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    Fbxo6 F-box protein 6 [ Mus musculus (house mouse) ]

    Gene ID: 50762, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Fbxo6provided by MGI
    Official Full Name
    F-box protein 6provided by MGI
    Primary source
    MGI:MGI:1354743
    See related
    Ensembl:ENSMUSG00000055401 AllianceGenome:MGI:1354743
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBG2; Fbs2; Fbx6b; Fbxo6b
    Summary
    Enables carbohydrate binding activity. Contributes to ubiquitin protein ligase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and ubiquitin-dependent ERAD pathway. Acts upstream of or within glycoprotein catabolic process. Located in endoplasmic reticulum quality control compartment. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and lung. Orthologous to human FBXO6 (F-box protein 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 22.6), liver adult (RPKM 18.1) and 28 other tissues See more
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    Genomic context

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    Location:
    4 E2; 4 78.67 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148230173..148236592, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148145716..148152135, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12067 Neighboring gene STARR-seq mESC enhancer starr_12068 Neighboring gene angiotensin II, type I receptor-associated protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:147472153-147472360 Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene STARR-positive B cell enhancer ABC_E2146 Neighboring gene MAD2 mitotic arrest deficient-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E4728 Neighboring gene microRNA 7022 Neighboring gene STARR-positive B cell enhancer ABC_E3553 Neighboring gene F-box protein 44 Neighboring gene F-box protein 2 Neighboring gene STARR-seq mESC enhancer starr_12077 Neighboring gene predicted gene, 32603

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival. Cen M, et al. J Med Virol, 2023 Jan. PMID 36217277, Free PMC Article
    2. Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase. Yoshida Y, et al. Proc Natl Acad Sci U S A, 2021 Jul 6. PMID 34215698, Free PMC Article
    3. Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene. Bliskovsky V, et al. Proc Natl Acad Sci U S A, 2003 Dec 9. PMID 14634209, Free PMC Article
    4. Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. Yoshida Y, et al. J Biol Chem, 2003 Oct 31. PMID 12939278
    5. A shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins. Shenkman M, et al. J Biol Chem, 2013 Jan 25. PMID 23233672, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.
      Title: Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.
    2. FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival.
      Title: FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival.
    3. Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase.
      Title: Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase.
    4. Fbs2 is a novel member of F-box protein family that recognizes N-glycans and plays a role in ERAD
      Title: Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (5) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ubiquitin protein ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycoprotein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum quality control compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum quality control compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box only protein 6
    Names
    F-box only protein 6b
    F-box protein that recognizes sugar chains 2
    F-box/G-domain protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163704.1 → NP_001157176.1  F-box only protein 6

      See identical proteins and their annotated locations for NP_001157176.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AK150612, AK165867, BB854497
      Consensus CDS
      CCDS18933.1
      UniProtKB/Swiss-Prot
      A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4
      UniProtKB/TrEMBL
      Z4YN00
      Related
      ENSMUSP00000030858.8, ENSMUST00000030858.14
      Conserved Domains (2) summary
      pfam04300
      Location:70 → 248
      FBA; F-box associated region
      pfam12937
      Location:4 → 47
      F-box-like

    2. NM_001163705.1 → NP_001157177.1  F-box only protein 6

      See identical proteins and their annotated locations for NP_001157177.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AK165867, AK171483, BB854497, BY260050
      Consensus CDS
      CCDS18933.1
      UniProtKB/Swiss-Prot
      A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4
      UniProtKB/TrEMBL
      Z4YN00
      Conserved Domains (2) summary
      pfam04300
      Location:70 → 248
      FBA; F-box associated region
      pfam12937
      Location:4 → 47
      F-box-like

    3. NM_001163706.1 → NP_001157178.1  F-box only protein 6

      See identical proteins and their annotated locations for NP_001157178.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AK165867, AK171483
      Consensus CDS
      CCDS18933.1
      UniProtKB/Swiss-Prot
      A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4
      UniProtKB/TrEMBL
      Z4YN00
      Related
      ENSMUSP00000062348.6, ENSMUST00000056965.12
      Conserved Domains (2) summary
      pfam04300
      Location:70 → 248
      FBA; F-box associated region
      pfam12937
      Location:4 → 47
      F-box-like

    4. NM_001163707.1 → NP_001157179.1  F-box only protein 6

      See identical proteins and their annotated locations for NP_001157179.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AK165867, AK171483, BY164736
      Consensus CDS
      CCDS18933.1
      UniProtKB/Swiss-Prot
      A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4
      UniProtKB/TrEMBL
      Z4YN00
      Related
      ENSMUSP00000130188.2, ENSMUST00000168503.8
      Conserved Domains (2) summary
      pfam04300
      Location:70 → 248
      FBA; F-box associated region
      pfam12937
      Location:4 → 47
      F-box-like

    5. NM_015797.4 → NP_056612.1  F-box only protein 6

      See identical proteins and their annotated locations for NP_056612.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-6 encode the same protein.
      Source sequence(s)
      AK165867, BB854497
      Consensus CDS
      CCDS18933.1
      UniProtKB/Swiss-Prot
      A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4
      UniProtKB/TrEMBL
      Z4YN00
      Related
      ENSMUSP00000101331.2, ENSMUST00000105706.8
      Conserved Domains (2) summary
      pfam04300
      Location:70 → 248
      FBA; F-box associated region
      pfam12937
      Location:4 → 47
      F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148230173..148236592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZN4.1 GenPept UniProtKB/Swiss-Prot:Q9QZN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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