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    Vti1a vesicle transport through interaction with t-SNAREs 1A [ Mus musculus (house mouse) ]

    Gene ID: 53611, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Vti1aprovided by MGI
    Official Full Name
    vesicle transport through interaction with t-SNAREs 1Aprovided by MGI
    Primary source
    MGI:MGI:1855699
    See related
    Ensembl:ENSMUSG00000024983 AllianceGenome:MGI:1855699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vti1; MVti1; MVti1a; Vti1-rp2; 1110014F16Rik; 1110018K19Rik; 4921537J05Rik
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; endosomal transport; and voluntary musculoskeletal movement. Predicted to act upstream of or within protein transport. Predicted to be located in several cellular components, including autophagosome; cytoplasmic vesicle; and neuronal cell body. Predicted to be part of SNARE complex. Predicted to be active in Golgi apparatus; cytoplasmic vesicle membrane; and endoplasmic reticulum membrane. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human VTI1A (vesicle transport through interaction with t-SNAREs 1A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 1.7), frontal lobe adult (RPKM 1.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 D2; 19 51.35 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (55304489..55615893)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (55316030..55627461)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31595 Neighboring gene acyl-CoA synthetase long-chain family member 5 Neighboring gene STARR-positive B cell enhancer ABC_E7673 Neighboring gene zinc finger, DHHC domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_46494 Neighboring gene STARR-seq mESC enhancer starr_46495 Neighboring gene STARR-seq mESC enhancer starr_46496 Neighboring gene STARR-seq mESC enhancer starr_46497 Neighboring gene STARR-seq mESC enhancer starr_46499 Neighboring gene STARR-positive B cell enhancer ABC_E2531 Neighboring gene STARR-positive B cell enhancer ABC_E2532 Neighboring gene RIKEN cDNA 4930552P12 gene Neighboring gene STARR-positive B cell enhancer ABC_E7674 Neighboring gene STARR-positive B cell enhancer ABC_E11041 Neighboring gene STARR-seq mESC enhancer starr_46505 Neighboring gene STARR-positive B cell enhancer ABC_E7675 Neighboring gene predicted gene, 41871 Neighboring gene predicted gene, 31734 Neighboring gene transcription factor 7 like 2, T cell specific, HMG box

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of hepatitis C virus (HCV) core protein transfection and host regulator PA28γ knockout in HCV pathogenesis: a network-based study. Tripathi LP, et al. J Proteome Res, 2012 Jul 6. PMID 22646850
    2. Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development. Bollmann C, et al. Neural Dev, 2022 Nov 22. PMID 36419086, Free PMC Article
    3. The SNARE protein vti1a functions in dense-core vesicle biogenesis. Walter AM, et al. EMBO J, 2014 Aug 1. PMID 24902738, Free PMC Article
    4. SNAREs in neurons--beyond synaptic vesicle exocytosis (Review). Wang Y, et al. Mol Membr Biol, 2006 Sep-Oct. PMID 17060155
    5. A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway. Xu Y, et al. J Biol Chem, 1998 Aug 21. PMID 9705316

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development.
      Title: Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development.
    2. Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex.
      Title: Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex.
    3. In adrenal chromaffin cells, vti1a localizes to a compartment near the trans-Golgi-network, but is absent from secretory granules.Vti1a is not required for final fusion of dense-core vesicles, but is needed for their generation.
      Title: The SNARE protein vti1a functions in dense-core vesicle biogenesis.
    4. VTI1A, a vesicular transport associated factor is a novel regulator of hepatitis C virus release but not replication.
      Title: Proteomic analysis of hepatitis C virus (HCV) core protein transfection and host regulator PA28γ knockout in HCV pathogenesis: a network-based study.
    5. Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development
      Title: Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102006

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle to endosome fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle fusion with Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in voluntary musculoskeletal movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vesicle transport through interaction with t-SNAREs homolog 1A
    Names
    vesicle transport through interaction with t-SNAREs 1 homolog
    vesicle transport v-SNARE protein Vti1-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293685.1 → NP_001280614.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform 1

