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    U2af1l4 U2 small nuclear RNA auxiliary factor 1-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 233073, updated on 5-Mar-2024

    Summary

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    Official Symbol
    U2af1l4provided by MGI
    Official Full Name
    U2 small nuclear RNA auxiliary factor 1-like 4provided by MGI
    Primary source
    MGI:MGI:2678374
    See related
    Ensembl:ENSMUSG00000078765 AllianceGenome:MGI:2678374
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    U2af26
    Summary
    Predicted to enable pre-mRNA 3'-splice site binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U2AF complex and spliceosomal complex. Orthologous to human U2AF1L4 (U2 small nuclear RNA auxiliary factor 1 like 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 30.6), duodenum adult (RPKM 22.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B1; 7 18.61 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30262765..30264789)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30563340..30565364)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene microRNA 9769 Neighboring gene heat shock protein, alpha-crystallin-related, B6 Neighboring gene lin-37 DREAM MuvB core complex component Neighboring gene STARR-positive B cell enhancer ABC_E870 Neighboring gene STARR-positive B cell enhancer ABC_E1338 Neighboring gene STARR-positive B cell enhancer ABC_E4917 Neighboring gene presenilin enhancer gamma secretase subunit Neighboring gene IGF-like family receptor 1 Neighboring gene lysine (K)-specific methyltransferase 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice. Preußner M, et al. Mol Cell, 2014 May 22. PMID 24837677
    2. Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26. Heyd F, et al. J Biol Chem, 2008 Jul 11. PMID 18460468
    3. Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing. Heyd F, et al. Nat Immunol, 2006 Aug. PMID 16819553
    4. Characterization of U2AF(6), a splicing factor related to U2AF(35). Shepard J, et al. Mol Cell Biol, 2002 Jan. PMID 11739736, Free PMC Article
    5. USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation. Goldbraikh D, et al. EMBO Rep, 2020 Apr 3. PMID 32133736, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest light-induced U2af26 alternative splicing to be a buffering mechanism that limits PERIOD1 induction, thus stabilizing the circadian clock against abnormal changes in light:dark conditions.
      Title: Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice.
    2. Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26
      Title: Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables pre-mRNA 3'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U2AF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor U2AF 26 kDa subunit
    Names
    U2 auxiliary factor 26
    U2 small nuclear RNA auxiliary factor 1-like protein 4
    U2AF1-like 4
    auxiliary factor 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_170760.3 → NP_739566.1  splicing factor U2AF 26 kDa subunit

      See identical proteins and their annotated locations for NP_739566.1

      Status: PROVISIONAL

      Source sequence(s)
      AC167970
      Consensus CDS
      CCDS21100.1
      UniProtKB/Swiss-Prot
      Q8BGJ9
      UniProtKB/TrEMBL
      E9Q5J3
      Related
      ENSMUSP00000039406.10, ENSMUST00000043273.16
      Conserved Domains (2) summary
      pfam00642
      Location:149 → 175
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cd12538
      Location:43 → 146
      RRM_U2AF35; RNA recognition motif (RRM) found in U2 small nuclear ribonucleoprotein auxiliary factor U2AF 35 kDa subunit (U2AF35)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30262765..30264789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGJ9.1 GenPept UniProtKB/Swiss-Prot:Q8BGJ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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