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    Scgb2b27 secretoglobin, family 2B, member 27 [ Mus musculus (house mouse) ]

    Gene ID: 233099, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Scgb2b27provided by MGI
    Official Full Name
    secretoglobin, family 2B, member 27provided by MGI
    Primary source
    MGI:MGI:87863
    See related
    Ensembl:ENSMUSG00000066584 AllianceGenome:MGI:87863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Abpbg5; Abpbg27; Scgb2b5
    Summary
    Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Scgb2b27 in Genome Data Viewer
    Location:
    7 B1; 7 19.38 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (33711344..33713367, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (34011919..34013942, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 329 pseudogene Neighboring gene predicted gene 12755 Neighboring gene STARR-seq mESC enhancer starr_18574 Neighboring gene secretoglobin, family 1B, member 27 Neighboring gene STARR-seq mESC enhancer starr_18576 Neighboring gene 60S ribosomal protein L21-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Studies of an Androgen-Binding Protein Knockout Corroborate a Role for Salivary ABP in Mouse Communication. Chung AG, et al. Genetics, 2017 Apr. PMID 28159752, Free PMC Article
    2. The amino acid sequence of the alpha subunit of mouse salivary androgen-binding protein (ABP), with a comparison to the partial sequence of the beta subunit and to other ligand-binding proteins. Karn RC, et al. Biochem Genet, 1993 Aug. PMID 8274137
    3. Congenic strain analysis reveals genes that are rapidly evolving components of a prezygotic isolation mechanism mediating incipient reinforcement. Laukaitis CM, et al. PLoS One, 2012. PMID 22558260, Free PMC Article
    4. The microevolution of mouse salivary androgen-binding protein (ABP) paralleled subspeciation of Mus musculus. Hwang JM, et al. J Hered, 1997 Mar-Apr. PMID 9099004
    5. Characterization of two forms of mouse salivary androgen-binding protein (ABP): implications for evolutionary relationships and ligand-binding function. Karn RC, et al. Biochemistry, 2003 Jun 17. PMID 12795612

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ABP subunit BG27 shares phylogenetic relationships with Fel d 1 chains.
      Title: Another cat and mouse game: Deciphering the evolution of the SCGB superfamily and exploring the molecular similarity of major cat allergen Fel d 1 and mouse ABP using computational approaches.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC19070, MGC156367

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secretoglobin, family 2B, member 27
    Names
    allergen dI chain C2A
    androgen binding protein beta
    secretoglobin, family 2B, member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100464.2 → NP_001093934.1  secretoglobin, family 2B, member 27 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001093934.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BK000193, BX539309
      Consensus CDS
      CCDS52200.1
      UniProtKB/TrEMBL
      A0A7H1MFN9, A0A7S8WJW3, Q7TNY5, Q8R1E9
      Related
      ENSMUSP00000082760.3, ENSMUST00000085620.9
      Conserved Domains (1) summary
      pfam09252
      Location:24 → 90
      Feld-I_B; Allergen Fel d I-B chain

    2. NM_001276475.1 → NP_001263404.1  secretoglobin, family 2B, member 27 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001263404.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BK000193, BX539309
      Consensus CDS
      CCDS80703.1
      UniProtKB/TrEMBL
      A0A087WRN7
      Related
      ENSMUSP00000140711.2, ENSMUST00000185399.2
      Conserved Domains (1) summary
      pfam09252
      Location:24 → 82
      Feld-I_B; Allergen Fel d I-B chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      33711344..33713367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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