Tpte transmembrane phosphatase with tensin homology [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tpteprovided by MGI
Official Full Name: transmembrane phosphatase with tensin homologyprovided by MGI
Primary source: MGI:MGI:2446460
See related: Ensembl:ENSMUSG00000031481 AllianceGenome:MGI:2446460
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vsp; Pten2
Summary: Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including dephosphorylation; phosphatidylinositol 3-kinase signaling; and regulation of protein kinase B signaling. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including cytosol; nucleus; and plasma membrane. Is expressed in brain; eye; future spinal cord; surface ectoderm; and testis. Orthologous to several human genes including TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 1.2), kidney adult (RPKM 0.2) and 6 other tissues See more
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Genomic context

Location:: 8 A2; 8 11.2 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (22773457..22861432)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (22283315..22371418)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mmumiR449a may ameliorate neuropathic pain by decreasing the activity of the channel proteins TRPA1 and KCNMA1 and increasing the levels of TPTE.
Title: Mus musculus-microRNA-449a ameliorates neuropathic pain by decreasing the level of KCNMA1 and TRPA1, and increasing the level of TPTE.
the TPIP splice-variant (TPIP-C2) mRNA is expressed in human and mouse tissues and strongly inhibits cell growth in HeLa cells
Title: A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Tpte (e-PCR), detects polymorphism
- UniSTS:254230

Tpte (e-PCR), detects polymorphism
- UniSTS:259666

Tpte (e-PCR), detects polymorphism
- UniSTS:259161

D8Mit257 (e-PCR), detects polymorphism
- UniSTS:131466

10.MMHAP3FRD7.seq (e-PCR)
- UniSTS:123028

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISA Inferred from Sequence Alignment more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane phosphatase with tensin homology

NP_954866.2

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199257.3 → NP_954866.2 transmembrane phosphatase with tensin homology

See identical proteins and their annotated locations for NP_954866.2

Status: VALIDATED

Source sequence(s)

AC121933, AC140326

Consensus CDS

CCDS22173.1

UniProtKB/TrEMBL

G5E8H5, Q3KNE1

Related

ENSMUSP00000076435.2, ENSMUST00000077194.2

Conserved Domains (2) summary

smart00404
Location:413 → 478

PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif

pfam10409
Location:529 → 663

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

22773457..22861432

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_181851.3: Suppressed sequence

Description

NM_181851.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_199258.1: Suppressed sequence

Description

NM_199258.1: This RefSeq was permanently suppressed because it contains the wrong CDS.