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    Tax1bp1 Tax1 (human T cell leukemia virus type I) binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 52440, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tax1bp1provided by MGI
    Official Full Name
    Tax1 (human T cell leukemia virus type I) binding protein 1provided by MGI
    Primary source
    MGI:MGI:1289308
    See related
    Ensembl:ENSMUSG00000004535 AllianceGenome:MGI:1289308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T6bp; TXBP151; D6Ertd404e; D6Ertd772e; 1200003J11Rik; 1700069J21Rik
    Summary
    Enables kinase binding activity. Involved in negative regulation of NF-kappaB transcription factor activity. Is expressed in central nervous system; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human TAX1BP1 (Tax1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 37.5), testis adult (RPKM 35.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B3; 6 25.7 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52690677..52743765)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52713692..52766780)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxyisobutyrate dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E536 Neighboring gene predicted gene, 24355 Neighboring gene STARR-positive B cell enhancer ABC_E8104 Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:52767269-52767470 Neighboring gene JAZF zinc finger 1 Neighboring gene predicted gene, 52904 Neighboring gene STARR-seq mESC enhancer starr_15910 Neighboring gene STARR-seq mESC enhancer starr_15912 Neighboring gene predicted gene, 52903

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multifaceted roles of TAX1BP1 in autophagy. White J, et al. Autophagy, 2023 Jan. PMID 35470757, Free PMC Article
    2. Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis. Waidmann O, et al. Sci Rep, 2020 Oct 1. PMID 33004985, Free PMC Article
    3. TAX1BP1 overexpression attenuates cardiac dysfunction and remodeling in STZ-induced diabetic cardiomyopathy in mice by regulating autophagy. Xiao Y, et al. Biochim Biophys Acta Mol Basis Dis, 2018 May. PMID 29476905
    4. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Whang MI, et al. Immunity, 2017 Mar 21. PMID 28314591, Free PMC Article
    5. Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1. Matsushita N, et al. Sci Rep, 2016 Aug 12. PMID 27515252, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAX1BP1 downregulation by STAT3 in cardiac fibroblasts contributes to diabetes-induced heart failure with preserved ejection fraction.
      Title: TAX1BP1 downregulation by STAT3 in cardiac fibroblasts contributes to diabetes-induced heart failure with preserved ejection fraction.
    2. Multifaceted roles of TAX1BP1 in autophagy.
      Title: Multifaceted roles of TAX1BP1 in autophagy.
    3. Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
      Title: Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
    4. Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis.
      Title: Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis.
    5. Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
      Title: Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
    6. TAX1BP1 overexpression promoted autophagic flux, as demonstrated by increased LC3-RFP fluorescence in vitro. Furthermore, the autophagy inhibitor 3-MA abolished the protective effects of TAX1BP1 in vivo.
      Title: TAX1BP1 overexpression attenuates cardiac dysfunction and remodeling in STZ-induced diabetic cardiomyopathy in mice by regulating autophagy.
    7. These findings show that TAX1BP1 restricts ERK activation and Blimp-1 expression and regulates germinal center formation.
      Title: Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1.
    8. These studies reveal that TAX1BP1 drives a specialized form of autophagy, providing critical amino acids that activate mTOR and enable the metabolic transition of activated T cells.
      Title: The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells.
    9. The induction of antibodies to an AQP4 epitope in mice immunized with the TAX1BP1-derived peptide suggests that a latent HTLV-1 infection could lead to TAX1BP1 antigen presentation and the production of anti-AQP4 antibodies in human neuromyelitis optica.
      Title: Immunization of mice with a peptide derived from the HTLV-1 TAX1BP1 protein induces cross-reactive antibodies against aquaporin 4.
    10. Antibiotics-induced 'germ free' status or the additional MyD88 deficiency significantly ameliorated TAX1BP1-KO mice's inflammatory lesions
      Title: Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytoplasmic pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tax1-binding protein 1 homolog
    Names
    TRAF6-binding protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355595.1 → NP_001342524.1  tax1-binding protein 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC099741, AC117212, BP754065
      Conserved Domains (1) summary
      cl25732
      Location:17 → 398
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_001355596.1 → NP_001342525.1  tax1-binding protein 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC099741, AC117212, BP754065
      Consensus CDS
      CCDS39490.1
      UniProtKB/Swiss-Prot
      Q3UKC1, Q91YT6, Q9CVF0, Q9DC45
      Conserved Domains (1) summary
      cl25732
      Location:17 → 460
      SMC_N; RecF/RecN/SMC N terminal domain

    3. NM_025816.3 → NP_080092.2  tax1-binding protein 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_080092.2

      Status: VALIDATED

      Source sequence(s)
      AC099741, AK146076, BP754065
      Consensus CDS
      CCDS39490.1
      UniProtKB/Swiss-Prot
      Q3UKC1, Q91YT6, Q9CVF0, Q9DC45
      Related
      ENSMUSP00000079548.5, ENSMUST00000080723.11
      Conserved Domains (1) summary
      cl25732
      Location:17 → 460
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      52690677..52743765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506370.5 → XP_006506433.1  tax1-binding protein 1 homolog isoform X1

      Conserved Domains (4) summary
      COG4372
      Location:338 → 645
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      pfam07888
      Location:125 → 408
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam17751
      Location:17 → 120
      SKICH; SKICH domain
      pfam18112
      Location:704 → 730
      Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UKC1.2 GenPept UniProtKB/Swiss-Prot:Q3UKC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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