Brd7 bromodomain containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brd7provided by MGI
Official Full Name: bromodomain containing 7provided by MGI
Primary source: MGI:MGI:1349766
See related: Ensembl:ENSMUSG00000031660 AllianceGenome:MGI:1349766
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BP75; CELTIX1; Ptpn13ip
Summary: Enables transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of histone acetylation; and regulation of transcription, DNA-templated. Predicted to act upstream of or within Wnt signaling pathway. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; lung; retina; and tooth. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human BRD7 (bromodomain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 13.7), CNS E14 (RPKM 11.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 43.07 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (89056522..89089249, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (88329894..88362252, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRD7 improves glucose homeostasis independent of IRS proteins.
Title: BRD7 improves glucose homeostasis independent of IRS proteins.
A novel basis for understanding the molecular dynamics of glucose metabolism and the unique function of BRD7 in the regulation of glucose homeostasis.
Title: BRD7 regulates the insulin-signaling pathway by increasing phosphorylation of GSK3β.
these findings suggest that BRD7 has an anti-inflammatory role during early acute inflammation by inhibiting activation of the NF-small ka, CyrillicB signaling pathway, which provides evidence to aid in understanding the therapeutic effects of BRD7 on inflammatory diseases
Title: BRD7 plays an anti-inflammatory role during early acute inflammation by inhibiting activation of the NF-кB signaling pathway.
Furthermore, Brd7 inhibition alters the phenotype of macrophages and promotes plaque instability, at least partly via STAT6 signaling. Our data define a previously undescribed role of Brd7 in the development of atherosclerosis.
Title: Bromodomain-containing protein 7 deficiency augments atherosclerotic lesions in ApoE(-/-) mice.
Homozygous BRD7 knockout (KO) mice showed retardation in development.
Title: The role of BRD7 in embryo development and glucose metabolism.
Homozygous knockout of BRD7 (BRD7(-/-)) resulted in complete male infertility and spermatogenesis defects, including deformed acrosomal formation, degenerative elongating spermatids and irregular head morphology in postmeiotic germ cells in the seminiferous epithelium, which led to the complete arrest of spermatogenesis at step 13.
Title: Knockout of BRD7 results in impaired spermatogenesis and male infertility.
Results link BRD7 to medial prefrontal cortex synaptic plasticity regulation; knockout leads to impaired cognitive behavior accompanied by reduced synaptic related proteins expression and dendritic spines or branching in the medial prefrontal cortex
Title: Inactivation of BRD7 results in impaired cognitive behavior and reduced synaptic plasticity of the medial prefrontal cortex.
BRD7 interacts with the regulatory subunits of phosphatidylinositol 3-kinase (PI3K) and increases the nuclear translocation of both p85alpha and p85beta and the spliced form of XBP1 (XBP1s).
Title: BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K.
TRIM24 regulates AR-mediated transcription in collaboration with TIP60 and BRD7.
Title: TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells.
BRD7 is a novel PBAF-specific SWI/SNF subunit that is required for target gene activation and repression in embryonic stem cells
Title: BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone binding	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of myoblast differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G0 to G1 transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic metaphase/anaphase transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of nucleotide-excision repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RSC-type complex	NAS Non-traceable Author Statement more info	PubMed
part_of SWI/SNF superfamily-type complex	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	NAS Non-traceable Author Statement more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in kinetochore	NAS Non-traceable Author Statement more info	PubMed
located_in nuclear matrix	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: bromodomain-containing protein 7

Names: 75 kDa bromodomain protein; bromodomain protein 75 kDa; protein tyrosine phosphatase, non-receptor type 13 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001377013.1 → NP_001363942.1 bromodomain-containing protein 7 isoform 2

Status: VALIDATED

Description

Transcript Variant: Variants 2 and 6 encode the same isoform (2).

Source sequence(s)

AC155170

UniProtKB/TrEMBL

A0AA74KT86

Conserved Domains (2) summary

cd05513
Location:135 → 232

Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

pfam12024
Location:287 → 533

DUF3512; Domain of unknown function (DUF3512)
NM_001377014.1 → NP_001363943.1 bromodomain-containing protein 7 isoform 3

Status: VALIDATED

Source sequence(s)

AC155170

UniProtKB/TrEMBL

A0AA74KT86

Conserved Domains (2) summary

cd05513
Location:135 → 232

Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

pfam12024
Location:287 → 532

DUF3512; Domain of unknown function (DUF3512)
NM_001377015.1 → NP_001363944.1 bromodomain-containing protein 7 isoform 4

Status: VALIDATED

Source sequence(s)

AC155170

UniProtKB/TrEMBL

A0AA74KT86

Conserved Domains (2) summary

cd05513
Location:135 → 232

Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

pfam12024
Location:287 → 533

DUF3512; Domain of unknown function (DUF3512)
NM_001377016.1 → NP_001363945.1 bromodomain-containing protein 7 isoform 1

Status: VALIDATED

Description

Transcript Variant: Variants 1 and 5 encode the same isoform (1).

Source sequence(s)

AC155170

UniProtKB/Swiss-Prot

O88665, Q3UQ56, Q3UU06, Q9CT78

UniProtKB/TrEMBL

A0AA74KT86

Conserved Domains (2) summary

cd05513
Location:135 → 232

Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

pfam12024
Location:287 → 532

DUF3512; Domain of unknown function (DUF3512)
NM_001377017.1 → NP_001363946.1 bromodomain-containing protein 7 isoform 2

Status: VALIDATED

Description

Transcript Variant: Variants 2 and 6 encode the same isoform (2).

Source sequence(s)

AC155170

UniProtKB/TrEMBL

A0AA74KT86

Conserved Domains (2) summary

cd05513
Location:135 → 232

Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

pfam12024
Location:287 → 533

DUF3512; Domain of unknown function (DUF3512)
NM_012047.3 → NP_036177.1 bromodomain-containing protein 7 isoform 1

See identical proteins and their annotated locations for NP_036177.1

Status: VALIDATED

Description

Transcript Variant: Variants 1 and 5 encode the same isoform (1).

Source sequence(s)

AC155170

Consensus CDS

CCDS22510.1

UniProtKB/Swiss-Prot

O88665, Q3UQ56, Q3UU06, Q9CT78

UniProtKB/TrEMBL

A0AA74KT86

Related

ENSMUSP00000034085.8, ENSMUST00000034085.8

Conserved Domains (2) summary

cd05513
Location:135 → 232

Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

pfam12024
Location:287 → 532

DUF3512; Domain of unknown function (DUF3512)