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    Tnrc6a trinucleotide repeat containing 6a [ Mus musculus (house mouse) ]

    Gene ID: 233833, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tnrc6aprovided by MGI
    Official Full Name
    trinucleotide repeat containing 6aprovided by MGI
    Primary source
    MGI:MGI:2385292
    See related
    Ensembl:ENSMUSG00000052707 AllianceGenome:MGI:2385292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GW182; Tnrc6; CAGH26; 2010321I05Rik; 3110054G10Rik; D130023A07Rik
    Summary
    This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein is highly similar to a human protein that functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The human protein associates with messenger RNAs and argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies, and inhibiting its expression delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 14.3), CNS E14 (RPKM 13.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F2- F3; 7 67.42 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (122630324..122794519)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (123031101..123195296)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L11 pseudogene Neighboring gene predicted gene, 51498 Neighboring gene VISTA enhancer mm1484 Neighboring gene predicted gene, 39084 Neighboring gene STARR-seq mESC enhancer starr_20085 Neighboring gene STARR-positive B cell enhancer ABC_E11366 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:130281644-130281845 Neighboring gene STARR-seq mESC enhancer starr_20086 Neighboring gene STARR-seq mESC enhancer starr_20088 Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 11 Neighboring gene STARR-seq mESC enhancer starr_20089 Neighboring gene STARR-seq mESC enhancer starr_20090 Neighboring gene Rho GTPase activating protein 17 Neighboring gene STARR-positive B cell enhancer ABC_E4974 Neighboring gene STARR-seq mESC enhancer starr_20097

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GW bodies, microRNAs and the cell cycle. Lian S, et al. Cell Cycle, 2006 Feb. PMID 16418578
    2. In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA. La Rocca G, et al. Proc Natl Acad Sci U S A, 2015 Jan 20. PMID 25568082, Free PMC Article
    3. miR-30 family microRNAs regulate myogenic differentiation and provide negative feedback on the microRNA pathway. Guess MG, et al. PLoS One, 2015. PMID 25689854, Free PMC Article
    4. RBM19 is essential for preimplantation development in the mouse. Zhang J, et al. BMC Dev Biol, 2008 Dec 16. PMID 19087264, Free PMC Article
    5. GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. Yang Z, et al. J Cell Sci, 2004 Nov 1. PMID 15494374

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GW182 is an essential functional component in the RNA-induced silencing complex for miRNA-mediated gene silencing in vivo
      Title: Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11932

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of protein location in cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in miRNA-mediated gene silencing by inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA-mediated post-transcriptional gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of RISC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trinucleotide repeat-containing gene 6A protein
    Names
    GW182 autoantigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144925.3 → NP_659174.3  trinucleotide repeat-containing gene 6A protein

      Status: VALIDATED

      Source sequence(s)
      AC138364, AK147327, BF020619, BY720212, CD802917
      Consensus CDS
      CCDS57583.1
      UniProtKB/Swiss-Prot
      F6ZMJ4, Q3UHK8
      Related
      ENSMUSP00000091595.6, ENSMUST00000094053.7
      Conserved Domains (4) summary
      cd12711
      Location:1715 → 1797
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1060 → 1185
      Ago_hook; Argonaute hook
      pfam12938
      Location:1266 → 1416
      M_domain; M domain of GW182
      pfam16608
      Location:1439 → 1702
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      122630324..122794519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241757.1 → XP_011240059.1  trinucleotide repeat-containing gene 6A protein isoform X1

      Conserved Domains (4) summary
      cd12711
      Location:1773 → 1855
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1069 → 1194
      Ago_hook; Argonaute hook
      pfam12938
      Location:1289 → 1474
      M_domain; M domain of GW182
      pfam16608
      Location:1497 → 1760
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    2. XM_017322202.1 → XP_017177691.1  trinucleotide repeat-containing gene 6A protein isoform X6

      Conserved Domains (4) summary
      cd12711
      Location:1773 → 1855
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1069 → 1194
      Ago_hook; Argonaute hook
      pfam12938
      Location:1289 → 1474
      M_domain; M domain of GW182
      pfam16608
      Location:1497 → 1760
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    3. XM_011241760.2 → XP_011240062.1  trinucleotide repeat-containing gene 6A protein isoform X5

      Conserved Domains (4) summary
      cd12711
      Location:1750 → 1832
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1069 → 1194
      Ago_hook; Argonaute hook
      pfam12938
      Location:1289 → 1378
      M_domain; M domain of GW182
      pfam16608
      Location:1474 → 1737
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    4. XM_011241762.2 → XP_011240064.1  trinucleotide repeat-containing gene 6A protein isoform X7

      Conserved Domains (4) summary
      cd12711
      Location:1724 → 1806
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1069 → 1194
      Ago_hook; Argonaute hook
      pfam12938
      Location:1275 → 1425
      M_domain; M domain of GW182
      pfam16608
      Location:1448 → 1711
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    5. XM_017322203.2 → XP_017177692.1  trinucleotide repeat-containing gene 6A protein isoform X10

      Conserved Domains (4) summary
      cd12711
      Location:1701 → 1783
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1069 → 1194
      Ago_hook; Argonaute hook
      pfam12938
      Location:1275 → 1329
      M_domain; M domain of GW182
      pfam16608
      Location:1425 → 1688
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    6. XM_011241758.2 → XP_011240060.1  trinucleotide repeat-containing gene 6A protein isoform X3

