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    Miip migration and invasion inhibitory protein [ Mus musculus (house mouse) ]

    Gene ID: 28010, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Miipprovided by MGI
    Official Full Name
    migration and invasion inhibitory proteinprovided by MGI
    Primary source
    MGI:MGI:106506
    See related
    Ensembl:ENSMUSG00000029022 AllianceGenome:MGI:106506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IIP45; D4Wsu114e
    Summary
    Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of cell migration. Is expressed in embryo. Orthologous to human MIIP (migration and invasion inhibitory protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 32.0), thymus adult (RPKM 28.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 E1; 4 78.56 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (147945235..147953176, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (147860778..147868719, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:147131061-147131362 Neighboring gene STARR-positive B cell enhancer mm9_chr4:147137358-147137659 Neighboring gene zinc finger protein 984 Neighboring gene STARR-positive B cell enhancer mm9_chr4:147149499-147149800 Neighboring gene STARR-positive B cell enhancer mm9_chr4:147153946-147154247 Neighboring gene STARR-positive B cell enhancer ABC_E4724 Neighboring gene STARR-positive B cell enhancer ABC_E9623 Neighboring gene STARR-positive B cell enhancer ABC_E6282 Neighboring gene STARR-seq mESC enhancer starr_12061 Neighboring gene STARR-positive B cell enhancer mm9_chr4:147185666-147185967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:147187429-147187616 Neighboring gene STARR-positive B cell enhancer mm9_chr4:147188614-147188915 Neighboring gene ribosomal protein S19, pseudogene 3 Neighboring gene zinc finger protein 933 Neighboring gene STARR-positive B cell enhancer ABC_E4726 Neighboring gene STARR-positive B cell enhancer ABC_E181 Neighboring gene Friend virus susceptibility 1 Neighboring gene mitofusin 2 Neighboring gene STARR-positive B cell enhancer ABC_E9625

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. Strong ER, et al. Genes (Basel), 2010 Dec 2. PMID 21779533, Free PMC Article
    2. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    migration and invasion-inhibitory protein
    Names
    invasion inhibitory protein 45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025365.2 → NP_001020536.2  migration and invasion-inhibitory protein isoform 2

      See identical proteins and their annotated locations for NP_001020536.2

      Status: VALIDATED

      Source sequence(s)
      CO039431, FJ618908
      Consensus CDS
      CCDS18923.2
      UniProtKB/Swiss-Prot
      A2A7Y5, Q3UZ92, Q8CFZ8, Q8VD71
      UniProtKB/TrEMBL
      C0KL25
      Related
      ENSMUSP00000030886.9, ENSMUST00000030886.15
      Conserved Domains (1) summary
      pfam15734
      Location:42 → 379
      MIIP; Migration and invasion-inhibitory

    2. NM_001374704.1 → NP_001361633.1  migration and invasion-inhibitory protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL607066
      Consensus CDS
      CCDS89855.1
      Conserved Domains (1) summary
      pfam15734
      Location:42 → 362
      MIIP; Migration and invasion-inhibitory

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      147945235..147953176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164176.1 → XP_036020069.1  migration and invasion-inhibitory protein isoform X2

      UniProtKB/Swiss-Prot
      A2A7Y5, Q3UZ92, Q8CFZ8, Q8VD71
      UniProtKB/TrEMBL
      C0KL25
      Conserved Domains (1) summary
      pfam15734
      Location:42 → 379
      MIIP; Migration and invasion-inhibitory

    2. XM_006538951.5 → XP_006539014.1  migration and invasion-inhibitory protein isoform X3

      Conserved Domains (1) summary
      pfam15734
      Location:1 → 310
      MIIP; Migration and invasion-inhibitory

    3. XM_036164177.1 → XP_036020070.1  migration and invasion-inhibitory protein isoform X4

      Conserved Domains (1) summary
      pfam15734
      Location:1 → 327
      MIIP; Migration and invasion-inhibitory

    4. XM_036164175.1 → XP_036020068.1  migration and invasion-inhibitory protein isoform X1

      Related
      ENSMUSP00000113897.3, ENSMUST00000119975.3
      Conserved Domains (1) summary
      pfam15734
      Location:42 → 362
      MIIP; Migration and invasion-inhibitory

    RNA

    1. XR_004941917.1 RNA Sequence

    2. XR_001784152.3 RNA Sequence

    3. XR_004941916.1 RNA Sequence

      Related
      ENSMUST00000156374.9

    4. XR_004941918.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_133873.2: Suppressed sequence

      Description
      NM_133873.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A7Y5.1 GenPept UniProtKB/Swiss-Prot:A2A7Y5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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