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    Ccdc136 coiled-coil domain containing 136 [ Mus musculus (house mouse) ]

    Gene ID: 232664, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ccdc136provided by MGI
    Official Full Name
    coiled-coil domain containing 136provided by MGI
    Primary source
    MGI:MGI:1918128
    See related
    Ensembl:ENSMUSG00000029769 AllianceGenome:MGI:1918128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921511K06Rik
    Summary
    Involved in acrosome assembly and single fertilization. Located in acrosomal membrane. Is expressed in retina outer nuclear layer. Orthologous to human CCDC136 (coiled-coil domain containing 136). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 86.4), cerebellum adult (RPKM 10.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A3.3; 6 12.36 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29396296..29426954)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29396574..29426995)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene calumenin Neighboring gene opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) Neighboring gene nuclear encoded tRNA proline 6 (anticodon AGG) Neighboring gene blue cone (S) opsin upstream regulatory region Neighboring gene filamin C, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr6:29417613-29417914 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Novel Testis-Specific Gene, Ccdc136, Is Required for Acrosome Formation and Fertilization in Mice. Geng Q, et al. Reprod Sci, 2016 Oct. PMID 27076447
    2. Modeling of Photoreceptor Donor-Host Interaction Following Transplantation Reveals a Role for Crx, Müller Glia, and Rho/ROCK Signaling in Neurite Outgrowth. Tsai ELS, et al. Stem Cells, 2019 Apr. PMID 30715780
    3. InVision: An optimized tissue clearing approach for three-dimensional imaging and analysis of intact rodent eyes. Gurdita A, et al. iScience, 2021 Aug 20. PMID 34430805, Free PMC Article
    4. Biphasic expression of thyroid hormone receptor TRβ1 in mammalian retina and anterior ocular tissues. Ng L, et al. Front Endocrinol (Lausanne), 2023. PMID 37033230, Free PMC Article
    5. Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line. Smiley S, et al. Sci Rep, 2016 Mar 11. PMID 26965927, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2)  1 citation

    General gene information

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    Homology

    Clone Names

    • MGC8047

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in acrosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 136
    Names
    taraco

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201378.2 → NP_001188307.1  coiled-coil domain-containing protein 136 isoform 2

      See identical proteins and their annotated locations for NP_001188307.1

      Status: VALIDATED

      Source sequence(s)
      AC044807
      Consensus CDS
      CCDS59693.1
      UniProtKB/TrEMBL
      E6Y2W7
      Related
      ENSMUSP00000137747.2, ENSMUST00000180829.8
      Conserved Domains (2) summary
      pfam12018
      Location:61 → 206
      DUF3508; Domain of unknown function (DUF3508)
      cl23720
      Location:11 → 100
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_001347071.2 → NP_001334000.1  coiled-coil domain-containing protein 136 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC044807
      Consensus CDS
      CCDS85019.1
      UniProtKB/Swiss-Prot
      Q3TVA9, Q923E5
      UniProtKB/TrEMBL
      E9QP94
      Related
      ENSMUSP00000093789.6, ENSMUST00000096084.13

    3. NM_001347072.2 → NP_001334001.1  coiled-coil domain-containing protein 136 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC044807
      Consensus CDS
      CCDS85020.1
      UniProtKB/Swiss-Prot
      Q3TVA9, Q923E5
      UniProtKB/TrEMBL
      D3Z165
      Related
      ENSMUSP00000110930.2, ENSMUST00000115275.8

    4. NM_001347073.2 → NP_001334002.1  coiled-coil domain-containing protein 136 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC044807
      Consensus CDS
      CCDS85021.1
      UniProtKB/TrEMBL
      A0A0N4SW14
      Related
      ENSMUSP00000145331.2, ENSMUST00000145310.8
      Conserved Domains (1) summary
      COG1196
      Location:101 → 404
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. NM_001405562.1 → NP_001392491.1  coiled-coil domain-containing protein 136 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC044807

    6. NM_001405644.1 → NP_001392573.1  coiled-coil domain-containing protein 136 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC044807

    7. NM_001405645.1 → NP_001392574.1  coiled-coil domain-containing protein 136 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC044807

    8. NM_001405646.1 → NP_001392575.1  coiled-coil domain-containing protein 136 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC044807

    9. NM_001405647.1 → NP_001392576.1  coiled-coil domain-containing protein 136 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC044807

    10. NM_001405648.1 → NP_001392577.1  coiled-coil domain-containing protein 136 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC044807

    11. NM_001405649.1 → NP_001392578.1  coiled-coil domain-containing protein 136 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC044807

    12. NM_001405650.1 → NP_001392579.1  coiled-coil domain-containing protein 136 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC044807

