Kmt5c lysine methyltransferase 5C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kmt5cprovided by MGI
Official Full Name: lysine methyltransferase 5Cprovided by MGI
Primary source: MGI:MGI:2385262
See related: Ensembl:ENSMUSG00000059851 AllianceGenome:MGI:2385262
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Suv420h2; Suv4-20h2
Summary: Enables histone binding activity and histone methyltransferase activity (H4-K20 specific). Involved in positive regulation of isotype switching. Acts upstream of or within histone H4-K20 trimethylation. Located in condensed chromosome, centromeric region. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; sensory organ; and urinary system. Orthologous to human KMT5C (lysine methyltransferase 5C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 51.2), colon adult (RPKM 39.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.74 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (4743091..4750513)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (4740092..4747514)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells.
Title: H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells.
KMT5c modulates adipocyte thermogenesis by regulating Trp53 expression.
Title: KMT5c modulates adipocyte thermogenesis by regulating Trp53 expression.
expression of Suv4-20h2 leads to sustained levels of H4K20me3, developmental arrest, and defects in S-phase progression.
Title: SUV4-20 activity in the preimplantation mouse embryo controls timely replication.
Upregulation of long non-coding RNA PAPAS in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2.
Title: lncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress.
Results uncover a lncRNA-mediated mechanism that guides Suv4-20h2 to specific genomic loci to establish a more compact chromatin structure in growth-arrested cells.
Title: Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing.
Data suggest that Suv4-20h1/Suv4-20h2 activity is required for fidelity of chromosome distribution during meiosis in oocyte; Suv4-20h1/Suv4-20h2 appear to control histone 4 methylation, centromere structure, and oocyte maturation/oogenesis.
Title: Mouse oocyte meiosis is disturbed by knockdown of Suv4-20h.
Suv4-20h2 is involved in the initial loading or maintenance of cohesion subunits
Title: Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin.
Abrogation of Suv4-20h enzymes and loss of heterochromatic mark H4K20me3 at telomeric heterochromatin facilitates telomere reprogramming and provides an increased tumorigenic potential to induced pluripotent stem cells.
Title: Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells.
SUV420H1 and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation
Title: Comparative analyses of SUV420H1 isoforms and SUV420H2 reveal differences in their cellular localization and effects on myogenic differentiation.
There is a novel role for histone lysine methylation in controlling telomere recombination.
Title: Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables S-adenosyl-L-methionine binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone H4K20 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4K20 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K20 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K20 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K20me methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of isotype switching	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
part_of heterochromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of pericentric heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase KMT5C

Names: [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B; histone-lysine N-methyltransferase SUV420H2; lysine-specific methyltransferase 5C; su(var)4-20 homolog 2; suppressor of variegation 4-20 homolog 2

NP_001108490.1

EC 2.1.1.361

EC 2.1.1.362

NP_001344973.1

EC 2.1.1.361

EC 2.1.1.362

NP_001407571.1

EC 2.1.1.361

EC 2.1.1.362

NP_001407572.1

EC 2.1.1.361

EC 2.1.1.362

NP_001407573.1

EC 2.1.1.361

EC 2.1.1.362

NP_001407574.1

EC 2.1.1.361

EC 2.1.1.362

NP_001407575.1

EC 2.1.1.361

EC 2.1.1.362

NP_001407576.1

EC 2.1.1.361

EC 2.1.1.362

NP_001407577.1

EC 2.1.1.361

EC 2.1.1.362

NP_001407578.1

EC 2.1.1.361

EC 2.1.1.362

NP_666289.2

EC 2.1.1.361

EC 2.1.1.362

XP_006539834.1

EC 2.1.1.361

EC 2.1.1.362

XP_006539835.1

EC 2.1.1.361

EC 2.1.1.362

XP_036008833.1

EC 2.1.1.361

EC 2.1.1.362

XP_036008834.1

EC 2.1.1.361

EC 2.1.1.362

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001115018.2 → NP_001108490.1 histone-lysine N-methyltransferase KMT5C isoform 1

See identical proteins and their annotated locations for NP_001108490.1

Status: VALIDATED

Source sequence(s)

