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    Septin9 septin 9 [ Mus musculus (house mouse) ]

    Gene ID: 53860, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Septin9provided by MGI
    Official Full Name
    septin 9provided by MGI
    Primary source
    MGI:MGI:1858222
    See related
    Ensembl:ENSMUSG00000059248 AllianceGenome:MGI:1858222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Msf; MSF1; Sept9; Sint1; PNUTL4
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cellular protein localization; cytoskeleton-dependent cytokinesis; and positive regulation of non-motile cilium assembly. Predicted to act upstream of or within cell division. Part of septin complex. Is expressed in several structures, including branchial arch; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in brachial plexus neuritis. Orthologous to human SEPTIN9 (septin 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 25.9), thymus adult (RPKM 24.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Septin9 in Genome Data Viewer
    Location:
    11 E2; 11 82.61 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117090487..117253151)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117199661..117362325)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9848 Neighboring gene predicted gene 11730 Neighboring gene SEC14-like lipid binding 1 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_31240 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117127061-117127170 Neighboring gene predicted gene, 39478 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117153788-117154073 Neighboring gene STARR-seq mESC enhancer starr_31245 Neighboring gene STARR-positive B cell enhancer ABC_E4019 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117181442-117181643 Neighboring gene STARR-positive B cell enhancer ABC_E8473 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117187354-117187555 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117195481-117195819 Neighboring gene VISTA enhancer mm1309 Neighboring gene predicted gene, 34065 Neighboring gene STARR-positive B cell enhancer ABC_E3041 Neighboring gene predicted gene, 34128 Neighboring gene predicted gene 11729

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Septin9 is involved in T-cell development and CD8+ T-cell homeostasis. Lassen LB, et al. Cell Tissue Res, 2013 Jun. PMID 23644740
    2. Alternative splicing, expression, and gene structure of the septin-like putative proto-oncogene Sint1. Sørensen AB, et al. Gene, 2002 Feb 20. PMID 12039034
    3. Sint1, a common integration site in SL3-3-induced T-cell lymphomas, harbors a putative proto-oncogene with homology to the septin gene family. Sørensen AB, et al. J Virol, 2000 Mar. PMID 10666245, Free PMC Article
    4. CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion. Farrugia AJ, et al. J Cell Biol, 2020 Sep 7. PMID 32798219, Free PMC Article
    5. Septins are critical regulators of osteoclastic bone resorption. Møller AMJ, et al. Sci Rep, 2018 Aug 29. PMID 30158637, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Septin 9 controls CCNB1 stabilization via APC/C[CDC20] during meiotic metaphase I/anaphase I transition in mouse oocytes.
      Title: Septin 9 controls CCNB1 stabilization via APC/C(CDC20) during meiotic metaphase I/anaphase I transition in mouse oocytes.
    2. CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion.
      Title: CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion.
    3. observations suggested that Sept9 contributed to alleviate liver fibrosis might partially through promoting activated HSCs apoptosis and this anti-fibrogenesis effect might be blocked by DNMT-3a mediated methylation of Sept9
      Title: Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis.
    4. The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8(+) central memory T-cells.
      Title: Septin9 is involved in T-cell development and CD8+ T-cell homeostasis.
    5. SEPT9 gene amplification and overexpression during mouse breast tumorigenesis
      Title: Septin 9 isoform expression, localization and epigenetic changes during human and mouse breast cancer progression.
    6. Data reveal the importance of Sept9 for septin filament formation and general cell stability.
      Title: Septin9 is involved in septin filament formation and cellular stability.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of septin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    septin-9
    Names
    MLL septin-like fusion
    SL3-3 integration site 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113486.1 → NP_001106958.1  septin-9 isoform a

