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    Caprin2 caprin family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 232560, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Caprin2provided by MGI
    Official Full Name
    caprin family member 2provided by MGI
    Primary source
    MGI:MGI:2448541
    See related
    Ensembl:ENSMUSG00000030309 AllianceGenome:MGI:2448541
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adir; Eeg1; C1qdc1; rng140
    Summary
    This gene encodes a member of the caprin family. The encoded protein may function as an RNA-binding protein that induces the formation of RNA granules and plays an important role in brain function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.2), limb E14.5 (RPKM 2.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Caprin2 in Genome Data Viewer
    Location:
    6 G3; 6 78.62 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (148743990..148797756, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (148842492..148896257, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene importin 8 Neighboring gene RIKEN cDNA 2610017A05 gene Neighboring gene STARR-positive B cell enhancer ABC_E1717 Neighboring gene predicted gene, 36762 Neighboring gene STARR-seq mESC enhancer starr_17840 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene SIN3-HDAC complex associated factor Neighboring gene RIKEN cDNA 3010003L21 gene Neighboring gene STARR-seq mESC enhancer starr_17845 Neighboring gene STARR-positive B cell enhancer ABC_E4884

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation. Nakazawa K, et al. J Biol Chem, 2020 Oct 30. PMID 32839273, Free PMC Article
    2. FGF signals induce Caprin2 expression in the vertebrate lens. Lorén CE, et al. Differentiation, 2009 Apr. PMID 19275872
    3. Deficiency of the RNA binding protein caprin2 causes lens defects and features of Peters anomaly. Dash S, et al. Dev Dyn, 2015 Oct. PMID 26177727, Free PMC Article
    4. RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain. Shiina N, et al. J Biol Chem, 2010 Jul 30. PMID 20516077, Free PMC Article
    5. Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Takasato M, et al. Mech Dev, 2004 Jun. PMID 15172686

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation.
      Title: Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation.
    2. functions in distinct morphological events in mammalian eye development
      Title: Deficiency of the RNA binding protein caprin2 causes lens defects and features of Peters anomaly.
    3. RNG140 has roles in the maintenance of the dendritic structure in the adult vertebrate brain through localizing to a kind of RNA granules that are distinct from RNG105-containing granules
      Title: RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain.
    4. The authors have isolated and characterized mouse cytoplasmic activation/proliferation-associated protein-2 (Caprin2), with domains belonging to both the Caprin family and the C1q and tumour necrosis factor (TNF) super-family
      Title: FGF signals induce Caprin2 expression in the vertebrate lens.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA1873

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    caprin-2
    Names
    C1q domain containing 1
    C1q domain-containing protein 1
    RNA granule protein 140
    adiponectin r
    cytoplasmic activation/proliferation-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301351.2 → NP_001288280.1  caprin-2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC134542
      UniProtKB/Swiss-Prot
      Q05A80
      Conserved Domains (3) summary
      COG2604
      Location:47 → 177
      COG2604; Uncharacterized conserved protein [Function unknown]
      pfam00386
      Location:683 → 808
      C1q; C1q domain
      pfam12287
      Location:317 → 614
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

    2. NM_001411635.1 → NP_001398564.1  caprin-2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC134542
      UniProtKB/Swiss-Prot
      Q05A80, Q58E31, Q6ZPG7
      UniProtKB/TrEMBL
      E4NKG5

    3. NM_001411636.1 → NP_001398565.1  caprin-2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC134542

    4. NM_001411637.1 → NP_001398566.1  caprin-2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC134542
      Related
      ENSMUSP00000072165.6, ENSMUST00000072324.12

    5. NM_001411638.1 → NP_001398567.1  caprin-2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC134542

    6. NM_001411639.1 → NP_001398568.1  caprin-2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC134542
      Related
      ENSMUST00000204942.2

