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    Adgre5 adhesion G protein-coupled receptor E5 [ Mus musculus (house mouse) ]

    Gene ID: 26364, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Adgre5provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor E5provided by MGI
    Primary source
    MGI:MGI:1347095
    See related
    Ensembl:ENSMUSG00000002885 AllianceGenome:MGI:1347095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd97; TM7LN1
    Summary
    Predicted to enable G protein-coupled receptor activity and chondroitin sulfate binding activity. Acts upstream of or within positive regulation of synapse assembly. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in vibratory urticaria. Orthologous to several human genes including ADGRE5 (adhesion G protein-coupled receptor E5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 217.2), spleen adult (RPKM 95.9) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C2; 8 40.22 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84449874..84467812, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83723245..83741311, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1372 Neighboring gene GIPC PDZ domain containing family, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E11744 Neighboring gene prostaglandin E receptor 1 (subtype EP1) Neighboring gene protein kinase N1 Neighboring gene STARR-positive B cell enhancer ABC_E9319 Neighboring gene STARR-seq mESC enhancer starr_22095 Neighboring gene STARR-positive B cell enhancer ABC_E562 Neighboring gene DEAD box helicase 39a Neighboring gene microRNA 1668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86260655-86260859 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86263836-86264037 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86271935-86272044 Neighboring gene predicted gene, 46046 Neighboring gene STARR-positive B cell enhancer ABC_E10 Neighboring gene predicted gene, 42030

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD. Cerny O, et al. PLoS Pathog, 2021 Jul. PMID 34314469, Free PMC Article
    2. Contradictory Role of CD97 in Basal and Tumor Necrosis Factor-Induced Osteoclastogenesis In Vivo. Yeon Won H, et al. Arthritis Rheumatol, 2016 May. PMID 26663852, Free PMC Article
    3. Mice overexpressing CD97 in intestinal epithelial cells provide a unique model for mammalian postnatal intestinal cylindrical growth. Aust G, et al. Mol Biol Cell, 2013 Jul. PMID 23676664, Free PMC Article
    4. Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions. Becker S, et al. PLoS One, 2010 Jan 13. PMID 20084281, Free PMC Article
    5. Therapeutic antibody targeting of CD97 in experimental arthritis: the role of antigen expression, shedding, and internalization on the pharmacokinetics of anti-CD97 monoclonal antibody 1B2. de Groot DM, et al. J Immunol, 2009 Sep 15. PMID 19717518

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation.
      Title: CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation.
    2. CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.
      Title: CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.
    3. CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.
      Title: CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.
    4. How to Obtain a Mega-Intestine with Normal Morphology: In Silico Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse.
      Title: How to Obtain a Mega-Intestine with Normal Morphology: In Silico Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse.
    5. These findings demonstrate that CD97 is a positive regulator of osteoclast-like cell differentiation, a mechanism that influences bone homeostasis. However, the presence of CD97 may be essential to suppress the initial osteoclastogenesis that occurs in response to acute and local inflammatory stimuli.
      Title: Contradictory Role of CD97 in Basal and Tumor Necrosis Factor-Induced Osteoclastogenesis In Vivo.
    6. We conclude that CD97 is located in the SR and at the peripheral sarcolemma of human and murine skeletal muscle, where its absence affects the structure of the SR without impairing skeletal muscle function
      Title: Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function.
    7. Intestinal enlargement by CD97 requires its seven-span transmembrane/cytoplasmic C-terminal fragment.
      Title: Mice overexpressing CD97 in intestinal epithelial cells provide a unique model for mammalian postnatal intestinal cylindrical growth.
    8. CD55 downregulates CD97 surface expression on circulating leukocytes by a process that requires physical forces.
      Title: Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55.
    9. Insight into a role for CD55 interaction with CD97 in the pathogenesis of rheumatoid arthritis suggest that therapeutic strategies that disrupt CD55/CD97 may be clinically beneficial.
      Title: Deletion of either CD55 or CD97 ameliorates arthritis in mouse models.
    10. Despite the broad expression pattern of wild-type murine CD97, the successfully deleted gene Cd97-deficient mouse that is created has no overt phenotype, except for a mild granulocytosis that is normal in the absence of CD97.
      Title: Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chondroitin sulfate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in leading edge membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor E5
    Names
    CD97 antigen
    EGF-TM7 receptor
    leukocyte antigen CD97