      See identical proteins and their annotated locations for NP_001106958.1

      Status: VALIDATED

      Source sequence(s)
      AK122415, AK141312, AL645975, AW538697
      Consensus CDS
      CCDS48990.1
      UniProtKB/Swiss-Prot
      A2A6U2, A2A6U4, A2A6U6, Q3URP2, Q80TM7, Q80UG5, Q9QYX9
      Related
      ENSMUSP00000091435.5, ENSMUST00000093907.11
      Conserved Domains (2) summary
      cd01850
      Location:293 → 567
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:275 → 580
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    2. NM_001113487.1 → NP_001106959.1  septin-9 isoform b

      Status: VALIDATED

      Source sequence(s)
      AK122415, AW538697, BU148654
      Consensus CDS
      CCDS48991.1
      UniProtKB/Swiss-Prot
      Q80UG5
      Related
      ENSMUSP00000019038.9, ENSMUST00000019038.15
      Conserved Domains (2) summary
      cd01850
      Location:286 → 560
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:268 → 573
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    3. NM_001113488.1 → NP_001106960.1  septin-9 isoform c

      See identical proteins and their annotated locations for NP_001106960.1

      Status: VALIDATED

      Source sequence(s)
      AK031757, AK122415, AW538697, BY035742, BY772945
      Consensus CDS
      CCDS25684.1
      UniProtKB/TrEMBL
      Q3TDR9
      Related
      ENSMUSP00000101956.2, ENSMUST00000106349.2
      Conserved Domains (1) summary
      cd01850
      Location:44 → 318
      CDC_Septin; CDC/Septin GTPase family

    4. NM_017380.2 → NP_059076.1  septin-9 isoform c

      See identical proteins and their annotated locations for NP_059076.1

      Status: VALIDATED

      Source sequence(s)
      AJ250723, AK031757, AW538697, BU612221
      Consensus CDS
      CCDS25684.1
      UniProtKB/TrEMBL
      Q3TDR9
      Related
      ENSMUSP00000097767.2, ENSMUST00000100193.8
      Conserved Domains (1) summary
      cd01850
      Location:44 → 318
      CDC_Septin; CDC/Septin GTPase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      117090487..117253151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533744.3 → XP_006533807.1  septin-9 isoform X1

      UniProtKB/TrEMBL
      A2A6U3
      Related
      ENSMUSP00000101961.3, ENSMUST00000106354.9
      Conserved Domains (2) summary
      cd01850
      Location:275 → 549
      CDC_Septin; CDC/Septin GTPase family
      PHA03247
      Location:20 → 214
      PHA03247; large tegument protein UL36; Provisional

    2. XM_006533746.5 → XP_006533809.1  septin-9 isoform X2

      See identical proteins and their annotated locations for XP_006533809.1

      UniProtKB/TrEMBL
      Q3TDR9
      Conserved Domains (1) summary
      cd01850
      Location:44 → 318
      CDC_Septin; CDC/Septin GTPase family

    3. XM_030246153.2 → XP_030102013.1  septin-9 isoform X2

      UniProtKB/TrEMBL
      Q3TDR9
      Conserved Domains (1) summary
      cd01850
      Location:44 → 318
      CDC_Septin; CDC/Septin GTPase family

    4. XM_030246154.1 → XP_030102014.1  septin-9 isoform X2

      UniProtKB/TrEMBL
      Q3TDR9
      Conserved Domains (1) summary
      cd01850
      Location:44 → 318
      CDC_Septin; CDC/Septin GTPase family

    5. XM_006533745.5 → XP_006533808.2  septin-9 isoform X2

      See identical proteins and their annotated locations for XP_006533808.2

      UniProtKB/TrEMBL
      Q3TDR9
      Conserved Domains (1) summary
      cd01850
      Location:44 → 318
      CDC_Septin; CDC/Septin GTPase family

    6. XM_036156849.1 → XP_036012742.1  septin-9 isoform X2

      UniProtKB/TrEMBL
      Q3TDR9
      Conserved Domains (1) summary
      cd01850
      Location:44 → 318
      CDC_Septin; CDC/Septin GTPase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UG5.1 GenPept UniProtKB/Swiss-Prot:Q80UG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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