Nrn1l neuritin 1-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrn1lprovided by MGI
Official Full Name: neuritin 1-likeprovided by MGI
Primary source: MGI:MGI:2443642
See related: Ensembl:ENSMUSG00000044287 AllianceGenome:MGI:2443642
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cpg15-2; G630049C14Rik
Summary: Enables identical protein binding activity. Acts upstream of or within neuron projection extension. Located in axon; extracellular space; and membrane. Is anchored component of plasma membrane. Is expressed in brain; eye; genitourinary system; and pancreas. Orthologous to human NRN1L (neuritin 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 4.1), adrenal adult (RPKM 2.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.06 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106620199..106621655)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (105893567..105895023)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CPG15 and CPG15-2 perform similar cellular functions but may play distinct roles in vivo through their cell-type- and tissue-specific transcriptional regulation
Title: cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection extension	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection extension	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuritin-like protein

Names: MRCC2446-like protein; candidate plasticity gene 15-2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301174.1 → NP_001288103.1 neuritin-like protein isoform 2 precursor

See identical proteins and their annotated locations for NP_001288103.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AK080711, BC100315, CK030777

Consensus CDS

CCDS80924.1

UniProtKB/Swiss-Prot

Q8C4W3

Related

ENSMUSP00000113445.2, ENSMUST00000118920.2

Conserved Domains (1) summary

pfam15056
Location:38 → 113

NRN1; Neuritin protein family
NM_175024.4 → NP_778189.1 neuritin-like protein isoform 1 precursor

See identical proteins and their annotated locations for NP_778189.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC100315, CK030777

Consensus CDS

CCDS22618.1

UniProtKB/Swiss-Prot

Q8BN06, Q8C4W3

Related

ENSMUSP00000056940.6, ENSMUST00000060167.6

Conserved Domains (1) summary

pfam15056
Location:39 → 114

NRN1; Neuritin protein family