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    B3gnt8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 [ Mus musculus (house mouse) ]

    Gene ID: 232984, updated on 5-Mar-2024

    Summary

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    Official Symbol
    B3gnt8provided by MGI
    Official Full Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8provided by MGI
    Primary source
    MGI:MGI:2385269
    See related
    Ensembl:ENSMUSG00000059479 AllianceGenome:MGI:2385269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B3galt7; B7galt7
    Summary
    Predicted to enable protein N-acetylglucosaminyltransferase activity. Predicted to be involved in poly-N-acetyllactosamine biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Is expressed in alimentary system; integumental system; nervous system; and nucleus pulposus. Orthologous to human B3GNT8 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 26.8), ovary adult (RPKM 11.3) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A3; 7 13.94 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25327025..25328917)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25627600..25629492)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glutamate rich 4 Neighboring gene STARR-positive B cell enhancer ABC_E9286 Neighboring gene predicted gene, 38969 Neighboring gene distal membrane arm assembly complex 2 Neighboring gene predicted gene, 57782 Neighboring gene branched chain ketoacid dehydrogenase E1, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E8156 Neighboring gene STARR-positive B cell enhancer ABC_E10430 Neighboring gene STARR-seq mESC enhancer starr_18309 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26443819-26444002 Neighboring gene STARR-positive B cell enhancer ABC_E696 Neighboring gene exosome component 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells. Seko A, et al. J Biol Chem, 2008 Nov 28. PMID 18826941, Free PMC Article
    2. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. up-regulation of beta3Gn-T8 in differentiated cells increases poly-N-acetyllactosamine chains by activating intrinsic beta3Gn-T2.
      Title: Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC32391

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in poly-N-acetyllactosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly-N-acetyllactosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
    Names
    BGnT-8
    UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 7
    beta-1,3-Gn-T8
    beta-1,3-N-acetylglucosaminyltransferase 8
    beta3Gn-T8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001036740.2 → NP_001031817.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

      See identical proteins and their annotated locations for NP_001031817.1

      Status: VALIDATED

      Source sequence(s)
      AK042388, BY206280, BY320287, BY554292
      Consensus CDS
      CCDS20989.1
      UniProtKB/Swiss-Prot
      Q8R3I9
      Related
      ENSMUSP00000092277.5, ENSMUST00000076034.8
      Conserved Domains (1) summary
      cl21608
      Location:154 → 341
      Galactosyl_T; Galactosyltransferase

    2. NM_146184.4 → NP_666296.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

      See identical proteins and their annotated locations for NP_666296.1

      Status: VALIDATED

      Source sequence(s)
      AK042388, BY206280, BY554292
      Consensus CDS
      CCDS20989.1
      UniProtKB/Swiss-Prot
      Q8R3I9
      Related
      ENSMUST00000206824.2
      Conserved Domains (1) summary
      cl21608
      Location:154 → 341
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      25327025..25328917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539853.4 → XP_006539916.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 isoform X1

      See identical proteins and their annotated locations for XP_006539916.1

      UniProtKB/Swiss-Prot
      Q8R3I9
      Conserved Domains (1) summary
      cl21608
      Location:154 → 341
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3I9.1 GenPept UniProtKB/Swiss-Prot:Q8R3I9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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