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    Rasgrp4 RAS guanyl releasing protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 233046, updated on 21-Apr-2024

    Summary

    Official Symbol
    Rasgrp4provided by MGI
    Official Full Name
    RAS guanyl releasing protein 4provided by MGI
    Primary source
    MGI:MGI:2386851
    See related
    Ensembl:ENSMUSG00000030589 AllianceGenome:MGI:2386851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cell population proliferation; positive regulation of Ras protein signal transduction; and response to extracellular stimulus. Predicted to act upstream of or within cell differentiation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Is expressed in several structures, including genitourinary system; liver; peritoneal cavity; spleen; and tongue. Orthologous to human RASGRP4 (RAS guanyl releasing protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 8.9), duodenum adult (RPKM 8.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    7 16.94 cM; 7 B1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28834358..28853386)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29134607..29153961)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ryanodine receptor 1, skeletal muscle Neighboring gene predicted gene, 26604 Neighboring gene STARR-seq mESC enhancer starr_18458 Neighboring gene microRNA 1963 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29926525-29926755 Neighboring gene STARR-positive B cell enhancer ABC_E9287 Neighboring gene family with sequence similarity 98, member C Neighboring gene STARR-positive B cell enhancer ABC_E8159 Neighboring gene sprouty-related EVH1 domain containing 3 Neighboring gene gametogenetin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (7)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to extracellular stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RAS guanyl-releasing protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001174155.1NP_001167626.1  RAS guanyl-releasing protein 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC164564, AK049562, BY749980
      Consensus CDS
      CCDS85258.1
      UniProtKB/TrEMBL
      E9QKB7
      Related
      ENSMUSP00000125137.2, ENSMUST00000159975.8
      Conserved Domains (4) summary
      smart00147
      Location:197432
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:541595
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13499
      Location:465494
      EF-hand_7; EF-hand domain pair
      cl02520
      Location:82164
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    2. NM_145149.4NP_660131.2  RAS guanyl-releasing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_660131.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC164564, AK049562, BY749980
      Consensus CDS
      CCDS85257.1
      UniProtKB/Swiss-Prot
      Q3TNQ1, Q3TRL5, Q3U3I4, Q811P7, Q8BKV7, Q8BTM9, Q91ZC8, Q920A2
      UniProtKB/TrEMBL
      E9QKB7
      Related
      ENSMUSP00000032811.6, ENSMUST00000032811.12
      Conserved Domains (4) summary
      smart00147
      Location:197432
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:541590
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13499
      Location:465494
      EF-hand_7; EF-hand domain pair
      cl02520
      Location:82164
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

    RNA

    1. NR_045676.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate splice sites in the coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC164564

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28834358..28853386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250525.2XP_011248827.1  RAS guanyl-releasing protein 4 isoform X2

      UniProtKB/TrEMBL
      E9QKB7
      Related
      ENSMUSP00000124183.2, ENSMUST00000159351.3
      Conserved Domains (3) summary
      smart00147
      Location:197432
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:541595
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl02520
      Location:82164
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    2. XM_017322159.3XP_017177648.1  RAS guanyl-releasing protein 4 isoform X1

      UniProtKB/TrEMBL
      E9QKB7
      Conserved Domains (3) summary
      smart00147
      Location:201436
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:545599
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl02520
      Location:86168
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    3. XM_017322161.3XP_017177650.1  RAS guanyl-releasing protein 4 isoform X4

      UniProtKB/TrEMBL
      E9QKB7
      Conserved Domains (3) summary
      smart00147
      Location:201436
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:545599
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl02520
      Location:86168
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    4. XM_017322160.3XP_017177649.1  RAS guanyl-releasing protein 4 isoform X3

      UniProtKB/TrEMBL
      E9QKB7
      Conserved Domains (3) summary
      smart00147
      Location:201436
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:545594
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl02520
      Location:86168
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    5. XM_017322162.3XP_017177651.1  RAS guanyl-releasing protein 4 isoform X5

      UniProtKB/TrEMBL
      E9QKB7
      Conserved Domains (3) summary
      smart00147
      Location:201436
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:545594
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl02520
      Location:86168
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    6. XM_017322163.3XP_017177652.1  RAS guanyl-releasing protein 4 isoform X6

      UniProtKB/TrEMBL
      E9QKB7
      Conserved Domains (3) summary
      smart00147
      Location:155390
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:499553
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl02520
      Location:40122
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    7. XM_017322164.3XP_017177653.1  RAS guanyl-releasing protein 4 isoform X7

      UniProtKB/TrEMBL
      E9QKB7
      Conserved Domains (3) summary
      smart00147
      Location:201436
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cl00040
      Location:545582
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl02520
      Location:86168
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    8. XM_017322165.3XP_017177654.1  RAS guanyl-releasing protein 4 isoform X8

      UniProtKB/TrEMBL
      E9QKB7
      Conserved Domains (3) summary
      smart00147
      Location:201436
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:545577
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl02520
      Location:86168
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

    RNA

    1. XR_001785525.3 RNA Sequence

    2. XR_001785526.3 RNA Sequence

    3. XR_001785524.3 RNA Sequence

    4. XR_001785523.3 RNA Sequence