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    Psg18 pregnancy specific beta-1-glycoprotein 18 [ Mus musculus (house mouse) ]

    Gene ID: 26438, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Psg18provided by MGI
    Official Full Name
    pregnancy specific beta-1-glycoprotein 18provided by MGI
    Primary source
    MGI:MGI:1347251
    See related
    Ensembl:ENSMUSG00000003505 AllianceGenome:MGI:1347251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cea3; Cea-3; mmCGM6
    Summary
    Acts upstream of or within positive regulation of gene expression and regulation of interleukin-10 production. Is expressed in decidua; placenta; and primary trophoblast giant cell. Orthologous to human CEACAM4 (CEA cell adhesion molecule 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 90.8) See more
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    Genomic context

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    Location:
    7 A2; 7 9.15 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18079669..18088963, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18345744..18355038, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene MHC I like leukocyte 1 Neighboring gene STARR-seq mESC enhancer starr_18167 Neighboring gene STARR-seq mESC enhancer starr_18168 Neighboring gene myotubularin related protein 2 pseudogene Neighboring gene pregnancy-specific beta-1-glycoprotein 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Psg18 is specifically expressed in follicle-associated epithelium. Kawano K, et al. Cell Struct Funct, 2007. PMID 17984568
    2. Regulation of programmed cell death by basement membranes in embryonic development. Murray P, et al. J Cell Biol, 2000 Sep 4. PMID 10974008, Free PMC Article
    3. Murine CD9 is the receptor for pregnancy-specific glycoprotein 17. Waterhouse R, et al. J Exp Med, 2002 Jan 21. PMID 11805154, Free PMC Article
    4. Coordinate expression of splice variants of the murine pregnancy-specific glycoprotein (PSG) gene family during placental development. Kromer B, et al. Eur J Biochem, 1996 Dec 1. PMID 8973644
    5. Pregnancy specific glycoprotein 18 induces IL-10 expression in murine macrophages. Wessells J, et al. Eur J Immunol, 2000 Jul. PMID 10940872

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinin biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of interleukin-10 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pregnancy specific glycoprotein 18
    Names
    carcinoembryonic antigen 3
    pregnancy specific glycoprotein 18; carcinoembryonic antigen 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163685.1 → NP_001157157.1  pregnancy specific glycoprotein 18 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame internal exon and the 3' exon, but has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) lacks an internal segment and has a different and much shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK167661, BQ031876, CN704107
      Consensus CDS
      CCDS52050.1
      UniProtKB/TrEMBL
      E9Q8L0, Q3TIY4
      Related
      ENSMUSP00000096380.4, ENSMUST00000098783.5
      Conserved Domains (2) summary
      cd05774
      Location:156 → 258
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:160 → 258
      IG_like; Immunoglobulin like

    2. NM_011963.2 → NP_036093.2  pregnancy specific glycoprotein 18 isoform 1

      See identical proteins and their annotated locations for NP_036093.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC138857, BY713630
      Consensus CDS
      CCDS20869.1
      UniProtKB/TrEMBL
      B2RSG7, Q9R038
      Related
      ENSMUSP00000003597.8, ENSMUST00000003597.15
      Conserved Domains (3) summary
      cd05774
      Location:277 → 379
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00408
      Location:401 → 462
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:396 → 473
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      18079669..18088963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540003.4 → XP_006540066.1  pregnancy specific glycoprotein 18 isoform X1

      UniProtKB/TrEMBL
      Q9R038
      Conserved Domains (3) summary
      smart00408
      Location:329 → 390
      IGc2; Immunoglobulin C-2 Type
      cd05774
      Location:157 → 261
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:277 → 310
      Ig; Immunoglobulin domain

    2. XM_006540006.4 → XP_006540069.1  pregnancy specific glycoprotein 18 isoform X2

      Conserved Domains (2) summary
      smart00408
      Location:280 → 341
      IGc2; Immunoglobulin C-2 Type
      cd05774
      Location:156 → 260
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    Nucleotide Protein Strain
    Heading Accession and Version

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