Siva1 SIVA1, apoptosis-inducing factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Siva1provided by MGI
Official Full Name: SIVA1, apoptosis-inducing factorprovided by MGI
Primary source: MGI:MGI:1353606
See related: Ensembl:ENSMUSG00000064326 AllianceGenome:MGI:1353606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Siva; CD27bp
Summary: Enables CD27 receptor binding activity; tumor necrosis factor receptor binding activity; and virus receptor activity. Predicted to be involved in several processes, including activation-induced cell death of T cells; negative regulation of NF-kappaB transcription factor activity; and positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to act upstream of or within apoptotic process. Predicted to be located in mitochondrion and nucleoplasm. Is expressed in cerebral cortex ventricular layer. Orthologous to human SIVA1 (SIVA1 apoptosis inducing factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 53.8), ovary adult (RPKM 52.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 61.2 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (112611262..112615586)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (112644828..112649152)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Siva plays a critical role in mouse embryonic development.
Title: Siva plays a critical role in mouse embryonic development.
SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
Title: SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
These findings collectively reveal a novel role for the p53 target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53.
Title: The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.
Data indicate that p53 target Siva is pivotal in regulating apoptosis in the pathology of renal ischemia reperfusion injury.
Title: p53 target Siva regulates apoptosis in ischemic kidneys.
Data show that SLIMMER delayed Siva-1-dependent apoptosis in C2C12 myoblasts.
Title: SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis.
lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival
Title: The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival.
SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1
Title: The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1.
Siva's expression pattern suggests that it plays an instructive role in apoptosis, and accordingly, we demonstrate that Siva is essential for p53-dependent apoptosis in cerebellar granule neurons.
Title: Siva is an apoptosis-selective p53 target gene important for neuronal cell death.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CD27 receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CD27 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables CD27 receptor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables virus receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation-induced cell death of T cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: apoptosis regulatory protein Siva

Names: CD27-binding protein; Cd27 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161737.1 → NP_001155209.1 apoptosis regulatory protein Siva isoform 2

See identical proteins and their annotated locations for NP_001155209.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC124373, AF033112, AW060433, CB524656

Consensus CDS

CCDS49189.1

UniProtKB/Swiss-Prot

O54926

Related

ENSMUSP00000105377.4, ENSMUST00000109755.5

Conserved Domains (1) summary

pfam05458
Location:1 → 110

Siva; Cd27 binding protein (Siva)
NM_013929.2 → NP_038957.2 apoptosis regulatory protein Siva isoform 1

See identical proteins and their annotated locations for NP_038957.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC124373, AK017570, AW060433, CB524656

Consensus CDS

CCDS26193.1

UniProtKB/Swiss-Prot

O54926, Q3U6J2, Q921I8, Q9CWL1, Q9R1Q0, Q9R1Q1

UniProtKB/TrEMBL

Q3TFC3

Related

ENSMUSP00000021728.5, ENSMUST00000021728.12

Conserved Domains (1) summary

pfam05458
Location:1 → 175

Siva; Cd27 binding protein (Siva)