    13. NM_001405651.1 → NP_001392580.1  coiled-coil domain-containing protein 136 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC044807

    14. NM_001405652.1 → NP_001392581.1  coiled-coil domain-containing protein 136 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC044807

    15. NM_001405653.1 → NP_001392582.1  coiled-coil domain-containing protein 136 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC044807

    16. NM_001405654.1 → NP_001392583.1  coiled-coil domain-containing protein 136 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC044807

    17. NM_001405655.1 → NP_001392584.1  coiled-coil domain-containing protein 136 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC044807

    18. NM_001405656.1 → NP_001392585.1  coiled-coil domain-containing protein 136 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC044807

    19. NM_001405657.1 → NP_001392586.1  coiled-coil domain-containing protein 136 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC044807

    20. NM_001405658.1 → NP_001392587.1  coiled-coil domain-containing protein 136 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC044807
      UniProtKB/TrEMBL
      A0A0N4SW14

    21. NM_001405659.1 → NP_001392588.1  coiled-coil domain-containing protein 136 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC044807

    22. NM_001405660.1 → NP_001392589.1  coiled-coil domain-containing protein 136 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC044807

    23. NM_145574.4 → NP_663549.3  coiled-coil domain-containing protein 136 isoform 1

      See identical proteins and their annotated locations for NP_663549.3

      Status: VALIDATED

      Source sequence(s)
      AC044807
      Consensus CDS
      CCDS51736.2
      UniProtKB/Swiss-Prot
      Q3TVA9, Q923E5
      UniProtKB/TrEMBL
      E6Y2W6
      Related
      ENSMUSP00000137673.2, ENSMUST00000181464.8
      Conserved Domains (2) summary
      pfam12018
      Location:61 → 206
      DUF3508; Domain of unknown function (DUF3508)
      cl23720
      Location:11 → 100
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      29396296..29426954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166095.1 → XP_036021988.1  coiled-coil domain-containing protein 136 isoform X11

      Conserved Domains (2) summary
      COG1196
      Location:344 → 614
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:106 → 449
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_006505056.5 → XP_006505119.1  coiled-coil domain-containing protein 136 isoform X13

      Conserved Domains (1) summary
      TIGR02168
      Location:106 → 449
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_006505047.5 → XP_006505110.1  coiled-coil domain-containing protein 136 isoform X1

      UniProtKB/Swiss-Prot
      Q3TVA9, Q923E5
      Conserved Domains (2) summary
      COG1196
      Location:101 → 404
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:347 → 970
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_036166094.1 → XP_036021987.1  coiled-coil domain-containing protein 136 isoform X4

      UniProtKB/Swiss-Prot
      Q3TVA9, Q923E5
      Conserved Domains (1) summary
      COG1196
      Location:101 → 404
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_006505055.5 → XP_006505118.1  coiled-coil domain-containing protein 136 isoform X12

      Conserved Domains (2) summary
      COG1196
      Location:344 → 614
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:106 → 449
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_036166096.1 → XP_036021989.1  coiled-coil domain-containing protein 136 isoform X15

      Conserved Domains (1) summary
      COG1196
      Location:101 → 404
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_006505052.4 → XP_006505115.1  coiled-coil domain-containing protein 136 isoform X6

      See identical proteins and their annotated locations for XP_006505115.1

      UniProtKB/Swiss-Prot
      Q3TVA9, Q923E5
      Conserved Domains (2) summary
      COG0419
      Location:153 → 793
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02168
      Location:106 → 449
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_006505053.4 → XP_006505116.1  coiled-coil domain-containing protein 136 isoform X7

      UniProtKB/Swiss-Prot
      Q3TVA9, Q923E5
      Conserved Domains (2) summary
      COG0419
      Location:153 → 793
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02168
      Location:106 → 449
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_006505048.4 → XP_006505111.1  coiled-coil domain-containing protein 136 isoform X3

      UniProtKB/Swiss-Prot
      Q3TVA9, Q923E5
      Conserved Domains (2) summary
      COG0419
      Location:153 → 793
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02168
      Location:106 → 449
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    10. XM_006505049.4 → XP_006505112.1  coiled-coil domain-containing protein 136 isoform X5

      UniProtKB/Swiss-Prot
      Q3TVA9, Q923E5
      UniProtKB/TrEMBL
      F6VCV9
      Related
      ENSMUSP00000118132.3, ENSMUST00000154619.5
      Conserved Domains (2) summary
      COG0419
      Location:8 → 635
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:3 → 317
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_001785125.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TVA9.2 GenPept UniProtKB/Swiss-Prot:Q3TVA9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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