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    Tomm40 translocase of outer mitochondrial membrane 40 [ Mus musculus (house mouse) ]

    Gene ID: 53333, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Tomm40provided by MGI
    Official Full Name
    translocase of outer mitochondrial membrane 40provided by MGI
    Primary source
    MGI:MGI:1858259
    See related
    Ensembl:ENSMUSG00000002984 AllianceGenome:MGI:1858259
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mom35; Tom40
    Summary
    Predicted to enable cation channel activity; preprotein binding activity; and protein transmembrane transporter activity. Predicted to be involved in positive regulation of apoptotic process; protein import into mitochondrial matrix; and protein insertion into mitochondrial membrane. Predicted to act upstream of or within ion transport and protein transport. Located in mitochondrial outer membrane. Is integral component of mitochondrial membrane. Is expressed in lung mesenchyme. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human TOMM40 (translocase of outer mitochondrial membrane 40). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 63.6), ovary adult (RPKM 47.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A3; 7 9.94 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19435238..19449370, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19701313..19715442, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein C-I Neighboring gene apolipoprotein E Neighboring gene predicted gene, 38955 Neighboring gene nectin cell adhesion molecule 2 Neighboring gene STARR-seq mESC enhancer starr_18217 Neighboring gene STARR-seq mESC enhancer starr_18218 Neighboring gene predicted gene, 34744 Neighboring gene basal cell adhesion molecule Neighboring gene STARR-seq mESC enhancer starr_18221

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a 35-kDa mouse mitochondrial outer membrane protein MOM35 with high homology to Tom40. Rivera IL, et al. J Bioenerg Biomembr, 2000 Feb. PMID 11768756
    2. Genetic identity and differential expression of p38.5 (Haymaker) in human malignant and nonmalignant cells. Das B, et al. Int J Cancer, 2001 Dec 15. PMID 11745481
    3. TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease. Bender A, et al. PLoS One, 2013. PMID 23626796, Free PMC Article
    4. Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria. Hilander T, et al. Nucleic Acids Res, 2018 Jan 25. PMID 29228266, Free PMC Article
    5. Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Ishihara N, et al. Nat Cell Biol, 2009 Aug. PMID 19578372

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.
      Title: TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.
    2. the interaction of alpha-Syn with the mitochondrial protein import machinery, in particular Tom40, might be an upstream event in alpha-Syn-induced neurotoxicity.
      Title: TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.
    3. imported into the outer mitochondrial membrane
      Title: Cloning and characterization of a 35-kDa mouse mitochondrial outer membrane protein MOM35 with high homology to Tom40.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118268

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables preprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial outer membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial outer membrane translocase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import receptor subunit TOM40 homolog
    Names
    haymaker protein
    mitochondrial outer membrane protein 35
    mitochondrial outer membrane protein of 35 kDa
    translocase of outer membrane 40 kDa subunit homolog
    translocase of outer mitochondrial membrane 40 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109748.1 → NP_001103218.1  mitochondrial import receptor subunit TOM40 homolog

      See identical proteins and their annotated locations for NP_001103218.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK150019, AK165173, AW493492, BY231811
      Consensus CDS
      CCDS52062.1
      UniProtKB/Swiss-Prot
      Q3TBZ2, Q3TQA1, Q8VI26, Q8VI27, Q9QYA2, Q9Z2N1
      Related
      ENSMUSP00000032555.10, ENSMUST00000032555.10
      Conserved Domains (1) summary
      cd07305
      Location:77 → 361
      Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)

    2. NM_016871.2 → NP_058567.2  mitochondrial import receptor subunit TOM40 homolog

      See identical proteins and their annotated locations for NP_058567.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK165173, AW493492, BY231811
      Consensus CDS
      CCDS52062.1
      UniProtKB/Swiss-Prot
      Q3TBZ2, Q3TQA1, Q8VI26, Q8VI27, Q9QYA2, Q9Z2N1
      Related
      ENSMUSP00000104090.5, ENSMUST00000093552.12
      Conserved Domains (1) summary
      cd07305
      Location:77 → 361
      Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19435238..19449370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242769.2 → XP_030098629.1  mitochondrial import receptor subunit TOM40 homolog isoform X1

      Conserved Domains (1) summary
      cd07305
      Location:1 → 208
      Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYA2.3 GenPept UniProtKB/Swiss-Prot:Q9QYA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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