Tmod2 tropomodulin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmod2provided by MGI
Official Full Name: tropomodulin 2provided by MGI
Primary source: MGI:MGI:1355335
See related: Ensembl:ENSMUSG00000032186 AllianceGenome:MGI:1355335
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NTMOD; N-Tmod
Summary: Predicted to enable actin binding activity and tropomyosin binding activity. Acts upstream of or within learning or memory; neuron-neuron synaptic transmission; and positive regulation of G protein-coupled receptor signaling pathway. Predicted to be located in growth cone. Predicted to be active in striated muscle thin filament. Is expressed in several structures, including adrenal gland; cardiovascular system; genitourinary system; gut; and nervous system. Orthologous to human TMOD2 (tropomodulin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 26.5), cortex adult (RPKM 21.6) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 42.31 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (75472903..75518620, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (75565621..75611342, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of Tmod2 protein's leucine rich repeat domain in the formation of neurite-like processes
Title: Role of tropomodulin's leucine rich repeat domain in the formation of neurite-like processes.
Tmod2 plays a role in behavior, learning, memory, and synaptic plasticity.
Title: Mice lacking Tropomodulin-2 show enhanced long-term potentiation, hyperactivity, and deficits in learning and memory.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tropomyosin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in myofibril assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron-neuron synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pointed-end actin filament capping	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info
is_active_in striated muscle thin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tropomodulin-2

Names: neural tropomodulin; neuronal tropomodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038710.1 → NP_001033799.1 tropomodulin-2

See identical proteins and their annotated locations for NP_001033799.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.

Source sequence(s)

AC123832, AK079077, BC052227

Consensus CDS

CCDS23345.1

UniProtKB/Swiss-Prot

Q3UH50, Q8BGX9, Q9CUK4, Q9JKK7, Q9JLH9

Related

ENSMUSP00000150750.2, ENSMUST00000215036.2

Conserved Domains (2) summary

pfam03250
Location:5 → 146

Tropomodulin

cl39015
Location:215 → 323

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_016711.3 → NP_057920.2 tropomodulin-2

See identical proteins and their annotated locations for NP_057920.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform.

Source sequence(s)

AC123832, AK079077, AK147581

Consensus CDS

CCDS23345.1

UniProtKB/Swiss-Prot

Q3UH50, Q8BGX9, Q9CUK4, Q9JKK7, Q9JLH9

Related

ENSMUSP00000096152.3, ENSMUST00000098552.10

Conserved Domains (2) summary

pfam03250
Location:5 → 146

Tropomodulin

cl39015
Location:215 → 323

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

75472903..75518620 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511268.4 → XP_006511331.1 tropomodulin-2 isoform X1

See identical proteins and their annotated locations for XP_006511331.1

UniProtKB/Swiss-Prot

Q3UH50, Q8BGX9, Q9CUK4, Q9JKK7, Q9JLH9

Related

ENSMUSP00000150413.2, ENSMUST00000215614.2

Conserved Domains (2) summary

pfam03250
Location:5 → 146

Tropomodulin

cl39015
Location:215 → 323

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_030244444.2 → XP_030100304.1 tropomodulin-2 isoform X1

UniProtKB/Swiss-Prot

Q3UH50, Q8BGX9, Q9CUK4, Q9JKK7, Q9JLH9

Conserved Domains (2) summary

pfam03250
Location:5 → 146

Tropomodulin

cl39015
Location:215 → 323

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_036155101.1 → XP_036010994.1 tropomodulin-2 isoform X1

UniProtKB/Swiss-Prot

Q3UH50, Q8BGX9, Q9CUK4, Q9JKK7, Q9JLH9

Conserved Domains (2) summary

pfam03250
Location:5 → 146

Tropomodulin

cl39015
Location:215 → 323

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_006511267.5 → XP_006511330.1 tropomodulin-2 isoform X1

See identical proteins and their annotated locations for XP_006511330.1

UniProtKB/Swiss-Prot

Q3UH50, Q8BGX9, Q9CUK4, Q9JKK7, Q9JLH9

Related

ENSMUSP00000126739.2, ENSMUST00000164100.2

Conserved Domains (2) summary

pfam03250
Location:5 → 146

Tropomodulin

cl39015
Location:215 → 323

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...