
    XP_036021191.1
    XP_036021192.1
    XP_036021193.1
    XP_036021194.1
    XP_036021195.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276315.1 → NP_001263244.1  cyclin-dependent kinase-like 2 isoform 2

      See identical proteins and their annotated locations for NP_001263244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon, which results in a frameshift in the 3' coding region, compared to variant 1. Variants 2 and 3 encode the same isoform (2, also known as gamma) which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB029066, AK030598, AK139820, BB616412, CD348339
      Consensus CDS
      CCDS19425.1
      UniProtKB/Swiss-Prot
      Q9QUK0
      Related
      ENSMUSP00000108768.2, ENSMUST00000113143.8
      Conserved Domains (2) summary
      smart00220
      Location:4 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    2. NM_016912.2 → NP_058608.1  cyclin-dependent kinase-like 2 isoform 1

      See identical proteins and their annotated locations for NP_058608.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1, also known as beta).
      Source sequence(s)
      AB029065, AB029066, AC165433, CD348339, CJ047658
      Consensus CDS
      CCDS19426.1
      UniProtKB/Swiss-Prot
      Q3UL60, Q3V3X7, Q9QUK0, Q9QYI1, Q9QYI2
      UniProtKB/TrEMBL
      Q149A0
      Related
      ENSMUSP00000084199.6, ENSMUST00000086978.12
      Conserved Domains (1) summary
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    3. NM_177270.4 → NP_796244.2  cyclin-dependent kinase-like 2 isoform 2

      See identical proteins and their annotated locations for NP_796244.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, which results in a frameshift in the 3' coding region, compared to variant 1. Variants 2 and 3 encode the same isoform (2, also known as gamma) which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB029066, AC165433, CD348339, CJ047658
      Consensus CDS
      CCDS19425.1
      UniProtKB/Swiss-Prot
      Q9QUK0
      Related
      ENSMUSP00000063617.5, ENSMUST00000069937.11
      Conserved Domains (2) summary
      smart00220
      Location:4 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      92153933..92198479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165300.1 → XP_036021193.1  cyclin-dependent kinase-like 2 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:2 → 224
      PKc_like; Protein Kinases, catalytic domain

    2. XM_036165297.1 → XP_036021190.1  cyclin-dependent kinase-like 2 isoform X2

      Conserved Domains (1) summary
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    3. XM_036165299.1 → XP_036021192.1  cyclin-dependent kinase-like 2 isoform X4

      Conserved Domains (1) summary
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    4. XM_017320987.3 → XP_017176476.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UL60, Q3V3X7, Q9QUK0, Q9QYI1, Q9QYI2
      UniProtKB/TrEMBL
      Q149A0
      Related
      ENSMUSP00000108765.2, ENSMUST00000113140.5
      Conserved Domains (1) summary
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    5. XM_036165298.1 → XP_036021191.1  cyclin-dependent kinase-like 2 isoform X4

      Conserved Domains (1) summary
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    6. XM_011249538.3 → XP_011247840.1  cyclin-dependent kinase-like 2 isoform X3

      Conserved Domains (1) summary
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    7. XM_011249537.4 → XP_011247839.1  cyclin-dependent kinase-like 2 isoform X1

      See identical proteins and their annotated locations for XP_011247839.1

      UniProtKB/Swiss-Prot
      Q3UL60, Q3V3X7, Q9QUK0, Q9QYI1, Q9QYI2
      UniProtKB/TrEMBL
      Q149A0
      Conserved Domains (1) summary
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    8. XM_017320988.2 → XP_017176477.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UL60, Q3V3X7, Q9QUK0, Q9QYI1, Q9QYI2
      UniProtKB/TrEMBL
      Q149A0
      Conserved Domains (1) summary
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    9. XM_036165301.1 → XP_036021194.1  cyclin-dependent kinase-like 2 isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:2 → 224
      PKc_like; Protein Kinases, catalytic domain

    10. XM_036165296.1 → XP_036021189.1  cyclin-dependent kinase-like 2 isoform X2

      Conserved Domains (1) summary
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    11. XM_011249539.3 → XP_011247841.1  cyclin-dependent kinase-like 2 isoform X5

      Conserved Domains (1) summary
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    12. XM_036165302.1 → XP_036021195.1  cyclin-dependent kinase-like 2 isoform X9

      Conserved Domains (1) summary
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

    13. XM_017320990.3 → XP_017176479.1  cyclin-dependent kinase-like 2 isoform X8

      Conserved Domains (1) summary
      cd07846
      Location:2 → 289
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QUK0.1 GenPept UniProtKB/Swiss-Prot:Q9QUK0

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