Atp2a3 ATPase, Ca++ transporting, ubiquitous [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp2a3provided by MGI
Official Full Name: ATPase, Ca++ transporting, ubiquitousprovided by MGI
Primary source: MGI:MGI:1194503
See related: Ensembl:ENSMUSG00000020788 AllianceGenome:MGI:1194503
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Serca3; SERCA3b
Summary: Enables calcium ion binding activity. Predicted to be involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; calcium ion transport from cytosol to endoplasmic reticulum; and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Predicted to act upstream of or within calcium ion transport. Located in endoplasmic reticulum. Orthologous to human ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 314.1), thymus adult (RPKM 123.3) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 45.0 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (72851995..72883869)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (72961169..72993043)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NAADP/SERCA3-Dependent Ca(2+) Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation.
Title: NAADP/SERCA3-Dependent Ca(2+) Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation.
SERCA3-dependent Ca(2+) stores control a specific ADP secretion pathway.
Title: Full activation of mouse platelets requires ADP secretion regulated by SERCA3 ATPase-dependent calcium stores.
ANP counter-regulates cardiac MR activation in hypertensive heart disease. An imbalance in cardiac ANP/GC-A (inhibition) and aldosterone/MR signaling (augmentation) favors adverse cardiac remodeling in chronic pressure overload.
Title: Atrial natriuretic peptide locally counteracts the deleterious effects of cardiomyocyte mineralocorticoid receptor activation.
This study evaluated the role of SERCA2b and SERCA3 in the control of the free calcium concentration in the endoplasmic reticulum and the role of SERCA3 in the control of insulin secretion.
Title: Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic β-cells: interplay with cell metabolism and [Ca2+]c and role of SERCA2b and SERCA3.
Ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells
Title: SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells.
identification of promoter region and binding site for Ets-1 in mouse SERCA3
Title: Basal transcription of the mouse sarco(endo)plasmic reticulum Ca2+-ATPase type 3 gene in endothelial cells is controlled by Ets-1 and Sp1.
regulation in insulin-secreting beta-cells by insulin receptor substrate 1
Title: Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells.
IRS-1 modulation of insulin secretion is associated with Ca(2+) signaling and expression of SERCA-2b and -3 genes in pancreatic islets. Direct link between insulin resistance and defective insulin secretion.
Title: Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U49394 (e-PCR)
- UniSTS:125760

U49393 (e-PCR)
- UniSTS:163505

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	ISO Inferred from Sequence Orthology more info
enables calcium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables calcium-dependent ATPase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport from cytosol to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of receptor binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in organelle membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sarcoplasmic/endoplasmic reticulum calcium ATPase 3

Names: SR Ca(2+)-ATPase 3; calcium pump 3; sarco /endoplasmic reticulum Ca2+ -ATPase; sarcoendoplasmic reticulum Ca2+ ATPase type 3

NP_001156808.1

EC 7.2.2.10

NP_001156809.1

EC 7.2.2.10

NP_058025.2

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163336.1 → NP_001156808.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform a

See identical proteins and their annotated locations for NP_001156808.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AK089487, AK152999, AK155904, BY549777

Consensus CDS

CCDS48843.1

UniProtKB/Swiss-Prot

O70625, Q64517, Q64518, Q8VD16

UniProtKB/TrEMBL

Q3U1K2, Q8R0X5

Related

ENSMUSP00000104125.3, ENSMUST00000108485.9

Conserved Domains (1) summary

cd02083
Location:5 → 989

P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
NM_001163337.1 → NP_001156809.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 3 encodes isoform c, which is longer and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AK089487, AK152999, AK155904, AL670399, BY549777, U49393

Consensus CDS

CCDS48842.1

UniProtKB/TrEMBL

E9Q559, Q3U1K2

Related

ENSMUSP00000127036.2, ENSMUST00000163326.8

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)
NM_016745.3 → NP_058025.2 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform b

See identical proteins and their annotated locations for NP_058025.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 2 encodes isoform b, which is longer and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AK089487, AK152999, AK155904, BY549777, U49393

Consensus CDS

CCDS24991.1

UniProtKB/TrEMBL

B1ATS5

Related

ENSMUSP00000021142.8, ENSMUST00000021142.8

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)