Med24 mediator complex subunit 24 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Med24provided by MGI
Official Full Name: mediator complex subunit 24provided by MGI
Primary source: MGI:MGI:1344385
See related: Ensembl:ENSMUSG00000017210 AllianceGenome:MGI:1344385
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gse2; 911GSE; Pparb2; Thrap4; DRIP100; Pparbp2; Trap100; D11Ertd307e
Summary: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thymus adult (RPKM 41.8), testis adult (RPKM 39.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 62.46 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (98595423..98620245, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (98704597..98729419, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MED24 was identified as a crucial oncogenic target of ERBB2 in lung tumor development.
Title: ERBB2 Regulates MED24 during Cancer Progression in Mice with Pten and Smad4 Deletion in the Pulmonary Epithelium.
functional communications between the MED1 subunit and the MED24-containing submodule that mediate estrogen receptor functions and growth of both normal mammary epithelial cells and breast carcinoma cells.
Title: Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells.
genetic ablation of mouse Trap100 results in attenuation of transcriptional activation and loss of TRAP95, TRAP150beta, and TRAP100 from the TRAP/Mediator complex.
Title: The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125256 (e-PCR)
- UniSTS:162078

AU040102 (e-PCR)
- UniSTS:180307

AW547152 (e-PCR)
- UniSTS:180308

RH126835 (e-PCR)
- UniSTS:167048

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription elongation by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of core mediator complex	ISO Inferred from Sequence Orthology more info
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mediator of RNA polymerase II transcription subunit 24

Names: genetic suppressor element 2; mTRAP100; peroxisome proliferation activation receptor binding protein 2; thyroid hormone receptor associated protein 4; thyroid hormone receptor-associated protein 100 kDa; thyroid hormone receptor-associated protein complex 100 kDa component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361993.2 → NP_001348922.1 mediator of RNA polymerase II transcription subunit 24 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (2), as well as variants 1 and 5, encodes isoform 1.

Source sequence(s)

AL590963

Consensus CDS

CCDS88247.1

UniProtKB/TrEMBL

A6PW47

Conserved Domains (1) summary

pfam11277
Location:1 → 1004

Med24_N; Mediator complex subunit 24 N-terminal
NM_001361994.2 → NP_001348923.1 mediator of RNA polymerase II transcription subunit 24 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, and 5 all encode the same isoform.

Source sequence(s)

AL590963

Consensus CDS

CCDS88247.1

UniProtKB/TrEMBL

A6PW47

Conserved Domains (1) summary

pfam11277
Location:1 → 1004

Med24_N; Mediator complex subunit 24 N-terminal
NM_001361995.2 → NP_001348924.1 mediator of RNA polymerase II transcription subunit 24 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (4), as well as variants 3 and 6, encodes isoform 2.

Source sequence(s)

AL590963

Consensus CDS

CCDS25361.2

UniProtKB/Swiss-Prot

A3KFP0, Q8R004, Q99K74, Q9D277, Q9WVF1

Conserved Domains (1) summary

pfam11277
Location:1 → 985

Med24_N; Mediator complex subunit 24 N-terminal
NM_001378926.1 → NP_001365855.1 mediator of RNA polymerase II transcription subunit 24 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (5), as well as variants 1 and 2, encodes isoform 1.

Source sequence(s)

AL590963

UniProtKB/TrEMBL

A6PW47

Related

ENSMUSP00000098069.3, ENSMUST00000100500.9

Conserved Domains (1) summary

pfam11277
Location:1 → 1004

Med24_N; Mediator complex subunit 24 N-terminal
NM_001378927.1 → NP_001365856.1 mediator of RNA polymerase II transcription subunit 24 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variants 3 and 4, encodes isoform 2.

Source sequence(s)

AL590963

UniProtKB/Swiss-Prot

A3KFP0, Q8R004, Q99K74, Q9D277, Q9WVF1

Conserved Domains (1) summary

pfam11277
Location:1 → 985

Med24_N; Mediator complex subunit 24 N-terminal
NM_011869.3 → NP_035999.2 mediator of RNA polymerase II transcription subunit 24 isoform 2

See identical proteins and their annotated locations for NP_035999.2

Status: REVIEWED

Description

Transcript Variant: This variant (3), as well as variants 4 and 6, encodes isoform 2.

Source sequence(s)

AL590963

Consensus CDS

CCDS25361.2

UniProtKB/Swiss-Prot

A3KFP0, Q8R004, Q99K74, Q9D277, Q9WVF1

Related

ENSMUSP00000017354.7, ENSMUST00000017354.13

Conserved Domains (1) summary

pfam11277
Location:1 → 985

Med24_N; Mediator complex subunit 24 N-terminal