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    Pde7b phosphodiesterase 7B [ Mus musculus (house mouse) ]

    Gene ID: 29863, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pde7bprovided by MGI
    Official Full Name
    phosphodiesterase 7Bprovided by MGI
    Primary source
    MGI:MGI:1352752
    See related
    Ensembl:ENSMUSG00000019990 AllianceGenome:MGI:1352752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Is expressed in several structures, including central nervous system; heart; integumental system; liver; and sensory organ. Orthologous to human PDE7B (phosphodiesterase 7B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 2.7), lung adult (RPKM 2.0) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pde7b in Genome Data Viewer
    Location:
    10 A3; 10 9.75 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (20272798..20600824, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (20397052..20725078, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6822 Neighboring gene STARR-seq mESC enhancer starr_25963 Neighboring gene mitochondrial fission regulator 2 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25964 Neighboring gene VISTA enhancer mm140 Neighboring gene STARR-positive B cell enhancer ABC_E1796 Neighboring gene STARR-seq mESC enhancer starr_25965 Neighboring gene F-box protein 34 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25966 Neighboring gene STARR-seq mESC enhancer starr_25967 Neighboring gene STARR-seq mESC enhancer starr_25968 Neighboring gene MYB binding protein (P160) 1a pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr10:20491677-20491977 Neighboring gene STARR-seq mESC enhancer starr_25969 Neighboring gene STARR-seq mESC enhancer starr_25970 Neighboring gene STARR-positive B cell enhancer mm9_chr10:20554956-20555257 Neighboring gene predicted gene, 33510 Neighboring gene predicted gene, 53617 Neighboring gene ribosomal protein S2, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice. Morales-Garcia JA, et al. Neurobiol Aging, 2015 Feb. PMID 25457552
    2. Lack of involvement of type 7 phosphodiesterase in an experimental model of asthma. Chevalier E, et al. Eur Respir J, 2012 Mar. PMID 22088971
    3. Identification of human PDE7B, a cAMP-specific phosphodiesterase. Sasaki T, et al. Biochem Biophys Res Commun, 2000 May 19. PMID 10814504
    4. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Hetman JM, et al. Proc Natl Acad Sci U S A, 2000 Jan 4. PMID 10618442, Free PMC Article
    5. Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Gardner C, et al. Biochem Biophys Res Commun, 2000 May 27. PMID 10872825

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3',5'-cyclic-AMP phosphodiesterase 7B
    Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 7B
    cAMP-specific phosphodiesterase 7B
    NP_001334295.1
    NP_038903.3
    XP_036011699.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347366.1 → NP_001334295.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC153845, AJ251859, AK035385, AK049910, CX215057
      Consensus CDS
      CCDS83686.1
      UniProtKB/TrEMBL
      E9PW23, E9Q0W7
      Related
      ENSMUSP00000132378.2, ENSMUST00000169404.8

    2. NM_013875.6 → NP_038903.3  3',5'-cyclic-AMP phosphodiesterase 7B isoform 2

      See identical proteins and their annotated locations for NP_038903.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and and contains alternate exons in the 5' coding region, compared to variant 1. These differences cause translation initiation at am alternate start codon and result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC153845, AJ251859, AK035385, BB627693, CX215057
      Consensus CDS
      CCDS35859.1
      UniProtKB/Swiss-Prot
      A1L3T2, Q9QXQ1
      UniProtKB/TrEMBL
      Q8CBS2
      Related
      ENSMUSP00000020165.8, ENSMUST00000020165.14
      Conserved Domains (1) summary
      pfam00233
      Location:172 → 392
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      20272798..20600824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155806.1 → XP_036011699.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X1

      Conserved Domains (1) summary
      pfam00233
      Location:65 → 299
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXQ1.1 GenPept UniProtKB/Swiss-Prot:Q9QXQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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