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    Tubgcp5 tubulin, gamma complex component 5 [ Mus musculus (house mouse) ]

    Gene ID: 233276, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tubgcp5provided by MGI
    Official Full Name
    tubulin, gamma complex component 5provided by MGI
    Primary source
    MGI:MGI:2178836
    See related
    Ensembl:ENSMUSG00000033790 AllianceGenome:MGI:2178836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GCP5; mKIAA1899; B130010C12Rik
    Summary
    Predicted to enable gamma-tubulin binding activity and microtubule binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Predicted to be located in cytosol. Predicted to be part of gamma-tubulin large complex. Predicted to be active in centrosome and equatorial microtubule organizing center. Orthologous to human TUBGCP5 (tubulin gamma complex associated protein 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 4.1), CNS E11.5 (RPKM 4.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B5; 7 33.42 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (55443873..55481207)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (55794125..55831459)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26482 Neighboring gene STARR-seq mESC enhancer starr_18955 Neighboring gene sialic acid binding Ig-like lectin H Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:63049366-63049475 Neighboring gene STARR-seq mESC enhancer starr_18956 Neighboring gene STARR-positive B cell enhancer mm9_chr7:63113113-63113414 Neighboring gene cytoplasmic FMR1 interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_18959 Neighboring gene peroxiredoxin 3 pseudogene Neighboring gene non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assembly of gamma-tubulin ring complexes: implications for cell biology and disease. Remy MH, et al. Prog Mol Biol Transl Sci, 2013. PMID 23663981
    2. Gamma-tubulin complexes and their interaction with microtubule-organizing centers. Wiese C, et al. Curr Opin Struct Biol, 1999 Apr. PMID 10322210
    3. Gamma-tubulin complexes: size does matter. Jeng R, et al. Trends Cell Biol, 1999 Sep. PMID 10461186
    4. Microtubule nucleation by γ-tubulin complexes. Kollman JM, et al. Nat Rev Mol Cell Biol, 2011 Oct 12. PMID 21993292, Free PMC Article
    5. Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. Chai JH, et al. Am J Hum Genet, 2003 Oct. PMID 14508708, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. indentification on mouse chromosome 7C
      Title: Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC38608

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in equatorial microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin ring complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-tubulin complex component 5
    Names
    tubulin, gamma complex associated protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360873.1 → NP_001347802.1  gamma-tubulin complex component 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102298, AC160534, AK152033
      Consensus CDS
      CCDS90246.1
      Related
      ENSMUSP00000146111.2, ENSMUST00000205796.2
      Conserved Domains (1) summary
      pfam04130
      Location:273 → 879
      Spc97_Spc98; Spc97 / Spc98 family

    2. NM_001360874.1 → NP_001347803.1  gamma-tubulin complex component 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102298, AC160534
      UniProtKB/TrEMBL
      Q8R2X3
      Conserved Domains (1) summary
      pfam04130
      Location:1 → 659
      Spc97_Spc98; Spc97 / Spc98 family

    3. NM_146190.3 → NP_666302.2  gamma-tubulin complex component 5 isoform 1

      See identical proteins and their annotated locations for NP_666302.2

      Status: VALIDATED

      Source sequence(s)
      AC160534, AI608079, AK044887, AK051326, BB859898
      Consensus CDS
      CCDS21314.1
      UniProtKB/Swiss-Prot
      Q3U8X5, Q69Z75, Q8BKN5, Q8BLJ9, Q8C083
      Related
      ENSMUSP00000032627.4, ENSMUST00000032627.5
      Conserved Domains (1) summary
      pfam04130
      Location:273 → 942
      Spc97_Spc98; Spc97 / Spc98 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      55443873..55481207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540835.5 → XP_006540898.2  gamma-tubulin complex component 5 isoform X1

      Conserved Domains (1) summary
      cl37603
      Location:271 → 581
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    RNA

    1. XR_882029.4 RNA Sequence

    2. XR_003946456.2 RNA Sequence

      Related
      ENSMUST00000206191.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BKN5.2 GenPept UniProtKB/Swiss-Prot:Q8BKN5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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