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    Zfp53 zinc finger protein 53 [ Mus musculus (house mouse) ]

    Gene ID: 24132, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp53provided by MGI
    Official Full Name
    zinc finger protein 53provided by MGI
    Primary source
    MGI:MGI:99200
    See related
    Ensembl:ENSMUSG00000057409 AllianceGenome:MGI:99200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KRAZ1; zfas8; Zfp-53; Zfp118; D030067O06Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body and nucleolus. Predicted to be active in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF300 (zinc finger protein 300). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 1.7), CNS E18 (RPKM 1.1) and 27 other tissues See more
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    Genomic context

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    See Zfp53 in Genome Data Viewer
    Location:
    17 A3.2; 17 11.4 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (21709179..21742899)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (21488934..21533201)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8655 Neighboring gene zinc finger protein 51 Neighboring gene STARR-seq mESC enhancer starr_42008 Neighboring gene STARR-seq mESC enhancer starr_42009 Neighboring gene predicted gene, 52290 Neighboring gene STARR-positive B cell enhancer ABC_E3186 Neighboring gene RIKEN cDNA 9330136K24 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:21669090-21669243 Neighboring gene zinc finger protein 52 Neighboring gene STARR-positive B cell enhancer ABC_E9942 Neighboring gene zinc finger protein 948

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Two novel Krüppel-associated box-containing zinc-finger proteins, KRAZ1 and KRAZ2, repress transcription through functional interaction with the corepressor KAP-1 (TIF1beta/KRIP-1). Agata Y, et al. J Biol Chem, 1999 Jun 4. PMID 10347202
    2. A cluster of related zinc finger protein genes is deleted in the mouse embryonic lethal mutation tw18. Crossley PH, et al. Proc Natl Acad Sci U S A, 1991 Sep 15. PMID 1680234, Free PMC Article
    3. Physical analysis of the region deleted in the tw18 allele of the mouse tcl-4 complementation group. Barclay J, et al. Genomics, 1996 Aug 15. PMID 8812414
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 53
    Names
    Zinc finger protein 118

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013843.3 → NP_038871.1  zinc finger protein 53

      See identical proteins and their annotated locations for NP_038871.1

      Status: VALIDATED

      Source sequence(s)
      AK030965, BY741862, CT010433
      Consensus CDS
      CCDS28440.1
      UniProtKB/TrEMBL
      Q9Z117
      Related
      ENSMUSP00000156751.2, ENSMUST00000233158.2
      Conserved Domains (3) summary
      COG5048
      Location:223 → 627
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:508 → 528
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:53 → 93
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      21709179..21742899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160610.1 → XP_036016503.1  zinc finger protein 53 isoform X1

      UniProtKB/TrEMBL
      Q9Z117
      Conserved Domains (3) summary
      COG5048
      Location:223 → 627
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:508 → 528
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:53 → 93
      KRAB; KRAB box

    2. XM_030249806.2 → XP_030105666.1  zinc finger protein 53 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:182 → 586
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:467 → 487
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box

    3. XM_030249807.2 → XP_030105667.1  zinc finger protein 53 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:141 → 545
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:426 → 446
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_036160611.1 → XP_036016504.1  zinc finger protein 53 isoform X4

      Conserved Domains (2) summary
      COG5048
      Location:103 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:388 → 408
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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