Cops3 COP9 signalosome subunit 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cops3provided by MGI
Official Full Name: COP9 signalosome subunit 3provided by MGI
Primary source: MGI:MGI:1349409
See related: Ensembl:ENSMUSG00000019373 AllianceGenome:MGI:1349409
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Csn3; Sgn3
Summary: Acts upstream of or within in utero embryonic development. Part of COP9 signalosome. Is expressed in several structures, including inner cell mass; reproductive system; skeletal muscle tissue; spleen; and urinary system. Orthologous to human COPS3 (COP9 signalosome subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 11.5), CNS E14 (RPKM 9.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 37.8 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (59708621..59739080, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (59817795..59848245, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma.
Title: The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma.
COPS3 AS lncRNA enhances myogenic differentiation and maintains fast-type myotube phenotype.
Title: COPS3 AS lncRNA enhances myogenic differentiation and maintains fast-type myotube phenotype.
The COP9 signalosome subunit 3 is necessary for early embryo survival by way of a stable protein deposit in mouse oocytes.
Title: The COP9 signalosome subunit 3 is necessary for early embryo survival by way of a stable protein deposit in mouse oocytes.
This is the first study toward understanding the role of the CSN3 in skeletal muscle differentiation and proliferation. Our results show that knockdown of CSN3 in C2C12 cells leads to impaired differentiation, proliferation and cell cycle regulation of myoblasts.
Title: Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathway.
CSN3 and CSN5 are involved in oocyte meiosis by regulating degradation of Cyclin B1 and Securin via APC/C.
Title: Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation.
Cops3 encodes the third subunit of the COP9 signalosome, which controls a wide vasriety of molecules of different functions.
Title: COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124371 (e-PCR)
- UniSTS:161193

RH137040 (e-PCR)
- UniSTS:219129

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deneddylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info
part_of COP9 signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: COP9 signalosome complex subunit 3

Names: COP9 (constitutive photomorphogenic) homolog, subunit 3; COP9 (constitutive photomorphogenic), subunit 3; COP9 complex S3; JAB1-containing signalosome subunit 3; signalosome subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417566.1 → NP_001404495.1 COP9 signalosome complex subunit 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC068808
NM_011991.2 → NP_036121.1 COP9 signalosome complex subunit 3 isoform 1

See identical proteins and their annotated locations for NP_036121.1

Status: VALIDATED

Source sequence(s)

AC068808

Consensus CDS

CCDS24778.1

UniProtKB/Swiss-Prot

O88543

UniProtKB/TrEMBL

Q3UQL2

Related

ENSMUSP00000019517.4, ENSMUST00000019517.10

Conserved Domains (1) summary

pfam01399
Location:259 → 362

PCI; PCI domain

RNA

NR_184531.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC068808
NR_184532.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC068808
NR_184533.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC068808
NR_184534.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC068808
NR_184535.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC068808

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

59708621..59739080 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246025.1 → XP_030101885.1 COP9 signalosome complex subunit 3 isoform X1

Conserved Domains (1) summary

pfam01399
Location:239 → 342

PCI; PCI domain
XM_036156712.1 → XP_036012605.1 COP9 signalosome complex subunit 3 isoform X1

Conserved Domains (1) summary

pfam01399
Location:239 → 342

PCI; PCI domain