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    Rcn3 reticulocalbin 3, EF-hand calcium binding domain [ Mus musculus (house mouse) ]

    Gene ID: 52377, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rcn3provided by MGI
    Official Full Name
    reticulocalbin 3, EF-hand calcium binding domainprovided by MGI
    Primary source
    MGI:MGI:1277122
    See related
    Ensembl:ENSMUSG00000019539 AllianceGenome:MGI:1277122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RLP49; D7Ertd671e; 6030455P07Rik; D530026G20Rik
    Summary
    Predicted to enable calcium ion binding activity. Involved in several processes, including ERAD pathway; phospholipid homeostasis; and surfactant homeostasis. Located in endoplasmic reticulum. Is expressed in several structures, including aorta; brain; gut gland; reproductive system; and trachea. Orthologous to human RCN3 (reticulocalbin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 194.2), ovary adult (RPKM 178.1) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B3; 7 29.11 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44732338..44741746, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45082914..45092322, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2235 Neighboring gene proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52317657-52317840 Neighboring gene nitric oxide synthase interacting protein Neighboring gene Fc fragment of IgG receptor and transporter Neighboring gene STARR-seq mESC enhancer starr_18830 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52376860-52377101 Neighboring gene predicted gene 45552 Neighboring gene microRNA 150

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reticulocalbin 3 is involved in postnatal tendon development by regulating collagen fibrillogenesis and cellular maturation. Park NR, et al. Sci Rep, 2021 May 25. PMID 34035379, Free PMC Article
    2. Reticulocalbin 3 deficiency in alveolar epithelium attenuated LPS-induced ALI via NF-κB signaling. Shi X, et al. Am J Physiol Lung Cell Mol Physiol, 2021 Apr 1. PMID 33625944
    3. Reticulocalbin 3 Deficiency in Alveolar Epithelium Exacerbated Bleomycin-induced Pulmonary Fibrosis. Jin J, et al. Am J Respir Cell Mol Biol, 2018 Sep. PMID 29676583
    4. Evolutionary diversification of the BetaM interactome acquired through co-option of the ATP1B4 gene in placental mammals. Korneenko TV, et al. Sci Rep, 2016 Mar 4. PMID 26939788, Free PMC Article
    5. Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. Jin J, et al. Am J Respir Cell Mol Biol, 2016 Mar. PMID 26252542

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102610

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lung epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in surfactant homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    reticulocalbin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355045.1 → NP_001341974.1  reticulocalbin-3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC126256
      Consensus CDS
      CCDS21229.1
      UniProtKB/Swiss-Prot
      Q58E50, Q8BH97, Q8R137, Q99K35, Q9CTD4
      UniProtKB/TrEMBL
      A0A1B0GR86
      Related
      ENSMUSP00000148227.2, ENSMUST00000211352.2
      Conserved Domains (1) summary
      cd16230
      Location:44 → 311
      EFh_CREC_RCN3; EF-hand, calcium binding motif, found in reticulocalbin-3 (RCN-3)

    2. NM_026555.2 → NP_080831.2  reticulocalbin-3 precursor

      See identical proteins and their annotated locations for NP_080831.2

      Status: VALIDATED

      Source sequence(s)
      AK077943, AV129283, BY248337
      Consensus CDS
      CCDS21229.1
      UniProtKB/Swiss-Prot
      Q58E50, Q8BH97, Q8R137, Q99K35, Q9CTD4
      UniProtKB/TrEMBL
      A0A1B0GR86
      Related
      ENSMUSP00000019683.4, ENSMUST00000019683.11
      Conserved Domains (1) summary
      cd16230
      Location:44 → 311
      EFh_CREC_RCN3; EF-hand, calcium binding motif, found in reticulocalbin-3 (RCN-3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44732338..44741746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540987.4 → XP_006541050.1  reticulocalbin-3 isoform X1

      See identical proteins and their annotated locations for XP_006541050.1

      UniProtKB/Swiss-Prot
      Q58E50, Q8BH97, Q8R137, Q99K35, Q9CTD4
      UniProtKB/TrEMBL
      A0A1B0GR86
      Related
      ENSMUSP00000147341.2, ENSMUST00000210469.2
      Conserved Domains (1) summary
      cd16230
      Location:44 → 311
      EFh_CREC_RCN3; EF-hand, calcium binding motif, found in reticulocalbin-3 (RCN-3)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH97.1 GenPept UniProtKB/Swiss-Prot:Q8BH97

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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