Cops5 COP9 signalosome subunit 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cops5provided by MGI
Official Full Name: COP9 signalosome subunit 5provided by MGI
Primary source: MGI:MGI:1349415
See related: Ensembl:ENSMUSG00000025917 AllianceGenome:MGI:1349415
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CSN5; Jab1; Sgn5; Mov34
Summary: Enables enzyme binding activity and macrophage migration inhibitory factor binding activity. Acts upstream of or within regulation of cell cycle. Part of COP9 signalosome. Is expressed in several structures, including 1st branchial arch; central nervous system; cranium; genitourinary system; and sensory organ. Orthologous to human COPS5 (COP9 signalosome subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 37.8), placenta adult (RPKM 35.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A2; 1 2.29 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (10094825..10108384, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (10024600..10038159, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inactivation of Cops5 in Smooth Muscle Cells Causes Abnormal Reproductive Hormone Homeostasis and Development in Mice.
Title: Inactivation of Cops5 in Smooth Muscle Cells Causes Abnormal Reproductive Hormone Homeostasis and Development in Mice.
JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice.
Title: JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice.
The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated mouse chondrocyte differentiation by repressing p53 activity.
Title: The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated mouse chondrocyte differentiation by repressing p53 activity.
COP9 signalosome complex subunit 5, an IFT20 binding partner, is essential to maintain male germ cell survival and acrosome biogenesisdagger.
Title: COP9 signalosome complex subunit 5, an IFT20 binding partner, is essential to maintain male germ cell survival and acrosome biogenesis†.
Cops5 KO leads to decreased expression of the pluripotency marker Nanog, proliferation defect, G2/M cell-cycle arrest and apoptosis.
Title: Cops5 safeguards genomic stability of embryonic stem cells through regulating cellular metabolism and DNA repair.
these findings suggested that strategies based on activation of CSN5/LKB1 axis might be promising in the treatment of hypertrophic cardiomyopathy
Title: CSN5 attenuates Ang II-induced cardiac hypertrophy through stabilizing LKB1.
Asrij sequesters CSN5 via its conserved OCIA domain, thereby preventing p53 degradation.
Title: Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence.
Genetic deletion of Csn5 in Apoe(-/-) mice markedly exacerbated atherosclerotic lesion formation.
Title: Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo.
CSN3 and CSN5 are involved in oocyte meiosis by regulating degradation of Cyclin B1 and Securin via APC/C.
Title: Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation.
COPS5 overexpression reduced spinophilin in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills
Title: COPS5 protein overexpression increases amyloid plaque burden, decreases spinophilin-immunoreactive puncta, and exacerbates learning and memory deficits in the mouse brain.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cops5 (e-PCR), detects polymorphism
- UniSTS:479082

AI303502 (e-PCR)
- UniSTS:178359

RH126505 (e-PCR)
- UniSTS:209652

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables deNEDDylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables macrophage migration inhibitory factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metal-dependent deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in exosomal secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein deneddylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein deneddylation	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of IRE1-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info
part_of COP9 signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: COP9 signalosome complex subunit 5

Names: COP9 (constitutive photomorphogenic) homolog, subunit 5; COP9 complex S5; Jun activation domain-binding protein 1; Jun coactivator; Kip1 C-terminus-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277101.1 → NP_001264030.1 COP9 signalosome complex subunit 5 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC102570, AK005728, BC046753, BY393956

UniProtKB/Swiss-Prot

O35864

Conserved Domains (1) summary

cd08069
Location:33 → 297

MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5
NM_013715.2 → NP_038743.1 COP9 signalosome complex subunit 5 isoform 1

See identical proteins and their annotated locations for NP_038743.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC102570, AK005728, AK012499, BY393956, CX240457

Consensus CDS

CCDS14818.1

UniProtKB/Swiss-Prot

O35864, Q3UA70, Q8C1S1

Related

ENSMUSP00000027050.4, ENSMUST00000027050.10

Conserved Domains (1) summary

cd08069
Location:44 → 314

MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

RNA

NR_102282.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC102570, AK005728, BC046753, BY393956, DV056728