Mydgf myeloid derived growth factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mydgfprovided by MGI
Official Full Name: myeloid derived growth factorprovided by MGI
Primary source: MGI:MGI:2156020
See related: Ensembl:ENSMUSG00000019579 AllianceGenome:MGI:2156020
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il25; Ly6elg; D17Wsu104e
Summary: The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was identified in error as interleukin 25. This activity has not been reproducible, however, and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
Annotation information: Note: This gene was misidentified as IL25 due to the erroneous designation of AY038184.1 as belonging to SF20/IL25 in PMID 11714798. This paper, however, has since been retracted in PMID 12538725. [16 Aug 2013]
Expression: Ubiquitous expression in ovary adult (RPKM 88.8), large intestine adult (RPKM 83.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.2 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (56483541..56490920, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (56176541..56183920, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inflammatory Cell-Derived MYDGF Attenuates Endothelial LDL Transcytosis to Protect Against Atherogenesis.
Title: Inflammatory Cell-Derived MYDGF Attenuates Endothelial LDL Transcytosis to Protect Against Atherogenesis.
Myeloid-derived growth factor deficiency exacerbates mitotic catastrophe of podocytes in glomerular disease.
Title: Myeloid-derived growth factor deficiency exacerbates mitotic catastrophe of podocytes in glomerular disease.
Myeloid-derived growth factor inhibits inflammation and alleviates endothelial injury and atherosclerosis in mice.
Title: Myeloid-derived growth factor inhibits inflammation and alleviates endothelial injury and atherosclerosis in mice.
MYDGF attenuates podocyte injury and proteinuria by activating Akt/BAD signal pathway in mice with diabetic kidney disease.
Title: MYDGF attenuates podocyte injury and proteinuria by activating Akt/BAD signal pathway in mice with diabetic kidney disease.
Hypoxia-induced myeloid derived growth factor promotes hepatocellular carcinoma progression through remodeling tumor microenvironment.
Title: Hypoxia-induced myeloid derived growth factor promotes hepatocellular carcinoma progression through remodeling tumor microenvironment.
Mydgf promotes Cardiomyocyte proliferation and Neonatal Heart regeneration.
Title: Mydgf promotes Cardiomyocyte proliferation and Neonatal Heart regeneration.
maintains glucose homeostasis by inducing glucagon-like peptide-1 production and secretion
Title: Myeloid-Derived Growth Factor Promotes Intestinal Glucagon-Like Peptide-1 Production in Male Mice With Type 2 Diabetes.
The IL-25 made notable contributions to chronic HDM-induced allergic asthma pathology by facilitating clustering and cross-stimulation of different cell types in tissue.
Title: IL-25 Orchestrates Activation of Th Cells via Conventional Dendritic Cells in Tissue to Exacerbate Chronic House Dust Mite-Induced Asthma Pathology.
There were no significant differences in clinical scores and numbers of infiltrating eosinophils among IL-25KO, TSLPR KO, and wild-type mice.
Title: Roles of Epithelial Cell-Derived Type 2-Initiating Cytokines in Experimental Allergic Conjunctivitis.
Mydgf-deficient mice develop larger infarct scars and more severe contractile dysfunction compared to wild-type mice after experimental myocardial infarction.
Title: Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_4447-4448:966894303:1 (e-PCR)
- UniSTS:269387

D17Wsu104e (e-PCR), detects polymorphism
- UniSTS:142168

NoName (e-PCR)
- UniSTS:237671

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myeloid-derived growth factor

Names: UPF0556 protein C19orf10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.