AC161197

Consensus CDS

CCDS20743.2

UniProtKB/Swiss-Prot

Q5RKP6, Q6Q783, Q8R1C5

Related

ENSMUSP00000096452.3, ENSMUST00000098853.9

Conserved Domains (2) summary

smart00317
Location:120 → 224

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cl25800
Location:245 → 366

GGN; Gametogenetin
NM_001358044.2 → NP_001344973.1 histone-lysine N-methyltransferase KMT5C isoform 1

Status: VALIDATED

Source sequence(s)

AC161197

Consensus CDS

CCDS20743.2

UniProtKB/Swiss-Prot

Q5RKP6, Q6Q783, Q8R1C5

Related

ENSMUSP00000104223.4, ENSMUST00000108582.10

Conserved Domains (2) summary

smart00317
Location:120 → 224

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cl25800
Location:245 → 366

GGN; Gametogenetin
NM_001420642.1 → NP_001407571.1 histone-lysine N-methyltransferase KMT5C isoform 2

Status: VALIDATED

Source sequence(s)

AC161197
NM_001420643.1 → NP_001407572.1 histone-lysine N-methyltransferase KMT5C isoform 3

Status: VALIDATED

Source sequence(s)

AC161197
NM_001420644.1 → NP_001407573.1 histone-lysine N-methyltransferase KMT5C isoform 4

Status: VALIDATED

Source sequence(s)

AC161197
NM_001420645.1 → NP_001407574.1 histone-lysine N-methyltransferase KMT5C isoform 5

Status: VALIDATED

Source sequence(s)

AC161197
NM_001420646.1 → NP_001407575.1 histone-lysine N-methyltransferase KMT5C isoform 6

Status: VALIDATED

Source sequence(s)

AC161197
NM_001420647.1 → NP_001407576.1 histone-lysine N-methyltransferase KMT5C isoform 7

Status: VALIDATED

Source sequence(s)

AC161197
NM_001420648.1 → NP_001407577.1 histone-lysine N-methyltransferase KMT5C isoform 7

Status: VALIDATED

Source sequence(s)

AC161197
NM_001420649.1 → NP_001407578.1 histone-lysine N-methyltransferase KMT5C isoform 8

Status: VALIDATED

Source sequence(s)

AC161197
NM_146177.3 → NP_666289.2 histone-lysine N-methyltransferase KMT5C isoform 1

See identical proteins and their annotated locations for NP_666289.2

Status: VALIDATED

Source sequence(s)

AC161197

Consensus CDS

CCDS20743.2

UniProtKB/Swiss-Prot

Q5RKP6, Q6Q783, Q8R1C5

Related

ENSMUSP00000104224.3, ENSMUST00000108583.9

Conserved Domains (2) summary

smart00317
Location:120 → 224

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cl25800
Location:245 → 366

GGN; Gametogenetin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

4743091..4750513

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539772.1 → XP_006539835.1 histone-lysine N-methyltransferase KMT5C isoform X1

See identical proteins and their annotated locations for XP_006539835.1

Conserved Domains (2) summary

PHA02682
Location:281 → 346

PHA02682; ORF080 virion core protein; Provisional

cl40432
Location:196 → 279

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
XM_036152941.1 → XP_036008834.1 histone-lysine N-methyltransferase KMT5C isoform X2

Conserved Domains (2) summary

PHA02682
Location:276 → 397

PHA02682; ORF080 virion core protein; Provisional

cd19185
Location:102 → 274

SET_KMT5C; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins
XM_006539771.5 → XP_006539834.1 histone-lysine N-methyltransferase KMT5C isoform X1

See identical proteins and their annotated locations for XP_006539834.1

Conserved Domains (2) summary

PHA02682
Location:281 → 346

PHA02682; ORF080 virion core protein; Provisional

cl40432
Location:196 → 279

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
XM_036152940.1 → XP_036008833.1 histone-lysine N-methyltransferase KMT5C isoform X2

Conserved Domains (2) summary

PHA02682
Location:276 → 397

PHA02682; ORF080 virion core protein; Provisional

cd19185
Location:102 → 274

SET_KMT5C; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins