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    Akt3 thymoma viral proto-oncogene 3 [ Mus musculus (house mouse) ]

    Gene ID: 23797, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Akt3provided by MGI
    Official Full Name
    thymoma viral proto-oncogene 3provided by MGI
    Primary source
    MGI:MGI:1345147
    See related
    Ensembl:ENSMUSG00000019699 AllianceGenome:MGI:1345147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nmf350; D930002M15Rik
    Summary
    Predicted to enable ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of angiogenesis and positive regulation of artery morphogenesis. Acts upstream of or within several processes, including brain morphogenesis; positive regulation of TOR signaling; and positive regulation of cell size. Predicted to be located in plasma membrane. Is expressed in several structures, including genitourinary system; musculature; nervous system; retina; and skin. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 12.2), CNS E14 (RPKM 10.5) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H4; 1 82.66 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (176847642..177091688, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (177020076..177261781, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5862 Neighboring gene serologically defined colon cancer antigen 8 Neighboring gene high mobility group AT-hook 2, pseudogene 1 Neighboring gene predicted gene, 38158 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:178876211-178876412 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:178880303-178880504 Neighboring gene predicted gene 15423 Neighboring gene STARR-positive B cell enhancer ABC_E7781 Neighboring gene STARR-seq mESC enhancer starr_03123 Neighboring gene predicted gene, 36904 Neighboring gene STARR-positive B cell enhancer ABC_E11110 Neighboring gene STARR-positive B cell enhancer mm9_chr1:179371945-179372246 Neighboring gene STARR-positive B cell enhancer ABC_E3338 Neighboring gene zinc finger and BTB domain containing 18 Neighboring gene keratin 8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Akt3-Mediated Protection Against Inflammatory Demyelinating Disease. DuBois JC, et al. Front Immunol, 2019. PMID 31404142, Free PMC Article
    2. AKT3 drives adenoid cystic carcinoma development in salivary glands. Zboray K, et al. Cancer Med, 2018 Feb. PMID 29282901, Free PMC Article
    3. PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia. Howell KR, et al. PLoS One, 2017. PMID 28467426, Free PMC Article
    4. Genetic Deletion of Akt3 Induces an Endophenotype Reminiscent of Psychiatric Manifestations in Mice. Bergeron Y, et al. Front Mol Neurosci, 2017. PMID 28442992, Free PMC Article
    5. miR-29 targets Akt3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development. Wei W, et al. Cell Death Dis, 2013 Jun 13. PMID 23764849, Free PMC Article

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enhanced Akt3 kinase activity reduces atherosclerosis in hyperlipidemic mice in a gender-dependent manner.
      Title: Enhanced Akt3 kinase activity reduces atherosclerosis in hyperlipidemic mice in a gender-dependent manner.
    2. miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiO2-Induced Lung Fibrosis.
      Title: miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiO(2)-Induced Lung Fibrosis.
    3. The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.
      Title: The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.
    4. Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1.
      Title: Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1.
    5. Akt3-mTOR regulates hippocampal neurogenesis in adult mouse.
      Title: Akt3-mTOR regulates hippocampal neurogenesis in adult mouse.
    6. Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p/E-cadherin signals.
      Title: Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p/E-cadherin signals.
    7. AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupting tissue remodeling.
      Title: AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupting tissue remodeling.
    8. Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox).
      Title: Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox).
    9. Specific Akt Family Members Impair Stress-Mediated Transactivation of Viral Promoters and Enhance Neuronal Differentiation: Important Functions for Maintaining Latency.
      Title: Specific Akt Family Members Impair Stress-Mediated Transactivation of Viral Promoters and Enhance Neuronal Differentiation: Important Functions for Maintaining Latency.
    10. Depletion of Siah1 enhanced Akt3 levels in the soma and axonal tips, eliciting multiple branching.
      Title: SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial genome maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RAC-gamma serine/threonine-protein kinase
    Names
    PKB gamma
    RAC-PK-gamma
    protein kinase Akt-3
    protein kinase B gamma
    NP_035915.3
    XP_006496881.1
    XP_006496882.1
    XP_011237107.1
    XP_030109770.1
    XP_030109777.1
    XP_036020522.1
    XP_036020523.1
    XP_036020524.1
    XP_036020525.1
    XP_036020526.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011785.4 → NP_035915.3  RAC-gamma serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_035915.3

      Status: VALIDATED

      Source sequence(s)
      AC130843, AC163009, AK052953, BF455585, CD578931
      Consensus CDS
      CCDS35799.1
      UniProtKB/Swiss-Prot
      Q9WUA6
      UniProtKB/TrEMBL
      Q6NXW0
      Related
      ENSMUSP00000106790.3, ENSMUST00000111160.9
      Conserved Domains (2) summary
      cd01241
      Location:4 → 110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05593
      Location:132 → 479
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      176847642..177091688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164629.1 → XP_036020522.1  RAC-gamma serine/threonine-protein kinase isoform X3

      UniProtKB/TrEMBL
      Q6NXW0
      Conserved Domains (2) summary
      cd01241
      Location:4 → 110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cl21453
      Location:132 → 438
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006496818.5 → XP_006496881.1  RAC-gamma serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006496881.1

      UniProtKB/Swiss-Prot
      Q9WUA6
      UniProtKB/TrEMBL
      Q6NXW0
      Related
      ENSMUSP00000106789.2, ENSMUST00000111159.2
      Conserved Domains (2) summary
      cd01241
      Location:4 → 110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05593
      Location:132 → 479
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

    3. XM_036164632.1 → XP_036020525.1  RAC-gamma serine/threonine-protein kinase isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:46 → 292
      PKc_like; Protein Kinases, catalytic domain

    4. XM_036164631.1 → XP_036020524.1  RAC-gamma serine/threonine-protein kinase isoform X6

      Conserved Domains (1) summary
      cd05593
      Location:16 → 363
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

    5. XM_036164630.1 → XP_036020523.1  RAC-gamma serine/threonine-protein kinase isoform X5

      Conserved Domains (2) summary
      cl17171
      Location:1 → 49
      PH-like; Pleckstrin homology-like domain
      cl21453
      Location:71 → 377
      PKc_like; Protein Kinases, catalytic domain

    6. XM_030253917.2 → XP_030109777.1  RAC-gamma serine/threonine-protein kinase isoform X4

      UniProtKB/TrEMBL
      Q6NXW0
      Conserved Domains (2) summary
      cd05593
      Location:71 → 418
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
      cl17171
      Location:1 → 49
      PH-like; Pleckstrin homology-like domain

    7. XM_030253910.1 → XP_030109770.1  RAC-gamma serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      Q9WUA6
      UniProtKB/TrEMBL
      Q6NXW0
      Conserved Domains (2) summary
      cd01241
      Location:4 → 110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05593
      Location:132 → 479
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

    8. XM_036164633.1 → XP_036020526.1  RAC-gamma serine/threonine-protein kinase isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:46 → 292
      PKc_like; Protein Kinases, catalytic domain

    9. XM_006496819.5 → XP_006496882.1  RAC-gamma serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006496882.1

      UniProtKB/Swiss-Prot
      Q9WUA6
      UniProtKB/TrEMBL
      Q6NXW0
      Conserved Domains (2) summary
      cd01241
      Location:4 → 110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05593
      Location:132 → 479
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

    10. XM_011238805.4 → XP_011237107.1  RAC-gamma serine/threonine-protein kinase isoform X2

      UniProtKB/TrEMBL
      Q6NXW0
      Conserved Domains (2) summary
      cd01241
      Location:4 → 110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cl21453
      Location:152 → 417
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUA6.1 GenPept UniProtKB/Swiss-Prot:Q9WUA6

    Gene LinkOut

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