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    Chst3 carbohydrate sulfotransferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 53374, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Chst3provided by MGI
    Official Full Name
    carbohydrate sulfotransferase 3provided by MGI
    Primary source
    MGI:MGI:1858224
    See related
    Ensembl:ENSMUSG00000057337 AllianceGenome:MGI:1858224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C6ST; GST-0; C6ST-1
    Summary
    Enables chondroitin 6-sulfotransferase activity and proteoglycan sulfotransferase activity. Acts upstream of or within T cell homeostasis and chondroitin sulfate biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in trans-Golgi network. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and respiratory system. Used to study schizophrenia. Human ortholog(s) of this gene implicated in osteochondrodysplasia and spondyloepiphyseal dysplasia with congenital joint dislocations. Orthologous to human CHST3 (carbohydrate sulfotransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 18.8), mammary gland adult (RPKM 4.5) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B4; 10 29.7 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (60017349..60057936, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (60181527..60222114, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 Neighboring gene microRNA 6906 Neighboring gene STARR-positive B cell enhancer ABC_E5138 Neighboring gene predicted gene, 51802 Neighboring gene STARR-seq mESC enhancer starr_26799 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59631170-59631353 Neighboring gene STARR-positive B cell enhancer ABC_E10611 Neighboring gene STARR-positive B cell enhancer mm9_chr10:59652431-59652731 Neighboring gene STARR-positive B cell enhancer ABC_E11440 Neighboring gene STARR-positive B cell enhancer mm9_chr10:59692925-59693225 Neighboring gene headcase homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2325 Neighboring gene STARR-seq mESC enhancer starr_26804 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59740166-59740349 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59747447-59747650 Neighboring gene prosaposin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNA interference targeting carbohydrate sulfotransferase 3 diminishes macrophage accumulation, inhibits MMP-9 expression and promotes lung recovery in murine pulmonary emphysema. Kai Y, et al. Respir Res, 2015 Dec 9. PMID 26646821, Free PMC Article
    2. Involvement of chondroitin 6-sulfation in temporal lobe epilepsy. Yutsudo N, et al. Exp Neurol, 2015 Dec. PMID 26231575
    3. 6-Sulphated chondroitins have a positive influence on axonal regeneration. Lin R, et al. PLoS One, 2011. PMID 21747937, Free PMC Article
    4. Persistent cortical plasticity by upregulation of chondroitin 6-sulfation. Miyata S, et al. Nat Neurosci, 2012 Jan 15. PMID 22246436
    5. Functional analysis of the chondroitin 6-sulfotransferase gene in relation to lymphocyte subpopulations, brain development, and oversulfated chondroitin sulfates. Uchimura K, et al. J Biol Chem, 2002 Jan 11. PMID 11696535

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CHST3 siRNA diminishes accumulation of excessive macrophages and the mediators, leading to accelerate the functional recovery from airway damage by repair of the elastin network associated with pulmonary emphysema
      Title: RNA interference targeting carbohydrate sulfotransferase 3 diminishes macrophage accumulation, inhibits MMP-9 expression and promotes lung recovery in murine pulmonary emphysema.
    2. These results suggested that chondroitin 6-sulfation is relevant to epilepsy most probably because of dysregulated perineuronal nets formation and parvalbumin cell maturation.
      Title: Involvement of chondroitin 6-sulfation in temporal lobe epilepsy.
    3. neither KSGal6ST nor C6ST-1 is required for Siglec-F ligand synthesis in leukocytes or lung tissue
      Title: Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.
    4. the expression of chondroitin 6-sulfotransferase correlated negatively with mast cell maturation.
      Title: Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chondroitin 6-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chondroitin 6-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chondroitin 6-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables keratan sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteoglycan sulfotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables proteoglycan sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within T cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chondroitin sulfate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chondroitin sulfate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within chondroitin sulfate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chondroitin sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfur compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 3
    Names
    carbohydrate (chondroitin 6/keratan) sulfotransferase 3
    chondroitin 6-O-sulfotransferase 1
    chondroitin 6-sulfotransferase
    galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
    NP_001393954.1
    NP_058083.3
    XP_011241812.1
    XP_011241815.1
    XP_017169519.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001407025.1 → NP_001393954.1  carbohydrate sulfotransferase 3

      Status: VALIDATED

      Source sequence(s)
      AC155640
      UniProtKB/Swiss-Prot
      O88199, Q794I5
      Related
      ENSMUSP00000065010.7, ENSMUST00000068690.7

    2. NM_016803.4 → NP_058083.3  carbohydrate sulfotransferase 3

      Status: VALIDATED

      Source sequence(s)
      AC155640
      Consensus CDS
      CCDS23871.2
      UniProtKB/Swiss-Prot
      O88199, Q794I5
      Related
      ENSMUSP00000131532.2, ENSMUST00000167915.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      60017349..60057936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314030.2 → XP_017169519.1  carbohydrate sulfotransferase 3 isoform X1

      UniProtKB/TrEMBL
      G5E8X5
      Conserved Domains (1) summary
      pfam00685
      Location:265 → 451
      Sulfotransfer_1; Sulfotransferase domain

    2. XM_011243510.4 → XP_011241812.1  carbohydrate sulfotransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_011241812.1

      UniProtKB/TrEMBL
      G5E8X5
      Conserved Domains (1) summary
      pfam00685
      Location:265 → 451
      Sulfotransfer_1; Sulfotransferase domain

    3. XM_011243513.4 → XP_011241815.1  carbohydrate sulfotransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_011241815.1

      UniProtKB/TrEMBL
      G5E8X5
      Conserved Domains (1) summary
      pfam00685
      Location:265 → 451
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88199.1 GenPept UniProtKB/Swiss-Prot:O88199

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