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    Zfp628 zinc finger protein 628 [ Mus musculus (house mouse) ]

    Gene ID: 232816, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp628provided by MGI
    Official Full Name
    zinc finger protein 628provided by MGI
    Primary source
    MGI:MGI:2665174
    See related
    Ensembl:ENSMUSG00000074406 AllianceGenome:MGI:2665174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zec; Znf628
    Summary
    Enables DNA binding activity and DNA-binding transcription factor activity. Involved in spermatogenesis. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in genitourinary system. Orthologous to human ZNF628 (zinc finger protein 628). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 18.7), ovary adult (RPKM 17.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp628 in Genome Data Viewer
    Location:
    7 A1; 7 2.84 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4918221..4925001)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4915181..4922003)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36210 Neighboring gene STARR-seq mESC enhancer starr_17947 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10424 Neighboring gene microRNA 12202 Neighboring gene N-acetyltransferase 14 Neighboring gene scavenger receptor cysteine rich family, 5 domains Neighboring gene STARR-positive B cell enhancer ABC_E6508

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZEC, a zinc finger protein with novel binding specificity and transcription regulatory activity. Chen GY, et al. Gene, 2004 Sep 29. PMID 15556296
    2. ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis. Gustafson EA, et al. Mol Cell Biol, 2020 Mar 16. PMID 31932482, Free PMC Article
    3. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data identify ZFP628 as a novel transcriptional regulator of stage-specific spermatogenesis.
      Title: ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 628
    Names
    zinc finger protein Zec
    zinc finger protein expressed in embryonal cells and certain adult organs

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420651.1 → NP_001407580.1  zinc finger protein 628 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157563
      UniProtKB/Swiss-Prot
      Q3U2L5, Q6P5B3, Q8CJ78

    2. NM_001420653.1 → NP_001407582.1  zinc finger protein 628 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157563
      UniProtKB/Swiss-Prot
      Q3U2L5, Q6P5B3, Q8CJ78

    3. NM_001420655.1 → NP_001407584.1  zinc finger protein 628 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157563

    4. NM_001420656.1 → NP_001407585.1  zinc finger protein 628 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157563

    5. NM_170759.3 → NP_739565.2  zinc finger protein 628 isoform 1

      See identical proteins and their annotated locations for NP_739565.2

      Status: VALIDATED

      Source sequence(s)
      AC157563
      Consensus CDS
      CCDS51979.1
      UniProtKB/Swiss-Prot
      Q3U2L5, Q6P5B3, Q8CJ78
      Related
      ENSMUSP00000112058.3, ENSMUST00000116354.4
      Conserved Domains (3) summary
      COG5048
      Location:41 → 221
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:148 → 168
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:351 → 368
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4918221..4925001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CJ78.2 GenPept UniProtKB/Swiss-Prot:Q8CJ78

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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