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    Ndrg2 N-myc downstream regulated gene 2 [ Mus musculus (house mouse) ]

    Gene ID: 29811, updated on 10-Mar-2024

    Summary

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    Official Symbol
    Ndrg2provided by MGI
    Official Full Name
    N-myc downstream regulated gene 2provided by MGI
    Primary source
    MGI:MGI:1352498
    See related
    Ensembl:ENSMUSG00000004558 AllianceGenome:MGI:1352498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ndr2; SYLD
    Summary
    Acts upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of smooth muscle cell proliferation; and regulation of cytokine production. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and respiratory system. Orthologous to human NDRG2 (NDRG family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 416.8), heart adult (RPKM 317.4) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 C2; 14 26.72 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52142738..52151463, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51905271..51914004, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 17 Neighboring gene solute carrier family 39 (zinc transporter), member 2 Neighboring gene tubulin polymerization-promoting protein family member 2 Neighboring gene ribonuclease, RNase A family, 13 (non-active)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen-glucose deprivation conditions. Xu J, et al. J Neuroinflammation, 2022 Dec 26. PMID 36572898, Free PMC Article
    2. N-myc Downstream-Regulated Gene 2 (Ndrg2): A Critical Mediator of Estrogen-Induced Neuroprotection Against Cerebral Ischemic Injury. Wang J, et al. Mol Neurobiol, 2022 Aug. PMID 35622273
    3. Abnormal social behavior and altered gene expression in mice lacking NDRG2. Takarada-Iemata M, et al. Neurosci Lett, 2021 Jan 19. PMID 33359046
    4. Overexpression of NDRG2 in skeletal muscle does not ameliorate the effects of stress in vivo. Mir BA, et al. Exp Physiol, 2020 Aug. PMID 32468595
    5. Suppression of NDRG2 alleviates brain injury after intracerebral hemorrhage through mitigating astrocyte-drived glutamate neurotoxicity via NF-κB/GLT1 signaling. Zhou J, et al. Brain Res, 2020 Feb 15. PMID 31843625

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NDRG2 alleviates photoreceptor apoptosis by regulating the STAT3/TIMP3/MMP pathway in mice with retinal degenerative disease.
      Title: NDRG2 alleviates photoreceptor apoptosis by regulating the STAT3/TIMP3/MMP pathway in mice with retinal degenerative disease.
    2. Reprogramming astrocytic NDRG2/NF-kappaB/C3 signaling restores the diabetes-associated cognitive dysfunction.
      Title: Reprogramming astrocytic NDRG2/NF-κB/C3 signaling restores the diabetes-associated cognitive dysfunction.
    3. ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis.
      Title: ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis.
    4. Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.
      Title: Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.
    5. N-myc Downstream-Regulated Gene 2 (Ndrg2): A Critical Mediator of Estrogen-Induced Neuroprotection Against Cerebral Ischemic Injury.
      Title: N-myc Downstream-Regulated Gene 2 (Ndrg2): A Critical Mediator of Estrogen-Induced Neuroprotection Against Cerebral Ischemic Injury.
    6. Transcription factor Kruppel-like factor 5-regulated N-myc downstream-regulated gene 2 reduces IL-1beta-induced chondrocyte inflammatory injury and extracellular matrix degradation.
      Title: Transcription factor Krüppel-like factor 5-regulated N-myc downstream-regulated gene 2 reduces IL-1β-induced chondrocyte inflammatory injury and extracellular matrix degradation.
    7. Long noncoding RNA MIR22HG promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-125a-5p that targets N-Myc downstream-regulated gene 2 in late-onset hypogonadism.
      Title: Long noncoding RNA MIR22HG promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-125a-5p that targets N-Myc downstream-regulated gene 2 in late-onset hypogonadism.
    8. Overexpression of NDRG2 in skeletal muscle does not ameliorate the effects of stress in vivo.
      Title: Overexpression of NDRG2 in skeletal muscle does not ameliorate the effects of stress in vivo.
    9. NDRG2 is expressed on enteric glia and altered in conditions of inflammation and oxygen glucose deprivation/reoxygenation.
      Title: NDRG2 is expressed on enteric glia and altered in conditions of inflammation and oxygen glucose deprivation/reoxygenation.
    10. NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis.
      Title: NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (52)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of platelet-derived growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of vascular endothelial growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of vascular associated smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein NDRG2
    Names
    N-myc downstream regulated 2
    N-myc downstream-regulated gene 2 protein
    protein Ndr2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145959.2 → NP_001139431.1  protein NDRG2 isoform 2