      Conserved Domains (4) summary
      cd12711
      Location:1762 → 1844
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1069 → 1183
      Ago_hook; Argonaute hook
      pfam12938
      Location:1278 → 1463
      M_domain; M domain of GW182
      pfam16608
      Location:1486 → 1749
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    7. XM_011241763.2 → XP_011240065.1  trinucleotide repeat-containing gene 6A protein isoform X9

      Conserved Domains (4) summary
      cd12711
      Location:1713 → 1795
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1069 → 1183
      Ago_hook; Argonaute hook
      pfam12938
      Location:1264 → 1414
      M_domain; M domain of GW182
      pfam16608
      Location:1437 → 1700
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    8. XM_036153008.1 → XP_036008901.1  trinucleotide repeat-containing gene 6A protein isoform X12

      Conserved Domains (5) summary
      pfam10427
      Location:1069 → 1183
      Ago_hook; Argonaute hook
      pfam12938
      Location:1264 → 1318
      M_domain; M domain of GW182
      pfam16608
      Location:1416 → 1677
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12711
      Location:1685 → 1776
      RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
      NF033849
      Location:596 → 854
      ser_rich_anae_1; serine-rich protein

    9. XM_011241764.2 → XP_011240066.1  trinucleotide repeat-containing gene 6A protein isoform X15

      Conserved Domains (2) summary
      pfam10427
      Location:1069 → 1194
      Ago_hook; Argonaute hook
      pfam12938
      Location:1289 → 1361
      M_domain; M domain of GW182

    10. XM_011241765.3 → XP_011240067.1  trinucleotide repeat-containing gene 6A protein isoform X16

      UniProtKB/TrEMBL
      Q05CE3
      Conserved Domains (1) summary
      pfam10427
      Location:1069 → 1161
      Ago_hook; Argonaute hook

    11. XM_006507705.3 → XP_006507768.1  trinucleotide repeat-containing gene 6A protein isoform X2

      Conserved Domains (4) summary
      cd12711
      Location:1764 → 1846
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1060 → 1185
      Ago_hook; Argonaute hook
      pfam12938
      Location:1280 → 1465
      M_domain; M domain of GW182
      pfam16608
      Location:1488 → 1751
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    12. XM_017322204.3 → XP_017177693.1  trinucleotide repeat-containing gene 6A protein isoform X11

      Conserved Domains (4) summary
      cd12711
      Location:1692 → 1774
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1060 → 1185
      Ago_hook; Argonaute hook
      pfam12938
      Location:1266 → 1320
      M_domain; M domain of GW182
      pfam16608
      Location:1416 → 1679
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    13. XM_017322201.3 → XP_017177690.1  trinucleotide repeat-containing gene 6A protein isoform X4

      Conserved Domains (4) summary
      cd12711
      Location:1753 → 1835
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:1060 → 1174
      Ago_hook; Argonaute hook
      pfam12938
      Location:1269 → 1454
      M_domain; M domain of GW182
      pfam16608
      Location:1477 → 1740
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    14. XM_017322205.3 → XP_017177694.1  trinucleotide repeat-containing gene 6A protein isoform X13

      UniProtKB/TrEMBL
      A0A0U1RQ65
      Conserved Domains (4) summary
      cd12711
      Location:1509 → 1591
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:805 → 930
      Ago_hook; Argonaute hook
      pfam12938
      Location:1025 → 1210
      M_domain; M domain of GW182
      pfam16608
      Location:1233 → 1496
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    15. XM_036153009.1 → XP_036008902.1  trinucleotide repeat-containing gene 6A protein isoform X14

      UniProtKB/TrEMBL
      A0A0U1RQ65
      Conserved Domains (5) summary
      pfam10427
      Location:805 → 930
      Ago_hook; Argonaute hook
      pfam12938
      Location:1011 → 1161
      M_domain; M domain of GW182
      pfam16608
      Location:1186 → 1447
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12711
      Location:1455 → 1546
      RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
      NF033849
      Location:332 → 590
      ser_rich_anae_1; serine-rich protein

    16. XM_017322206.3 → XP_017177695.1  trinucleotide repeat-containing gene 6A protein isoform X13

      UniProtKB/TrEMBL
      A0A0U1RQ65
      Related
      ENSMUSP00000146266.2, ENSMUST00000205760.2
      Conserved Domains (4) summary
      cd12711
      Location:1509 → 1591
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:805 → 930
      Ago_hook; Argonaute hook
      pfam12938
      Location:1025 → 1210
      M_domain; M domain of GW182
      pfam16608
      Location:1233 → 1496
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    17. XM_036153010.1 → XP_036008903.1  trinucleotide repeat-containing gene 6A protein isoform X14

      UniProtKB/TrEMBL
      A0A0U1RQ65
      Conserved Domains (5) summary
      pfam10427
      Location:805 → 930
      Ago_hook; Argonaute hook
      pfam12938
      Location:1011 → 1161
      M_domain; M domain of GW182
      pfam16608
      Location:1186 → 1447
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12711
      Location:1455 → 1546
      RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
      NF033849
      Location:332 → 590
      ser_rich_anae_1; serine-rich protein

    18. XM_036153007.1 → XP_036008900.1  trinucleotide repeat-containing gene 6A protein isoform X8

      Conserved Domains (5) summary
      pfam10427
      Location:1016 → 1141
      Ago_hook; Argonaute hook
      pfam12938
      Location:1236 → 1421
      M_domain; M domain of GW182
      pfam16608
      Location:1446 → 1707
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12711
      Location:1715 → 1806
      RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
      NF033849
      Location:543 → 801
      ser_rich_anae_1; serine-rich protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHK8.2 GenPept UniProtKB/Swiss-Prot:Q3UHK8

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