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    Ccdc124 coiled-coil domain containing 124 [ Mus musculus (house mouse) ]

    Gene ID: 234388, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ccdc124provided by MGI
    Official Full Name
    coiled-coil domain containing 124provided by MGI
    Primary source
    MGI:MGI:1916403
    See related
    Ensembl:ENSMUSG00000007721 AllianceGenome:MGI:1916403
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810023B24Rik
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to act upstream of or within cell division. Predicted to be located in cytosol and plasma membrane. Predicted to be active in nucleus. Orthologous to human CCDC124 (coiled-coil domain containing 124). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 50.0), frontal lobe adult (RPKM 46.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc124 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.33 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71320870..71326134, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70868226..70873490, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E133 Neighboring gene arrestin domain containing 2 Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E3780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73389712-73389895 Neighboring gene STARR-positive B cell enhancer ABC_E8242 Neighboring gene STARR-seq mESC enhancer starr_21801 Neighboring gene solute carrier family 5 (sodium iodide symporter), member 5 Neighboring gene ribosomal protein L18A Neighboring gene microRNA 7067

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
    2. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    3. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 124

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026964.3 → NP_081240.1  coiled-coil domain-containing protein 124

      See identical proteins and their annotated locations for NP_081240.1

      Status: PROVISIONAL

      Source sequence(s)
      AC019302
      Consensus CDS
      CCDS22384.1
      UniProtKB/Swiss-Prot
      Q8C2T0, Q9D8X2
      Related
      ENSMUSP00000007865.6, ENSMUST00000007865.7
      Conserved Domains (1) summary
      pfam06244
      Location:95 → 206
      Ccdc124; Coiled-coil domain-containing protein 124

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71320870..71326134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153949.1 → XP_036009842.1  coiled-coil domain-containing protein 124 isoform X1

      UniProtKB/Swiss-Prot
      Q8C2T0, Q9D8X2
      Conserved Domains (1) summary
      pfam06244
      Location:95 → 206
      Ccdc124; Coiled-coil domain-containing protein 124

    2. XM_006509655.4 → XP_006509718.1  coiled-coil domain-containing protein 124 isoform X1

      See identical proteins and their annotated locations for XP_006509718.1

      UniProtKB/Swiss-Prot
      Q8C2T0, Q9D8X2
      Conserved Domains (1) summary
      pfam06244
      Location:95 → 206
      Ccdc124; Coiled-coil domain-containing protein 124
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8X2.1 GenPept UniProtKB/Swiss-Prot:Q9D8X2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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