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    Tekt2 tektin 2 [ Mus musculus (house mouse) ]

    Gene ID: 24084, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tekt2provided by MGI
    Official Full Name
    tektin 2provided by MGI
    Primary source
    MGI:MGI:1346335
    See related
    Ensembl:ENSMUSG00000028845 AllianceGenome:MGI:1346335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tektin-t
    Summary
    Acts upstream of or within flagellated sperm motility and inner dynein arm assembly. Located in microtubule organizing center. Is expressed in islets of Langerhans; pancreas; pancreas primordium; pancreas trunk epithelium; and pancreatic duct. Orthologous to human TEKT2 (tektin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 147.5) and limb E14.5 (RPKM 8.4) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 60.37 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126215914..126219481, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126322121..126325688, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene collagen, type VIII, alpha 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:125998967-125999150 Neighboring gene ADP-ribosylserine hydrolase Neighboring gene STARR-seq mESC enhancer starr_11400 Neighboring gene argonaute RISC catalytic subunit 3 Neighboring gene STARR-seq mESC enhancer starr_11401 Neighboring gene STARR-positive B cell enhancer ABC_E7988 Neighboring gene argonaute RISC catalytic subunit 1 Neighboring gene STARR-seq mESC enhancer starr_11403 Neighboring gene STARR-positive B cell enhancer ABC_E2714

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tektin 2 is required for central spindle microtubule organization and the completion of cytokinesis. Durcan TM, et al. J Cell Biol, 2008 May 19. PMID 18474621, Free PMC Article
    2. Molecular cloning of haploid germ cell-specific tektin cDNA and analysis of the protein in mouse testis. Iguchi N, et al. FEBS Lett, 1999 Aug 6. PMID 10456331
    3. Tektin 4 is located on outer dense fibers, not associated with axonemal tubulins of flagella in rodent spermatozoa. Iida H, et al. Mol Reprod Dev, 2006 Jul. PMID 16596631
    4. Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function. Tanaka H, et al. Mol Cell Biol, 2004 Sep. PMID 15340058, Free PMC Article
    5. Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor. Yoshida T, et al. FEBS Lett, 1999 Sep 10. PMID 10518929

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tek2-dependent organization of the central spindle during anaphase is essential for proper midbody formation and the segregation of daughter cells after cytokinesis.
      Title: Tektin 2 is required for central spindle microtubule organization and the completion of cytokinesis.
    2. Tektin-t participates in dynein inner arm formation or attachment and that the loss of Tektin-t results in impaired motility of both flagella and cilia.
      Title: Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inner dynein arm assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tektin-2
    Names
    testicular tektin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357262.1 → NP_001344191.1  tektin-2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AK006205, AL606976, BG083070, BY084876, BY094167
      Consensus CDS
      CCDS18651.1
      UniProtKB/Swiss-Prot
      Q922G7, Q9WVR0
      Related
      ENSMUSP00000099676.2, ENSMUST00000102616.8
      Conserved Domains (1) summary
      pfam03148
      Location:17 → 395
      Tektin; Tektin family

    2. NM_001357263.1 → NP_001344192.1  tektin-2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AK006205, AL606976, BB603783, BG083070, BY084876, BY094167
      Consensus CDS
      CCDS18651.1
      UniProtKB/Swiss-Prot
      Q922G7, Q9WVR0
      Conserved Domains (1) summary
      pfam03148
      Location:17 → 395
      Tektin; Tektin family

    3. NM_011902.3 → NP_036032.2  tektin-2

      See identical proteins and their annotated locations for NP_036032.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) reprsents the longest transcript. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AK006205, AL606976, BG083070, BY084876, BY094167
      Consensus CDS
      CCDS18651.1
      UniProtKB/Swiss-Prot
      Q922G7, Q9WVR0
      Conserved Domains (1) summary
      pfam03148
      Location:17 → 395
      Tektin; Tektin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      126215914..126219481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922G7.1 GenPept UniProtKB/Swiss-Prot:Q922G7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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