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    Mypop Myb-related transcription factor, partner of profilin [ Mus musculus (house mouse) ]

    Gene ID: 232934, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mypopprovided by MGI
    Official Full Name
    Myb-related transcription factor, partner of profilinprovided by MGI
    Primary source
    MGI:MGI:2446472
    See related
    Ensembl:ENSMUSG00000048481 AllianceGenome:MGI:2446472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P42pop; Myodysa
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and spleen. Orthologous to human MYPOP (Myb related transcription factor, partner of profilin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 11.9), testis adult (RPKM 10.6) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A3; 7 9.45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18725230..18735691)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18991240..19001766)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene NOVA alternative splicing regulator 2 Neighboring gene predicted gene, 38952 Neighboring gene STARR-positive B cell enhancer ABC_E1080 Neighboring gene nanos C2HC-type zinc finger 2 Neighboring gene interferon regulatory factor 2 binding protein 1 Neighboring gene forkhead box A3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Physical and genetic characterization of the distal segment of the myotonic dystrophy area on 19q. Jansen G, et al. Genomics, 1992 Jul. PMID 1639379
    2. Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes. Krappa R, et al. Proc Natl Acad Sci U S A, 1999 Apr 13. PMID 10200314, Free PMC Article
    3. Profilin regulates the activity of p42POP, a novel Myb-related transcription factor. Lederer M, et al. J Cell Sci, 2005 Jan 15. PMID 15615774
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myb-related transcription factor, partner of profilin
    Names
    Myb protein P42POP
    myb-related protein p42POP
    myotonic dystrophy region
    partner of profilin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420727.1 → NP_001407656.1  myb-related transcription factor, partner of profilin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC170864
      UniProtKB/Swiss-Prot
      Q7TNR1, Q8CFP0, Q8R4U1

    2. NM_001420728.1 → NP_001407657.1  myb-related transcription factor, partner of profilin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC170864

    3. NM_001420729.1 → NP_001407658.1  myb-related transcription factor, partner of profilin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC170864

    4. NM_145579.4 → NP_663554.1  myb-related transcription factor, partner of profilin isoform 1

      See identical proteins and their annotated locations for NP_663554.1

      Status: VALIDATED

      Source sequence(s)
      AC170864
      Consensus CDS
      CCDS39792.1
      UniProtKB/Swiss-Prot
      Q7TNR1, Q8CFP0, Q8R4U1
      Related
      ENSMUSP00000058718.9, ENSMUST00000059331.9
      Conserved Domains (1) summary
      pfam13873
      Location:20 → 96
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      18725230..18735691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4U1.1 GenPept UniProtKB/Swiss-Prot:Q8R4U1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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