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    Gprin1 G protein-regulated inducer of neurite outgrowth 1 [ Mus musculus (house mouse) ]

    Gene ID: 26913, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gprin1provided by MGI
    Official Full Name
    G protein-regulated inducer of neurite outgrowth 1provided by MGI
    Primary source
    MGI:MGI:1349455
    See related
    Ensembl:ENSMUSG00000069227 AllianceGenome:MGI:1349455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Z16; GRIN1
    Summary
    Enables phosphoprotein binding activity. Acts upstream of or within neuron projection development. Located in plasma membrane. Is expressed in several structures, including axial skeleton; bone; central nervous system; peripheral nervous system ganglion; and sensory organ. Orthologous to human GPRIN1 (G protein regulated inducer of neurite outgrowth 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 30.4), whole brain E14.5 (RPKM 27.4) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gprin1 in Genome Data Viewer
    Location:
    13 B1; 13 29.18 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54884484..54897486, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54736671..54749874, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54788483-54788694 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54789238-54789421 Neighboring gene STARR-positive B cell enhancer ABC_E2408 Neighboring gene ring finger protein 44 Neighboring gene STARR-positive B cell enhancer ABC_E3083 Neighboring gene cadherin-related family member 2 Neighboring gene synuclein, beta Neighboring gene STARR-seq mESC enhancer starr_34592 Neighboring gene predicted gene 16249

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia. Labrie V, et al. Psychopharmacology (Berl), 2008 Oct. PMID 18597079
    2. Dynamic expression patterns of G protein-regulated inducer of neurite outgrowth 1 (GRIN1) and its colocalization with Galphao implicate significant roles of Galphao-GRIN1 signaling in nervous system. Masuho I, et al. Dev Dyn, 2008 Sep. PMID 18729205, Free PMC Article
    3. Functional characterization of Galphao signaling through G protein-regulated inducer of neurite outgrowth 1. Nakata H, et al. Mol Pharmacol, 2005 Mar. PMID 15585744
    4. A candidate target for G protein action in brain. Chen LT, et al. J Biol Chem, 1999 Sep 17. PMID 10480904
    5. Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry. Del Mar Masdeu M, et al. Oncotarget, 2017 Nov 24. PMID 29254152, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. responses to social novelty and nonspatial change remained unaffected, indicating that the Grin1(D481N) mutation induces selective deficits in sociability and spatial discrimination, while leaving intact the ability to react to novelty.
      Title: Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia.
    2. Data show that GRIN1 expression was limited to the nervous system at all developmental stages tested. GRIN1 colocalized with Galphao at neuronal dendrites and axons, but it was not detected in glial cells.
      Title: Dynamic expression patterns of G protein-regulated inducer of neurite outgrowth 1 (GRIN1) and its colocalization with Galphao implicate significant roles of Galphao-GRIN1 signaling in nervous system.
    3. Binding of activated Galphao to GRIN1 induces activation of Cdc42, which leads to morphological changes in neuronal cells.
      Title: Functional characterization of Galphao signaling through G protein-regulated inducer of neurite outgrowth 1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphoprotein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    G protein-regulated inducer of neurite outgrowth 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316710.2 → NP_001303639.1  G protein-regulated inducer of neurite outgrowth 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC162526
      Consensus CDS
      CCDS26534.1
      UniProtKB/Swiss-Prot
      Q3UNH4, Q6PGF9, Q9QZY2
      Related
      ENSMUSP00000115539.2, ENSMUST00000135343.2
      Conserved Domains (1) summary
      pfam15235
      Location:791 → 929
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    2. NM_012014.5 → NP_036144.2  G protein-regulated inducer of neurite outgrowth 1

      See identical proteins and their annotated locations for NP_036144.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein
      Source sequence(s)
      AC162526
      Consensus CDS
      CCDS26534.1
      UniProtKB/Swiss-Prot
      Q3UNH4, Q6PGF9, Q9QZY2
      Related
      ENSMUSP00000097106.2, ENSMUST00000099506.2
      Conserved Domains (1) summary
      pfam15235
      Location:791 → 929
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      54884484..54897486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UNH4.2 GenPept UniProtKB/Swiss-Prot:Q3UNH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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