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    Zscan22 zinc finger and SCAN domain containing 22 [ Mus musculus (house mouse) ]

    Gene ID: 232878, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zscan22provided by MGI
    Official Full Name
    zinc finger and SCAN domain containing 22provided by MGI
    Primary source
    MGI:MGI:2443312
    See related
    Ensembl:ENSMUSG00000054715 AllianceGenome:MGI:2443312
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hkr2; D530006B18Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human ZSCAN22 (zinc finger and SCAN domain containing 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 7.4), ovary adult (RPKM 6.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A1; 7 7.68 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12631736..12643010)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (12897798..12909083)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45971 Neighboring gene STARR-positive B cell enhancer ABC_E6510 Neighboring gene zinc finger protein 128 Neighboring gene STARR-positive B cell enhancer mm9_chr7:13482923-13483223 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13495643-13495826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13507414-13507597 Neighboring gene ribosomal protein S5 Neighboring gene ring finger protein 225 Neighboring gene predicted gene, 26325

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 22
    Names
    GLI-Kruppel family member HKR2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001447.3 → NP_001001447.1  zinc finger and SCAN domain-containing protein 22 isoform a

      See identical proteins and their annotated locations for NP_001001447.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant (1). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AK052559, AK163694, BB849089
      Consensus CDS
      CCDS20816.1
      UniProtKB/TrEMBL
      Q8BGS5
      Related
      ENSMUSP00000057651.5, ENSMUST00000055528.11
      Conserved Domains (3) summary
      COG5048
      Location:181 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:328 → 348
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:45 → 129
      SCAN; SCAN domain

    2. NM_001290436.1 → NP_001277365.1  zinc finger and SCAN domain-containing protein 22 isoform a

      See identical proteins and their annotated locations for NP_001277365.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC107704, AK052559, AK163694, BB849089, BB871911
      Consensus CDS
      CCDS20816.1
      UniProtKB/TrEMBL
      Q8BGS5
      Conserved Domains (3) summary
      COG5048
      Location:181 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:328 → 348
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:45 → 129
      SCAN; SCAN domain

    3. NM_001290438.1 → NP_001277367.1  zinc finger and SCAN domain-containing protein 22 isoform a

      See identical proteins and their annotated locations for NP_001277367.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant (1). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AK078591, AK163694, BB849089
      Consensus CDS
      CCDS20816.1
      UniProtKB/TrEMBL
      Q8BGS5
      Related
      ENSMUSP00000113314.2, ENSMUST00000120809.2
      Conserved Domains (3) summary
      COG5048
      Location:181 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:328 → 348
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:45 → 129
      SCAN; SCAN domain

    4. NM_001290440.1 → NP_001277369.1  zinc finger and SCAN domain-containing protein 22 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of the first exon and lacks an alternate exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AK163694, BB849089
      UniProtKB/TrEMBL
      Q3TQC3
      Conserved Domains (3) summary
      COG5048
      Location:66 → 364
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:213 → 233
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:225 → 250
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001290441.1 → NP_001277370.1  zinc finger and SCAN domain-containing protein 22 isoform c

      See identical proteins and their annotated locations for NP_001277370.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction at the 3' end of the first exon and lacks an alternate exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (c).
      Source sequence(s)
      AK163694, BB849089, BY288068
      Consensus CDS
      CCDS71889.1
      UniProtKB/TrEMBL
      Q3TQC3
      Related
      ENSMUSP00000113486.2, ENSMUST00000119989.3
      Conserved Domains (2) summary
      COG5048
      Location:22 → 320
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:169 → 189
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001290442.1 → NP_001277371.1  zinc finger and SCAN domain-containing protein 22 isoform c

      See identical proteins and their annotated locations for NP_001277371.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (c).
      Source sequence(s)
      AC107704, AK163694, BB849089
      Consensus CDS
      CCDS71889.1
      UniProtKB/TrEMBL
      Q3TQC3
      Related
      ENSMUSP00000112684.2, ENSMUST00000117189.2
      Conserved Domains (2) summary
      COG5048
      Location:22 → 320
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:169 → 189
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      12631736..12643010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242427.2 → XP_030098287.1  zinc finger and SCAN domain-containing protein 22 isoform X1

      UniProtKB/TrEMBL
      Q3TQC3
      Conserved Domains (2) summary
      COG5048
      Location:22 → 320
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:169 → 189
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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