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    Oasl2 2'-5' oligoadenylate synthetase-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 23962, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Oasl2provided by MGI
    Official Full Name
    2'-5' oligoadenylate synthetase-like 2provided by MGI
    Primary source
    MGI:MGI:1344390
    See related
    Ensembl:ENSMUSG00000029561 AllianceGenome:MGI:1344390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oasl; M1204; Mmu-OASL
    Summary
    Enables 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Involved in purine nucleotide biosynthetic process. Acts upstream of or within interleukin-27-mediated signaling pathway. Predicted to be active in cytosol; membrane; and nucleoplasm. Is expressed in central nervous system; retina; and thymus primordium. Orthologous to human OASL2P (2'-5' oligoadenylate synthetase like 2, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 7.4), bladder adult (RPKM 5.9) and 25 other tissues See more
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    Genomic context

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    Location:
    5 F; 5 55.99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115034995..115050306)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114896926..114912245)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930519G04 gene Neighboring gene microRNA 6240 Neighboring gene predicted gene 9936 Neighboring gene STARR-positive B cell enhancer ABC_E6367 Neighboring gene STARR-seq mESC enhancer starr_14091 Neighboring gene predicted gene 13822 Neighboring gene 2'-5' oligoadenylate synthetase-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. M1204, a novel 2',5' oligoadenylate synthetase with a ubiquitin-like extension, is induced during maturation of murine dendritic cells. Tiefenthaler M, et al. J Immunol, 1999 Jul 15. PMID 10395668
    2. Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production. Ghosh A, et al. Immunity, 2019 Jan 15. PMID 30635239, Free PMC Article
    3. Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. Zhu J, et al. Immunity, 2014 Jun 19. PMID 24931123, Free PMC Article
    4. Expansion and molecular evolution of the interferon-induced 2'-5' oligoadenylate synthetase gene family. Kumar S, et al. Mol Biol Evol, 2000 May. PMID 10779534
    5. Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation. Bankers L, et al. J Immunol, 2020 May 15. PMID 32277054, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these resulta define distinct mechanisms by which OASL differentially regulates host IFN responses during RNA and DNA virus infection and identify OASL as a negative-feedback regulator of cGAS
      Title: Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2'-5'-oligoadenylate synthetase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2'-5'-oligoadenylate synthetase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-27-mediated signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to virus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    2'-5'-oligoadenylate synthase-like protein 2
    Names
    54 kDa 2'-5'-oligoadenylate synthase-like protein 2
    54 kDa 2'-5'-oligoadenylate synthetase-like protein 2
    p54 OASL
    NP_001346110.1
    NP_035984.2
    XP_006530377.1
    XP_006530378.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359181.1 → NP_001346110.1  2'-5'-oligoadenylate synthase-like protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC117799, AK160630
      UniProtKB/TrEMBL
      F6VMV6
      Conserved Domains (3) summary
      cd01811
      Location:107 → 186
      OASL_repeat1; 2'-5' oligoadenylate synthetase-like protein, repeat 1 of 2
      pfam10421
      Location:1 → 104
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
      cl25424
      Location:189 → 255
      TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

    2. NM_011854.2 → NP_035984.2  2'-5'-oligoadenylate synthase-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_035984.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC116500, AK010034, BY426738
      Consensus CDS
      CCDS39226.1
      UniProtKB/Swiss-Prot
      Q9D6S2, Q9Z2F2
      UniProtKB/TrEMBL
      Q8K234
      Related
      ENSMUSP00000031542.10, ENSMUST00000031542.13
      Conserved Domains (4) summary
      cd05400
      Location:29 → 214
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      cd01811
      Location:355 → 428
      Ubl1_OASL; ubiquitin-like (Ubl) domain 1 found in 2'-5'-oligoadenylate synthase-like protein (OASL) and similar proteins
      pfam10421
      Location:170 → 352
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
      cl28922
      Location:434 → 505
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115034995..115050306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530315.5 → XP_006530378.1  2'-5'-oligoadenylate synthase-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006530378.1

      UniProtKB/Swiss-Prot
      Q9D6S2, Q9Z2F2
      UniProtKB/TrEMBL
      Q8K234
      Conserved Domains (4) summary
      cd05400
      Location:29 → 214
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      cd01811
      Location:355 → 428
      Ubl1_OASL; ubiquitin-like (Ubl) domain 1 found in 2'-5'-oligoadenylate synthase-like protein (OASL) and similar proteins
      pfam10421
      Location:170 → 352
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
      cl28922
      Location:434 → 505
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_006530314.5 → XP_006530377.1  2'-5'-oligoadenylate synthase-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006530377.1

      UniProtKB/Swiss-Prot
      Q9D6S2, Q9Z2F2
      UniProtKB/TrEMBL
      Q8K234
      Conserved Domains (4) summary
      cd05400
      Location:29 → 214
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      cd01811
      Location:355 → 428
      Ubl1_OASL; ubiquitin-like (Ubl) domain 1 found in 2'-5'-oligoadenylate synthase-like protein (OASL) and similar proteins
      pfam10421
      Location:170 → 352
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
      cl28922
      Location:434 → 505
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2F2.2 GenPept UniProtKB/Swiss-Prot:Q9Z2F2

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