Ubd ubiquitin D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ubdprovided by MGI
Official Full Name: ubiquitin Dprovided by MGI
Primary source: MGI:MGI:1344410
See related: Ensembl:ENSMUSG00000035186 AllianceGenome:MGI:1344410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FAT10
Summary: Predicted to enable proteasome binding activity. Involved in cellular protein metabolic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of apoptotic process. Acts upstream of or within response to interferon-gamma and response to tumor necrosis factor. Located in cytoplasm and nucleus. Is expressed in alimentary system; aorta; male reproductive gland or organ; olfactory lobe; and thymus. Orthologous to human UBD (ubiquitin D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 9.7), large intestine adult (RPKM 5.6) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 19.16 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (37504783..37506992)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (37193892..37196101)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARalpha.
Title: The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARα.
FAT10 and NUB1L cooperate to activate the 26S proteasome.
Title: FAT10 and NUB1L cooperate to activate the 26S proteasome.
Evaluating the role of Ubiquitin D gene expression in types of leukemia.
Title: Evaluating the role of Ubiquitin D gene expression in types of leukemia.
Ubiquitin like protein FAT10 repressed cardiac fibrosis after myocardial ischemic via mediating degradation of Smad3 dependent on FAT10-proteasome system.
Title: Ubiquitin like protein FAT10 repressed cardiac fibrosis after myocardial ischemic via mediating degradation of Smad3 dependent on FAT10-proteasome system.
Ubiquitin-like protein FAT10 promotes renal fibrosis by stabilizing USP7 to prolong CHK1-mediated G2/M arrest in renal tubular epithelial cells.
Title: Ubiquitin-like protein FAT10 promotes renal fibrosis by stabilizing USP7 to prolong CHK1-mediated G2/M arrest in renal tubular epithelial cells.
Ubiquitin D Promotes Progression of Oral Squamous Cell Carcinoma via NF-Kappa B Signaling.
Title: Ubiquitin D Promotes Progression of Oral Squamous Cell Carcinoma via NF-Kappa B Signaling.
FAT10 protects against ischemia-induced ventricular arrhythmia by decreasing Nedd4-2/Nav1.5 complex formation.
Title: FAT10 protects against ischemia-induced ventricular arrhythmia by decreasing Nedd4-2/Nav1.5 complex formation.
potentiates the TNFalpha/TNFR1 signaling pathway to induce FAT10 expression in mouse macrophages.
Title: IFNγ potentiates TNFα/TNFR1 signaling to induce FAT10 expression in macrophages.
these findings revealed a novel role of FAT10 in protection against ischemia-induced injury via stabilization of Cav-3
Title: FAT10 attenuates hypoxia-induced cardiomyocyte apoptosis by stabilizing caveolin-3.
FAT10 fine-tunes the balance of interferons during viral infection by lowering the production of type I and enhancing type II interferons.
Title: The ubiquitin-like modifier FAT10 is required for normal IFN-γ production by activated CD8(+) T cells.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

52S (e-PCR), detects polymorphism
- UniSTS:140964

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in aggresome assembly	ISO Inferred from Sequence Orthology more info
involved_in myeloid dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein modification by small protein conjugation	IC Inferred by Curator more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle phase transition	ISO Inferred from Sequence Orthology more info
involved_in response to tumor necrosis factor	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin D

Names: Diubiquitin; ubiquitin-like protein FAT10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.