      See identical proteins and their annotated locations for NP_001280614.1

      Status: VALIDATED

      Source sequence(s)
      AC133100, BB767664, BC089321
      Consensus CDS
      CCDS89416.1
      UniProtKB/TrEMBL
      Q5FWJ7
      Related
      ENSMUSP00000153629.2, ENSMUST00000223690.2
      Conserved Domains (2) summary
      cd15891
      Location:129 → 190
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 90
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    2. NM_001293686.1 → NP_001280615.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC133100, AK028646, AK148281, BB767664, BC089321
      UniProtKB/Swiss-Prot
      O89116
      UniProtKB/TrEMBL
      Q5FWJ7
      Conserved Domains (2) summary
      cd15891
      Location:122 → 183
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 89
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    3. NM_001360431.1 → NP_001347360.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC133100, AC166100, CO430297
      Conserved Domains (2) summary
      cd15891
      Location:129 → 190
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 90
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    4. NM_001360432.1 → NP_001347361.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC133100, AK135463
      Consensus CDS
      CCDS89417.1
      UniProtKB/TrEMBL
      A0A286YDF2
      Related
      ENSMUSP00000153392.2, ENSMUST00000225529.2
      Conserved Domains (2) summary
      cd15891
      Location:122 → 183
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 90
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    5. NM_016862.4 → NP_058558.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform 2

      See identical proteins and their annotated locations for NP_058558.1

      Status: VALIDATED

      Source sequence(s)
      AC133100, AK028646, BB767664, BC089321
      Consensus CDS
      CCDS29910.1
      UniProtKB/Swiss-Prot
      O89116, Q545P9
      Related
      ENSMUSP00000093644.3, ENSMUST00000095950.3
      Conserved Domains (2) summary
      cd15891
      Location:122 → 183
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 90
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      55304489..55615893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161635.1 → XP_036017528.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X12

      Conserved Domains (2) summary
      pfam05008
      Location:12 → 89
      V-SNARE; Vesicle transport v-SNARE protein N-terminus
      cl22856
      Location:122 → 142
      SNARE; SNARE motif

    2. XM_036161636.1 → XP_036017529.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X14

      Conserved Domains (2) summary
      pfam05008
      Location:12 → 89
      V-SNARE; Vesicle transport v-SNARE protein N-terminus
      cl22856
      Location:122 → 142
      SNARE; SNARE motif

    3. XM_017318251.3 → XP_017173740.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X3

      Conserved Domains (2) summary
      cd15891
      Location:129 → 190
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 90
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    4. XM_030250990.2 → XP_030106850.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X4

      Conserved Domains (2) summary
      cd15891
      Location:122 → 183
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 90
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    5. XM_006527192.5 → XP_006527255.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X9

      See identical proteins and their annotated locations for XP_006527255.1

      Conserved Domains (2) summary
      cd15891
      Location:129 → 190
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 90
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    6. XM_006527191.4 → XP_006527254.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X8

      See identical proteins and their annotated locations for XP_006527254.1

      Conserved Domains (2) summary
      cd15891
      Location:129 → 190
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 90
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    7. XM_006527188.4 → XP_006527251.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X7

      Conserved Domains (2) summary
      cd15891
      Location:129 → 190
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 90
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    8. XM_036161633.1 → XP_036017526.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X10

      Conserved Domains (2) summary
      cd15891
      Location:122 → 183
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 89
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    9. XM_036161630.1 → XP_036017523.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X5

      Conserved Domains (2) summary
      cd15891
      Location:129 → 190
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 89
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    10. XM_036161631.1 → XP_036017524.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X6

      Conserved Domains (2) summary
      cd15891
      Location:122 → 183
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 89
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    11. XM_006527184.5 → XP_006527247.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X1

      Conserved Domains (2) summary
      cd15891
      Location:129 → 190
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 90
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    12. XM_006527185.5 → XP_006527248.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X2

      Conserved Domains (2) summary
      cd15891
      Location:122 → 183
      SNARE_Vti1a; SNARE motif of Vti1b-like
      pfam05008
      Location:12 → 90
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    13. XM_036161634.1 → XP_036017527.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X11

      Conserved Domains (2) summary
      pfam05008
      Location:12 → 89
      V-SNARE; Vesicle transport v-SNARE protein N-terminus
      cl22856
      Location:129 → 149
      SNARE; SNARE motif

    14. XM_006527198.5 → XP_006527261.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X15

      Conserved Domains (1) summary
      pfam05008
      Location:12 → 90
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    15. XM_006527196.5 → XP_006527259.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X13

      Conserved Domains (2) summary
      pfam05008
      Location:12 → 90
      V-SNARE; Vesicle transport v-SNARE protein N-terminus
      cl22856
      Location:129 → 149
      SNARE; SNARE motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89116.1 GenPept UniProtKB/Swiss-Prot:O89116

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