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    Tpra1 transmembrane protein, adipocyte asscociated 1 [ Mus musculus (house mouse) ]

    Gene ID: 24100, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tpra1provided by MGI
    Official Full Name
    transmembrane protein, adipocyte asscociated 1provided by MGI
    Primary source
    MGI:MGI:1345190
    See related
    Ensembl:ENSMUSG00000002871 AllianceGenome:MGI:1345190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    40kDa; Gpr175; Tpra40
    Summary
    Predicted to enable G protein-coupled receptor activity. Acts upstream of or within embryonic cleavage and negative regulation of mitotic cell cycle phase transition. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in brain. Orthologous to human TPRA1 (transmembrane protein adipocyte associated 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 50.6), ovary adult (RPKM 24.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 D1; 6 39.65 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88879238..88889216)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88902251..88912240)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15612 Neighboring gene podocalyxin-like 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88836578-88836779 Neighboring gene minichromosome maintenance complex component 2 Neighboring gene STARR-positive B cell enhancer ABC_E2794 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88852049-88852232 Neighboring gene predicted gene, 36268 Neighboring gene STARR-positive B cell enhancer ABC_E2795 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88889573-88889760 Neighboring gene predicted gene, 53294

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice. Yang H, et al. Endocrinology, 1999 Jun. PMID 10342878
    2. TPRA40/GPR175 regulates early mouse embryogenesis through functional membrane transport by Sjögren's syndrome-associated protein NA14. Aki T, et al. J Cell Physiol, 2008 Oct. PMID 18459117
    3. Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. van der Zwaag B, et al. Genomics, 2005 Jul. PMID 15953540
    4. Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains. Vadasz C, et al. Neurochem Res, 2007 Jul. PMID 17273929, Free PMC Article
    5. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the functional plasma membrane transport of TPRA40 that regulates cell division of mouse embryos is mediated by NA14.
      Title: TPRA40/GPR175 regulates early mouse embryogenesis through functional membrane transport by Sjögren's syndrome-associated protein NA14.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within embryonic cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of mitotic cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein adipocyte-associated 1
    Names
    G protein-coupled receptor 175
    integral membrane protein GPR175
    transmembrane domain protein of 40 kDa regulated in adipocytes
    transmembrane domain protein regulated in adipocytes 40 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410580.1 → NP_001397509.1  transmembrane protein adipocyte-associated 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153923

    2. NM_001410581.1 → NP_001397510.1  transmembrane protein adipocyte-associated 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153923

    3. NM_011906.3 → NP_036036.2  transmembrane protein adipocyte-associated 1 isoform 1

      See identical proteins and their annotated locations for NP_036036.2

      Status: VALIDATED

      Source sequence(s)
      AC153923
      Consensus CDS
      CCDS39555.1
      UniProtKB/Swiss-Prot
      Q80UD9, Q8C240, Q91Z36, Q99MU1, Q9Z112
      Related
      ENSMUSP00000145050.2, ENSMUST00000204765.3
      Conserved Domains (1) summary
      pfam10160
      Location:36 → 309
      Tmemb_40; Predicted membrane protein

    RNA

    1. NR_177087.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153923

    2. NR_177088.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153923

    3. NR_177089.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153923

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      88879238..88889216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166106.1 → XP_036021999.1  transmembrane protein adipocyte-associated 1 isoform X1

      UniProtKB/Swiss-Prot
      Q80UD9, Q8C240, Q91Z36, Q99MU1, Q9Z112
      Conserved Domains (1) summary
      pfam10160
      Location:36 → 309
      Tmemb_40; Predicted membrane protein

    2. XM_006506063.3 → XP_006506126.1  transmembrane protein adipocyte-associated 1 isoform X1

      See identical proteins and their annotated locations for XP_006506126.1

      UniProtKB/Swiss-Prot
      Q80UD9, Q8C240, Q91Z36, Q99MU1, Q9Z112
      Related
      ENSMUSP00000145168.2, ENSMUST00000203185.3
      Conserved Domains (1) summary
      pfam10160
      Location:36 → 309
      Tmemb_40; Predicted membrane protein

    3. XM_036166107.1 → XP_036022000.1  transmembrane protein adipocyte-associated 1 isoform X1

      UniProtKB/Swiss-Prot
      Q80UD9, Q8C240, Q91Z36, Q99MU1, Q9Z112
      Conserved Domains (1) summary
      pfam10160
      Location:36 → 309
      Tmemb_40; Predicted membrane protein

    4. XM_006506062.3 → XP_006506125.1  transmembrane protein adipocyte-associated 1 isoform X1

      See identical proteins and their annotated locations for XP_006506125.1

      UniProtKB/Swiss-Prot
      Q80UD9, Q8C240, Q91Z36, Q99MU1, Q9Z112
      Conserved Domains (1) summary
      pfam10160
      Location:36 → 309
      Tmemb_40; Predicted membrane protein

    5. XM_006506061.4 → XP_006506124.1  transmembrane protein adipocyte-associated 1 isoform X1

      See identical proteins and their annotated locations for XP_006506124.1

      UniProtKB/Swiss-Prot
      Q80UD9, Q8C240, Q91Z36, Q99MU1, Q9Z112
      Conserved Domains (1) summary
      pfam10160
      Location:36 → 309
      Tmemb_40; Predicted membrane protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MU1.1 GenPept UniProtKB/Swiss-Prot:Q99MU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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