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    Fut8 fucosyltransferase 8 [ Mus musculus (house mouse) ]

    Gene ID: 53618, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fut8provided by MGI
    Official Full Name
    fucosyltransferase 8provided by MGI
    Primary source
    MGI:MGI:1858901
    See related
    Ensembl:ENSMUSG00000021065 AllianceGenome:MGI:1858901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables alpha-(1->6)-fucosyltransferase activity. Acts upstream of or within several processes, including N-glycan fucosylation; N-glycan processing; and cell surface receptor signaling pathway. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Is expressed in telencephalon. Used to study pulmonary emphysema. Orthologous to human FUT8 (fucosyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 7.1), cerebellum adult (RPKM 6.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 C3; 12 35.46 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (77284878..77522770)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (77237430..77475998)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:78140672-78140781 Neighboring gene STARR-seq mESC enhancer starr_32552 Neighboring gene STARR-positive B cell enhancer ABC_E9859 Neighboring gene STARR-positive B cell enhancer mm9_chr12:78187234-78187534 Neighboring gene predicted gene, 35189 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:78232349-78232532 Neighboring gene STARR-positive B cell enhancer ABC_E1857 Neighboring gene STARR-positive B cell enhancer mm9_chr12:78271266-78271567 Neighboring gene predicted gene, 40446 Neighboring gene RIKEN cDNA 9530018F02 gene Neighboring gene STARR-positive B cell enhancer mm9_chr12:78399083-78399384 Neighboring gene STARR-seq mESC enhancer starr_32556 Neighboring gene STARR-seq mESC enhancer starr_32557 Neighboring gene STARR-seq mESC enhancer starr_32558 Neighboring gene protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene Neighboring gene predicted gene, 24775 Neighboring gene predicted gene, 25926 Neighboring gene Shwachman-Bodian-Diamond syndrome homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7150 Neighboring gene STARR-seq mESC enhancer starr_32559 Neighboring gene predicted gene, 35240 Neighboring gene STARR-seq mESC enhancer starr_32561 Neighboring gene histone deacetylase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32563 Neighboring gene predicted gene, 35440

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of FUT8 in renal tubules ameliorates ischemia-reperfusion injury-induced renal interstitial inflammation transition to fibrosis via the TLR3-NF-κB pathway. Li Z, et al. FASEB J, 2023 Aug. PMID 37432656
    2. Inhibition of core fucosylation limits progression of diabetic kidney disease. Fang M, et al. Biochem Biophys Res Commun, 2019 Dec 10. PMID 31623829
    3. Deficiency of α1,6-fucosyltransferase promotes neuroinflammation by increasing the sensitivity of glial cells to inflammatory mediators. Lu X, et al. Biochim Biophys Acta Gen Subj, 2019 Mar. PMID 30572004
    4. Core Fucosylation on T Cells, Required for Activation of T-Cell Receptor Signaling and Induction of Colitis in Mice, Is Increased in Patients With Inflammatory Bowel Disease. Fujii H, et al. Gastroenterology, 2016 Jun. PMID 26965517
    5. Loss of α1,6-Fucosyltransferase Decreases Hippocampal Long Term Potentiation: IMPLICATIONS FOR CORE FUCOSYLATION IN THE REGULATION OF AMPA RECEPTOR HETEROMERIZATION AND CELLULAR SIGNALING. Gu W, et al. J Biol Chem, 2015 Jul 10. PMID 25979332, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of FUT8 in renal tubules ameliorates ischemia-reperfusion injury-induced renal interstitial inflammation transition to fibrosis via the TLR3-NF-kappaB pathway.
      Title: Loss of FUT8 in renal tubules ameliorates ischemia-reperfusion injury-induced renal interstitial inflammation transition to fibrosis via the TLR3-NF-κB pathway.
    2. The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins.
      Title: The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins.
    3. Up-regulation of FUT8 inhibits TGF-beta1-induced activation of hepatic stellate cells during liver fibrogenesis.
      Title: Up-regulation of FUT8 inhibits TGF-β1-induced activation of hepatic stellate cells during liver fibrogenesis.
    4. FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation during Psoriasis Development.
      Title: FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation during Psoriasis Development.
    5. Caveolin-1 upregulates Fut8 expression by activating the Wnt/beta-catenin pathway to enhance HCC cell proliferative and invasive ability.
      Title: Caveolin-1 upregulates Fut8 expression by activating the Wnt/β-catenin pathway to enhance HCC cell proliferative and invasive ability.
    6. Structural basis of substrate recognition and catalysis by fucosyltransferase 8.
      Title: Structural basis of substrate recognition and catalysis by fucosyltransferase 8.
    7. Loss of core fucosylation in both ST6GAL1 and its substrate enhances glycoprotein sialylation in mice.
      Title: Loss of core fucosylation in both ST6GAL1 and its substrate enhances glycoprotein sialylation in mice.
    8. Core fucosylation negatively regulates the states of neuroinflammation by modulating the sensitivity of microglia and astrocytes to inflammatory mediators. The disorders of Fut8(-/-) mice are caused not only by neurons but also by glial cell dysfunction.
      Title: Deficiency of α1,6-fucosyltransferase promotes neuroinflammation by increasing the sensitivity of glial cells to inflammatory mediators.
    9. our study provides the first direct evidence for the involvement of Fut8 in liver regeneration.
      Title: Loss of α1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling.
    10. Loss of core fucosylation on AMPARs enhanced their heteromerization, which increase sensitivity for postsynaptic depolarization and persistently activate N-methyl-d-aspartate receptors as well as Ca(2+) influx and CaMKII and then impair LTP.
      Title: Loss of α1,6-Fucosyltransferase Decreases Hippocampal Long Term Potentiation: IMPLICATIONS FOR CORE FUCOSYLATION IN THE REGULATION OF AMPA RECEPTOR HETEROMERIZATION AND CELLULAR SIGNALING.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-(1->6)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->6)-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycoprotein 6-alpha-L-fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-L-fucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-glycan fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within N-glycan fucosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within N-glycan processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within receptor metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-(1,6)-fucosyltransferase
    Names
    GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
    GDP-fucose--glycoprotein fucosyltransferase
    alpha1-6FucT
    glycoprotein 6-alpha-L-fucosyltransferase
    NP_001239543.1
    NP_001239544.1
    NP_001239545.1
    NP_058589.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252614.1 → NP_001239543.1  alpha-(1,6)-fucosyltransferase isoform 1