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163029.2 → NP_001156501.1  adhesion G protein-coupled receptor E5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001156501.1

      Status: VALIDATED

      Source sequence(s)
      AC164432
      Consensus CDS
      CCDS52610.1
      UniProtKB/TrEMBL
      A0A0D9SEG8, Q4FJS6
      Related
      ENSMUSP00000002964.8, ENSMUST00000002964.14
      Conserved Domains (3) summary
      pfam00002
      Location:432 → 672
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam01825
      Location:386 → 424
      GPS; GPCR proteolysis site, GPS, motif
      pfam07645
      Location:120 → 154
      EGF_CA; Calcium-binding EGF domain

    2. NM_001163030.2 → NP_001156502.1  adhesion G protein-coupled receptor E5 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164432
      Consensus CDS
      CCDS52611.1
      UniProtKB/Swiss-Prot
      Q923A1, Q9CVI5, Q9JLQ8, Q9Z0M6
      UniProtKB/TrEMBL
      E9QMJ5
      Related
      ENSMUSP00000105427.3, ENSMUST00000109802.3
      Conserved Domains (3) summary
      pfam00002
      Location:481 → 721
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam01825
      Location:435 → 473
      GPS; GPCR proteolysis site, GPS, motif
      pfam07645
      Location:120 → 167
      EGF_CA; Calcium-binding EGF domain

    3. NM_001163031.2 → NP_001156503.1  adhesion G protein-coupled receptor E5 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001156503.1

      Status: VALIDATED

      Source sequence(s)
      AC164432
      Consensus CDS
      CCDS52612.1
      UniProtKB/TrEMBL
      Q4FJS6, Q9DC42
      Related
      ENSMUSP00000128220.2, ENSMUST00000166939.8
      Conserved Domains (3) summary
      pfam00002
      Location:430 → 670
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam01825
      Location:384 → 422
      GPS; GPCR proteolysis site, GPS, motif
      pfam07645
      Location:118 → 152
      EGF_CA; Calcium-binding EGF domain

    4. NM_001414296.1 → NP_001401225.1  adhesion G protein-coupled receptor E5 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164432

    5. NM_001414297.1 → NP_001401226.1  adhesion G protein-coupled receptor E5 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164432

    6. NM_001414298.1 → NP_001401227.1  adhesion G protein-coupled receptor E5 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164432

    7. NM_001414300.1 → NP_001401229.1  adhesion G protein-coupled receptor E5 isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164432

    8. NM_001414301.1 → NP_001401230.1  adhesion G protein-coupled receptor E5 isoform 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164432

    9. NM_001414302.1 → NP_001401231.1  adhesion G protein-coupled receptor E5 isoform 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164432

    10. NM_011925.3 → NP_036055.2  adhesion G protein-coupled receptor E5 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164432
      Consensus CDS
      CCDS22461.1
      UniProtKB/Swiss-Prot
      Q923A1, Q9CVI5, Q9JLQ8, Q9Z0M6
      UniProtKB/TrEMBL
      E9QJS7
      Related
      ENSMUSP00000075240.7, ENSMUST00000075843.13
      Conserved Domains (3) summary
      pfam00002
      Location:526 → 766
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam01825
      Location:480 → 518
      GPS; GPCR proteolysis site, GPS, motif
      pfam07645
      Location:165 → 212
      EGF_CA; Calcium-binding EGF domain

    RNA

    1. NR_183247.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164432

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84449874..84467812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0M6.2 GenPept UniProtKB/Swiss-Prot:Q9Z0M6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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