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    Mlf2 myeloid leukemia factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 30853, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Mlf2provided by MGI
    Official Full Name
    myeloid leukemia factor 2provided by MGI
    Primary source
    MGI:MGI:1353554
    See related
    Ensembl:ENSMUSG00000030120 AllianceGenome:MGI:1353554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in regulation of transcription, DNA-templated. Located in nucleus. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human MLF2 (myeloid leukemia factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 196.7), adrenal adult (RPKM 170.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 F2; 6 59.17 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124908351..124913112)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124931388..124936149)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A230083G16 gene Neighboring gene STARR-seq mESC enhancer starr_17314 Neighboring gene parathymosin Neighboring gene predicted gene, 38896 Neighboring gene STARR-positive B cell enhancer ABC_E8969 Neighboring gene STARR-seq mESC enhancer starr_17317 Neighboring gene STARR-seq mESC enhancer starr_17318 Neighboring gene STARR-seq mESC enhancer starr_17319 Neighboring gene STARR-positive B cell enhancer ABC_E3682 Neighboring gene COP9 signalosome subunit 7A Neighboring gene predicted gene, 23851 Neighboring gene STARR-seq mESC enhancer starr_17320 Neighboring gene STARR-seq mESC enhancer starr_17322 Neighboring gene PILR alpha associated neural protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Teratogen-induced distortions in the classical NF-kappaB activation pathway: correlation with the ability of embryos to survive teratogenic stress. Molotski N, et al. Toxicol Appl Pharmacol, 2008 Jun 1. PMID 18395765
    2. G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. Zhang D, et al. J Biol Chem, 2008 Mar 28. PMID 18218630, Free PMC Article
    3. Chaperone protein HYPK interacts with the first 17 amino acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity. Choudhury KR, et al. Biochem Biophys Res Commun, 2015 Jan 2. PMID 25446099
    4. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article
    5. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myeloid leukemia factor 2
    Names
    Myelodysplasia-myeloid leukemia factor 2
    myeloid leukemia factor 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170341.1 → NP_001163812.1  myeloid leukemia factor 2

      See identical proteins and their annotated locations for NP_001163812.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AK143972, BF464435, BY286289
      Consensus CDS
      CCDS20538.1
      UniProtKB/Swiss-Prot
      Q99KX1
      UniProtKB/TrEMBL
      Q3UNV7, Q3URS8
      Related
      ENSMUSP00000135920.2, ENSMUST00000180095.4
      Conserved Domains (1) summary
      pfam10248
      Location:26 → 198
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    2. NM_145385.2 → NP_663360.1  myeloid leukemia factor 2

      See identical proteins and their annotated locations for NP_663360.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AK143972, BF464435, BY286289, CD560861
      Consensus CDS
      CCDS20538.1
      UniProtKB/Swiss-Prot
      Q99KX1
      UniProtKB/TrEMBL
      Q3UNV7, Q3URS8
      Related
      ENSMUSP00000032214.8, ENSMUST00000032214.14
      Conserved Domains (1) summary
      pfam10248
      Location:26 → 198
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      124908351..124913112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KX1.1 GenPept UniProtKB/Swiss-Prot:Q99KX1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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