Ebi3 Epstein-Barr virus induced gene 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ebi3provided by MGI
Official Full Name: Epstein-Barr virus induced gene 3provided by MGI
Primary source: MGI:MGI:1354171
See related: Ensembl:ENSMUSG00000003206 AllianceGenome:MGI:1354171
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EBI-3; IL-27
Summary: Enables interleukin-27 receptor binding activity. Involved in T cell proliferation. Predicted to be located in extracellular space and membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including decidua; extraembryonic component; sensory organ; and skeleton. Orthologous to human EBI3 (Epstein-Barr virus induced 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 18.1), mammary gland adult (RPKM 10.2) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.08 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (56259623..56264022)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (55952623..55957022)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ebi3 knockout aggravates experimental periodontitis via Th17 polarization.
Title: Ebi3 knockout aggravates experimental periodontitis via Th17 polarization.
IL-35 subunit EBI3 alleviates bleomycin-induced pulmonary fibrosis via suppressing DNA enrichment of STAT3.
Title: IL-35 subunit EBI3 alleviates bleomycin-induced pulmonary fibrosis via suppressing DNA enrichment of STAT3.
Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis.
Title: Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis.
Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3.
Title: Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3.
EBV-induced gene 3 augments IL-23Ralpha protein expression through a chaperone calnexin.
Title: EBV-induced gene 3 augments IL-23Rα protein expression through a chaperone calnexin.
Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3.
Title: Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3.
This study evaluated changes in new and maintenance DNA methylation profiles in the liver after 55 days of infection with Schistosoma mansoni.
Title: Epigenetic and parasitological parameters are modulated in EBi3-/- mice infected with Schistosoma mansoni.
IL-35 subunits (EBI3 and p35), which are mainly expressed in regulatory T cells, were upregulated in mice after myocardial infarction. IL-35 reduces cardiac rupture, improves wound healing, and attenuates cardiac remodeling after MI by promoting reparative CX3CR1(+)Ly6C(low) macrophage survival.
Title: Interleukin-35 Promotes Macrophage Survival and Improves Wound Healing After Myocardial Infarction in Mice.
we propose a novel mechanism for accumulating intracellular EBI3 and its regulation of macrophage apoptosis in response to virulent M. tb.
Title: Accumulation of EBI3 induced by virulent Mycobacterium tuberculosis inhibits apoptosis in murine macrophages.
In regulatory B cells, BATF, IFN regulatory factor, and IRF-8 transcription factors were recruited and bound to AP1-IRF-composite elements of il12a, ebi3, and/or il10 loci.
Title: Production of IL-35 by Bregs is mediated through binding of BATF-IRF-4-IRF-8 complex to il12a and ebi3 promoter elements.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation
Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ebi3 (e-PCR), detects polymorphism
- UniSTS:532616

Il27 (e-PCR), detects polymorphism
- UniSTS:532619

AF013114 (e-PCR)
- UniSTS:160681

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-27 receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-27 subunit beta

Names: IL-27 subunit beta; IL-27B; epstein-Barr virus-induced gene 3 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015766.2 → NP_056581.1 interleukin-27 subunit beta precursor

See identical proteins and their annotated locations for NP_056581.1

Status: VALIDATED

Source sequence(s)

AW495532, BI134394, BY134465, CX240802

Consensus CDS

CCDS28888.1

UniProtKB/Swiss-Prot

O35228

UniProtKB/TrEMBL

Q3U1K3

Related

ENSMUSP00000003274.7, ENSMUST00000003274.8

Conserved Domains (1) summary

cd00063
Location:128 → 216

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

56259623..56264022

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524599.5 → XP_006524662.1 interleukin-27 subunit beta isoform X1

Conserved Domains (1) summary

cd00063
Location:27 → 115

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...