      See identical proteins and their annotated locations for NP_001239543.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC110302, AC132342, AC159296
      Consensus CDS
      CCDS25999.1
      UniProtKB/Swiss-Prot
      Q543F5, Q921U1, Q9WTS2
      UniProtKB/TrEMBL
      Q3UYN7
      Related
      ENSMUSP00000136327.2, ENSMUST00000177595.9
      Conserved Domains (3) summary
      cd11300
      Location:174 → 499
      Fut8_like; Alpha 1-6-fucosyltransferase
      cd11792
      Location:506 → 560
      SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
      pfam12718
      Location:47 → 163
      Tropomyosin_1; Tropomyosin like

    2. NM_001252615.1 → NP_001239544.1  alpha-(1,6)-fucosyltransferase isoform 2

      See identical proteins and their annotated locations for NP_001239544.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK048520, CJ320809, EF591874
      UniProtKB/TrEMBL
      B2X2D7
      Related
      ENSMUST00000219299.2
      Conserved Domains (2) summary
      cd11300
      Location:11 → 336
      Fut8_like; Alpha 1-6-fucosyltransferase
      cd11792
      Location:343 → 397
      SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)

    3. NM_001252616.1 → NP_001239545.1  alpha-(1,6)-fucosyltransferase isoform 3

      See identical proteins and their annotated locations for NP_001239545.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK048520, CJ320809, EF591875
      UniProtKB/TrEMBL
      B2X2D8
      Related
      ENSMUST00000218851.2
      Conserved Domains (2) summary
      cd11300
      Location:10 → 310
      Fut8_like; Alpha 1-6-fucosyltransferase
      cd11792
      Location:317 → 371
      SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)

    4. NM_016893.5 → NP_058589.2  alpha-(1,6)-fucosyltransferase isoform 1

      See identical proteins and their annotated locations for NP_058589.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK048520, AK051811, BU702757, CJ320809
      Consensus CDS
      CCDS25999.1
      UniProtKB/Swiss-Prot
      Q543F5, Q921U1, Q9WTS2
      UniProtKB/TrEMBL
      Q3UYN7
      Related
      ENSMUSP00000130845.3, ENSMUST00000171770.10
      Conserved Domains (3) summary
      cd11300
      Location:174 → 499
      Fut8_like; Alpha 1-6-fucosyltransferase
      cd11792
      Location:506 → 560
      SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
      pfam12718
      Location:47 → 163
      Tropomyosin_1; Tropomyosin like

    RNA

    1. NR_045554.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' exon, which contains an upstream ORF with a strong Kozak signal, compared to variant 1. The transcript is sufficiently abundant to represent as a RefSeq record, but is predicted to be non-coding because the upstream ORF makes the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK048520, AK051811, AK134537, CJ070536

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      77284878..77522770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTS2.2 GenPept UniProtKB/Swiss-Prot:Q9WTS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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