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    Prg3 proteoglycan 3 [ Mus musculus (house mouse) ]

    Gene ID: 53856, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Prg3provided by MGI
    Official Full Name
    proteoglycan 3provided by MGI
    Primary source
    MGI:MGI:1858200
    See related
    Ensembl:ENSMUSG00000027072 AllianceGenome:MGI:1858200
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MBP2; MBPH
    Summary
    Predicted to enable carbohydrate binding activity. Predicted to be involved in several processes, including granulocyte activation; histamine biosynthetic process; and regulation of gene expression. Is expressed in several structures, including gut; hemolymphoid system; liver; lung; and reproductive system. Orthologous to human PRG3 (proteoglycan 3, pro eosinophil major basic protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E18 (RPKM 1.5), liver E14 (RPKM 1.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 D; 2 49.45 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84818540..84826903)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84988196..84996559)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11144 Neighboring gene STARR-positive B cell enhancer ABC_E2629 Neighboring gene solute carrier family 43, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E7835 Neighboring gene STARR-positive B cell enhancer ABC_E7836 Neighboring gene STARR-positive B cell enhancer ABC_E11145 Neighboring gene predicted gene, 39868 Neighboring gene proteoglycan 2, bone marrow Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 3 Neighboring gene STARR-positive B cell enhancer ABC_E225 Neighboring gene structure specific recognition protein 1 Neighboring gene tankyrase 1 binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a new murine eosinophil major basic protein (mMBP) gene: cloning and characterization of mMBP-2. Macias MP, et al. J Leukoc Biol, 2000 Apr. PMID 10770291
    2. The transcription factor XBP1 is selectively required for eosinophil differentiation. Bettigole SE, et al. Nat Immunol, 2015 Aug. PMID 26147683, Free PMC Article
    3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
    4. Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Desai J, et al. Hum Mol Genet, 2006 Apr 15. PMID 16537572
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129482, MGC129483

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in basophil activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in histamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukotriene biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    proteoglycan 3
    Names
    eosinophil major basic protein 2
    major basic protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016914.2 → NP_058610.1  proteoglycan 3 precursor

      See identical proteins and their annotated locations for NP_058610.1

      Status: PROVISIONAL

      Source sequence(s)
      AL935159
      Consensus CDS
      CCDS16199.1
      UniProtKB/Swiss-Prot
      A2AW01, Q3SXA9, Q9JL95
      Related
      ENSMUSP00000028466.6, ENSMUST00000028466.12
      Conserved Domains (1) summary
      cd03598
      Location:108 → 222
      CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      84818540..84826903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162391.1 → XP_036018284.1  proteoglycan 3 isoform X1

      UniProtKB/Swiss-Prot
      A2AW01, Q3SXA9, Q9JL95
      Conserved Domains (1) summary
      cd03598
      Location:108 → 222
      CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JL95.1 GenPept UniProtKB/Swiss-Prot:Q9JL95

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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