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    Hspa14 heat shock protein 14 [ Mus musculus (house mouse) ]

    Gene ID: 50497, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hspa14provided by MGI
    Official Full Name
    heat shock protein 14provided by MGI
    Primary source
    MGI:MGI:1354164
    See related
    Ensembl:ENSMUSG00000109865 AllianceGenome:MGI:1354164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    70kDa; NST-1; hsr.1; HSP70L1; Hsp70-4
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to be active in cytosol; nucleus; and plasma membrane. Predicted to colocalize with ribosome. Orthologous to human HSPA14 (heat shock protein family A (Hsp70) member 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 10.3), liver E14 (RPKM 9.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hspa14 in Genome Data Viewer
    Location:
    2 A1; 2 1.97 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3489891..3513851, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3488854..3512814, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5880 Neighboring gene meiosis expressed gene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:3341062-3341360 Neighboring gene DNA cross-link repair 1C Neighboring gene STARR-seq mESC enhancer starr_03514 Neighboring gene suppressor of variegation 3-9 2 Neighboring gene STARR-seq mESC enhancer starr_03515 Neighboring gene predicted gene, 54099 Neighboring gene Myb/SANT DNA binding domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E272 Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response. Fang H, et al. J Biol Chem, 2011 Sep 2. PMID 21730052, Free PMC Article
    2. Sak kinase gene structure and transcriptional regulation. Hudson JW, et al. Gene, 2000 Jan 4. PMID 10607900
    3. Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Sferruzzi-Perri AN, et al. Biol Reprod, 2009 Jul. PMID 19228596, Free PMC Article
    4. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TLR4 is a key receptor mediating the interaction of Hsp70L1 with DCs and subsequently enhancing the induction of Th1 immune response by Hsp70L1/antigen fusion protein
      Title: Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heat shock 70 kDa protein 14
    Names
    heat shock 70kDa protein 14
    heat shock protein 4
    heat shock protein, 70 kDa 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355397.1 → NP_001342326.1  heat shock 70 kDa protein 14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL732620
      Conserved Domains (1) summary
      cl17037
      Location:27 → 329
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. NM_015765.2 → NP_056580.2  heat shock 70 kDa protein 14 isoform 1

      See identical proteins and their annotated locations for NP_056580.2

      Status: VALIDATED

      Source sequence(s)
      BI734146, BU505607, BY121986, U08215
      Consensus CDS
      CCDS15653.1
      UniProtKB/Swiss-Prot
      A2AJH7, Q3U5W7, Q60637, Q99M31
      Related
      ENSMUSP00000027961.6, ENSMUST00000027961.12
      Conserved Domains (1) summary
      cd10238
      Location:2 → 376
      HSPA14-like_NBD; Nucleotide-binding domain of human HSPA14 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      3489891..3513851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037542.1: Suppressed sequence

      Description
      NM_001037542.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NR_103465.1: Suppressed sequence

      Description
      NR_103465.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.

    3. NR_149715.1: Suppressed sequence

      Description
      NR_149715.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99M31.2 GenPept UniProtKB/Swiss-Prot:Q99M31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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