    7. NM_001411640.1 → NP_001398569.1  caprin-2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC134542

    8. NM_181541.5 → NP_853519.2  caprin-2 isoform 1

      See identical proteins and their annotated locations for NP_853519.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AC134542
      Consensus CDS
      CCDS39720.1
      UniProtKB/Swiss-Prot
      Q05A80, Q58E31, Q6ZPG7
      UniProtKB/TrEMBL
      E4NKG5
      Related
      ENSMUSP00000107195.3, ENSMUST00000111569.9
      Conserved Domains (5) summary
      COG5022
      Location:110 → 377
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:903 → 1028
      C1q; C1q domain
      pfam12287
      Location:528 → 839
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam13870
      Location:45 → 172
      DUF4201; Domain of unknown function (DUF4201)
      pfam18293
      Location:119 → 234
      Caprin-1_dimer; Caprin-1 dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      148743990..148797756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507041.5 → XP_006507104.1  caprin-2 isoform X3

      Conserved Domains (5) summary
      COG5022
      Location:110 → 367
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:893 → 1018
      C1q; C1q domain
      pfam12287
      Location:518 → 829
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam13870
      Location:45 → 172
      DUF4201; Domain of unknown function (DUF4201)
      pfam18293
      Location:119 → 224
      Caprin-1_dimer; Caprin-1 dimerization domain

    2. XM_036166093.1 → XP_036021986.1  caprin-2 isoform X6

      Conserved Domains (3) summary
      pfam00386
      Location:562 → 687
      C1q; C1q domain
      pfam12287
      Location:187 → 498
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:2 → 112
      Caprin-1_dimer; Caprin-1 dimerization domain

    3. XM_006507039.5 → XP_006507102.1  caprin-2 isoform X1

      See identical proteins and their annotated locations for XP_006507102.1

      UniProtKB/Swiss-Prot
      Q05A80, Q58E31, Q6ZPG7
      UniProtKB/TrEMBL
      E4NKG5
      Conserved Domains (5) summary
      COG5022
      Location:110 → 377
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:903 → 1028
      C1q; C1q domain
      pfam12287
      Location:528 → 839
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam13870
      Location:45 → 172
      DUF4201; Domain of unknown function (DUF4201)
      pfam18293
      Location:119 → 234
      Caprin-1_dimer; Caprin-1 dimerization domain

    4. XM_030255361.2 → XP_030111221.1  caprin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q05A80, Q58E31, Q6ZPG7
      UniProtKB/TrEMBL
      E4NKG5
      Conserved Domains (5) summary
      COG5022
      Location:110 → 377
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:903 → 1028
      C1q; C1q domain
      pfam12287
      Location:528 → 839
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam13870
      Location:45 → 172
      DUF4201; Domain of unknown function (DUF4201)
      pfam18293
      Location:119 → 234
      Caprin-1_dimer; Caprin-1 dimerization domain

    5. XM_006507040.5 → XP_006507103.1  caprin-2 isoform X2

      Conserved Domains (5) summary
      COG5022
      Location:110 → 377
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:902 → 1027
      C1q; C1q domain
      pfam12287
      Location:528 → 839
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam13870
      Location:45 → 172
      DUF4201; Domain of unknown function (DUF4201)
      pfam18293
      Location:119 → 234
      Caprin-1_dimer; Caprin-1 dimerization domain

    6. XM_036166092.1 → XP_036021985.1  caprin-2 isoform X4

      Conserved Domains (4) summary
      COG5022
      Location:3 → 255
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:781 → 906
      C1q; C1q domain
      pfam12287
      Location:406 → 717
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:2 → 112
      Caprin-1_dimer; Caprin-1 dimerization domain

    7. XM_030255362.2 → XP_030111222.1  caprin-2 isoform X4

      Conserved Domains (4) summary
      COG5022
      Location:3 → 255
      COG5022; Myosin heavy chain [General function prediction only]
      pfam00386
      Location:781 → 906
      C1q; C1q domain
      pfam12287
      Location:406 → 717
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:2 → 112
      Caprin-1_dimer; Caprin-1 dimerization domain

    RNA

    1. XR_004942949.1 RNA Sequence

    2. XR_004942948.1 RNA Sequence

    3. XR_004942950.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05A80.1 GenPept UniProtKB/Swiss-Prot:Q05A80

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