      See identical proteins and their annotated locations for NP_001139431.1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS49486.1
      UniProtKB/Swiss-Prot
      Q9QYG0
      Related
      ENSMUSP00000107259.4, ENSMUST00000111632.5
      Conserved Domains (1) summary
      pfam03096
      Location:26 → 304
      Ndr; Ndr family

    2. NM_001360264.2 → NP_001347193.1  protein NDRG2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Conserved Domains (1) summary
      pfam03096
      Location:43 → 321
      Ndr; Ndr family

    3. NM_001360265.2 → NP_001347194.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS27047.1
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Conserved Domains (1) summary
      pfam03096
      Location:40 → 318
      Ndr; Ndr family

    4. NM_001360266.2 → NP_001347195.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS27047.1
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Conserved Domains (1) summary
      pfam03096
      Location:40 → 318
      Ndr; Ndr family

    5. NM_001360267.2 → NP_001347196.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS27047.1
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Conserved Domains (1) summary
      pfam03096
      Location:40 → 318
      Ndr; Ndr family

    6. NM_001360268.2 → NP_001347197.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS27047.1
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Conserved Domains (1) summary
      pfam03096
      Location:40 → 318
      Ndr; Ndr family

    7. NM_001360269.2 → NP_001347198.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS27047.1
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Conserved Domains (1) summary
      pfam03096
      Location:40 → 318
      Ndr; Ndr family

    8. NM_001360270.2 → NP_001347199.1  protein NDRG2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Conserved Domains (1) summary
      pfam03096
      Location:29 → 307
      Ndr; Ndr family

    9. NM_001360271.2 → NP_001347200.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS49486.1
      Conserved Domains (1) summary
      pfam03096
      Location:26 → 304
      Ndr; Ndr family

    10. NM_001360272.2 → NP_001347201.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS49486.1
      Conserved Domains (1) summary
      pfam03096
      Location:26 → 304
      Ndr; Ndr family

    11. NM_001360273.2 → NP_001347202.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS49486.1
      Conserved Domains (1) summary
      pfam03096
      Location:26 → 304
      Ndr; Ndr family

    12. NM_001360274.2 → NP_001347203.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS49486.1
      Conserved Domains (1) summary
      pfam03096
      Location:26 → 304
      Ndr; Ndr family

    13. NM_001360276.2 → NP_001347205.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS49486.1
      Conserved Domains (1) summary
      pfam03096
      Location:26 → 304
      Ndr; Ndr family

    14. NM_001424691.1 → NP_001411620.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087

    15. NM_001424692.1 → NP_001411621.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087

    16. NM_001424693.1 → NP_001411622.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087

    17. NM_001424694.1 → NP_001411623.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087

    18. NM_001424695.1 → NP_001411624.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0

    19. NM_001424696.1 → NP_001411625.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0

    20. NM_001424697.1 → NP_001411626.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0

    21. NM_001424698.1 → NP_001411627.1  protein NDRG2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC125087

    22. NM_001424699.1 → NP_001411628.1  protein NDRG2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC125087

    23. NM_001424700.1 → NP_001411629.1  protein NDRG2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC125087

    24. NM_001424701.1 → NP_001411630.1  protein NDRG2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC125087

    25. NM_013864.3 → NP_038892.1  protein NDRG2 isoform 1

      See identical proteins and their annotated locations for NP_038892.1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS27047.1
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Related
      ENSMUSP00000004673.8, ENSMUST00000004673.15
      Conserved Domains (1) summary
      pfam03096
      Location:40 → 318
      Ndr; Ndr family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      52142738..52151463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158660.1 → XP_036014553.1  protein NDRG2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Conserved Domains (1) summary
      pfam03096
      Location:40 → 318
      Ndr; Ndr family

    2. XM_036158662.1 → XP_036014555.1  protein NDRG2 isoform X2

      Conserved Domains (1) summary
      pfam03096
      Location:26 → 304
      Ndr; Ndr family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYG0.1 GenPept UniProtKB/Swiss-Prot:Q9QYG0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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