Fbxl6 F-box and leucine-rich repeat protein 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxl6provided by MGI
Official Full Name: F-box and leucine-rich repeat protein 6provided by MGI
Primary source: MGI:MGI:1354705
See related: Ensembl:ENSMUSG00000022559 AllianceGenome:MGI:1354705
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fbl6
Summary: Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and entrainment of circadian clock by photoperiod. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Orthologous to human FBXL6 (F-box and leucine rich repeat protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 75.4), adrenal adult (RPKM 61.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 36.04 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (76419923..76422946, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (76535723..76538746, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated FBXL6 expression in hepatocytes activates VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver cancer metastasis in mice.
Title: Elevated FBXL6 expression in hepatocytes activates VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver cancer metastasis in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: F-box/LRR-repeat protein 6

Names: F-box protein FBL6; F-box protein containing leucine repeats 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013909.2 → NP_038937.2 F-box/LRR-repeat protein 6

See identical proteins and their annotated locations for NP_038937.2

Status: VALIDATED

Source sequence(s)

AF176522, AK040458, BC054377

Consensus CDS

CCDS49653.1

UniProtKB/Swiss-Prot

Q9JJD7, Q9QXW0

Related

ENSMUSP00000023219.8, ENSMUST00000023219.9

Conserved Domains (3) summary

cd09293
Location:171 → 390

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:188 → 213

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:105 → 155

F-box-like; F-box-like